Risk factors for recurrent hypoglycemia in hospitalized diabetic patients admitted for severe hypoglycemia

Yonsei Medical Journal

Volumn 51, Issue 3, 2010, Pages 367-374

  Lin, Yen Yue ^a   Hsu, Chin Wang ^a   Sheu, Wayne Huey Herng ^b   Chu, Shi Jye ^a   Wu, Chin Pyng ^a   Tsai, Shih Hung ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Calcium channel blockers; Chronic kidney disease; Coronary artery disease; Diabetic complications; Hypoglycemia; Mellitus; Type 2 diabetes

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTILIPEMIC AGENT; BENZODIAZEPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GLITAZONE DERIVATIVE; INSULIN; MEGLITINIDE; METFORMIN; SULFONYLUREA;

AGED; CORONARY ARTERY DISEASE; DIABETIC PATIENT; DISEASE SEVERITY; FEMALE; GLOMERULUS FILTRATION RATE; HIGH RISK PATIENT; HUMAN; HYPOGLYCEMIA; INFECTION; KIDNEY DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NON INSULIN DEPENDENT DIABETES MELLITUS; RECURRENT DISEASE; REVIEW; RISK FACTOR; TEACHING HOSPITAL; TERTIARY HEALTH CARE;

AGED; AGED, 80 AND OVER; CALCIUM CHANNEL BLOCKERS; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; FEMALE; GLOMERULAR FILTRATION RATE; HOSPITALIZATION; HUMANS; HYPOGLYCEMIA; KIDNEY DISEASES; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; RECURRENCE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 77954248624     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2010.51.3.367     Document Type: Review

References (36)

1. Guettier JM, Gorden P. Hypoglycemia. Endocrinol Metab Clin North Am 2006;35:753-66, viii-ix.
2. Ben-Ami H, Nagachandran P, Mendelson A, Edoute Y. Druginduced hypoglycemic coma in 102 diabetic patients. Arch Intern Med 1999;159:281-4.
3. Kearney T, Dang C. Diabetic and endocrine emergencies. Postgrad Med J 2007;83:79-86.
4. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993;329:977-86.
5. Miller CD, Phillips LS, Ziemer DC, Gallina DL, Cook CB, Elkebbi IM. Hypoglycemia in patients with type 2 diabetes mellitus. Arch Intern Med 2001;161:1653-9.
6. Socransky SJ, Pirrallo RG, Rubin JM. Out-of-hospital treatment of hypoglycemia: refusal of transport and patient outcome. Acad Emerg Med 1998;5:1080-5.
7. Lobmann R, Smid HG, Pottag G, Wagner K, Heinze HJ, Lehnert H. Impairment and recovery of elementary cognitive function induced by hypoglycemia in type-1 diabetic patients and healthy controls. J Clin Endocrinol Metab 2000;85:2758-66.
8. Cryer P. Hypoglycemia: Pathophysiology, Diagnosis, and Treatment. New York: Oxford University Press; 1997.
9. Shorr RI, Ray WA, Daugherty JR, Griffin MR. Incidence and risk factors for serious hypoglycemia in older persons using insulin or sulfonylureas. Arch Intern Med 1997;157:1681-6.
10. Clustering of long-term complications in families with diabetes in the diabetes control and complications trial. The Diabetes Control and Complications Trial Research Group. Diabetes 1997;46: 1829-39.
11. Kuzuya T, Nakagawa S, Satoh J, Kanazawa Y, Iwamoto Y, Kobayashi M, et al. Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. Diabetes Res Clin Pract 2002;55:65-85.
12. Workgroup on Hypoglycemia, American Diabetes Association. Defining and reporting hypoglycemia in diabetes: a report from the American Diabetes Association Workgroup on Hypoglycemia. Diabetes Care 2005;28:1245-9.
13. Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function--measured and estimated glomerular filtration rate. N Engl J Med 2006;354:2473-83.
14. Mechem CC, Kreshak AA, Barger J, Shofer FS. The short-term outcome of hypoglycemic diabetic patients who refuse ambulance transport after out-of-hospital therapy. Acad Emerg Med 1998; 5:768-72.
15. Carter AJ, Keane PS, Dreyer JF. Transport refusal by hypoglycemic patients after on-scene intravenous dextrose. Acad Emerg Med 2002;9:855-7.
16. Block MB, Rubenstein AH. Spontaneous hypoglycemia in diabetic patients with renal insufficiency. JAMA 1970;213:1863-6.
17. Rutsky EA, McDaniel HG, Tharpe DL, Alred G, Pek S. Spontaneous hypoglycemia in chronic renal failure. Arch Intern Med 1978;138:1364-8.
18. Kreisberg RA. Diabetic dyslipidemia. Am J Cardiol 1998;82: 67U-73.
19. McGuinness OP. Defective glucose homeostasis during infection. Annu Rev Nutr 2005;25:9-35.
20. Fong YM, Marano MA, Moldawer LL, Wei H, Calvano SE, Kenney JS, et al. The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. J Clin Invest 1990; 85:1896-904.
21. Bell DS. Inflammation, insulin resistance, infection, diabetes, and atherosclerosis. Endocr Pract 2000;6:272-6.
22. Saeed M, Carlson GL, Little RA, Irving MH. Selective impairment of glucose storage in human sepsis. Br J Surg 1999;86:813-21.
23. Tsukuda K, Mogi M, Li JM, Iwanami J, Min LJ, Sakata A, et al. Diabetes-associated cognitive impairment is improved by a calcium channel blocker, nifedipine. Hypertension 2008;51:528-33.
24. Müller D, Zimmering M, Roehr CC. Should nifedipine be used to counter low blood sugar levels in children with persistent hyperinsulinaemic hypoglycaemia? Arch Dis Child 2004;89:83-5.
25. Fuhrman MP, Charney P, Mueller CM. Hepatic proteins and nutrition assessment. J Am Diet Assoc 2004;104:1258-64.
26. Weinsier RL, Hunker EM, Krumdieck CL, Butterworth CE, Jr. Hospital malnutrition. A prospective evaluation of general medical patients during the course of hospitalization. Am J Clin Nutr 1979;32:418-26.
27. Giordano R, Grottoli S, Brossa P, Pellegrino M, Destefanis S, Lanfranco F, et al. Alprazolam (a benzodiazepine activating GABA receptor) reduces the neuroendocrine responses to insulin-induced hypoglycaemia in humans. Clin Endocrinol (Oxf) 2003;59:314-20.
28. Stratton JR, Halter JB. Effect of a benzodiazepine (alprazolam) on plasma epinephrine and norepinephrine levels during exercise stress. Am J Cardiol 1985;56:136-9.
29. Morris AD, Boyle DI, McMahon AD, Pearce H, Erans JM, Newton RW, et al. ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes. DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside, Scotland. Medicines Monitoring Unit. Diabetes Care 1997;20: 1363-7.
30. Weidmann P, Boehlen LM, de Courten M, Ferrari P. Antihypertensive therapy in diabetic patients. J Hum Hypertens 1992;6 Suppl 2:S23-36.
31. Chelliah A, Burge MR. Hypoglycaemia in elderly patients with diabetes mellitus: causes and strategies for prevention. Drugs Aging 2004;21:511-30.
32. Kotler MN, Berman L, Rubenstein AH. Hypoglycaemia precipitated by propranolol. Lancet 1966;2:1389-90.
33. Barnett AH, Leslie D, Watkins PJ. Can insulin-treated diabetics be given beta-adrenergic blocking drugs? Br Med J 1980;280: 976-8.
34. Pandit MK, Burke J, Gustafson AB, Minocha A, Peivis AN. Drug-induced disorders of glucose tolerance. Ann Intern Med 1993;118:529-39.
35. Swislocki AL, Hoffman BB, Reaven GM. Insulin resistance, glucose intolerance and hyperinsulinemia in patients with hypertension. Am J Hypertens 1989;2(6 Pt 1):419-23.
36. Murphy MB, Lewis PJ, Kohner E, Schumer B, Dollery CT. Glucose intolerance in hypertensive patients treated with diuretics; a fourteen-year follow-up. Lancet 1982;2:1293-5.