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Volumn 23, Issue 7, 2010, Pages 1029-1039

Molecular profiling of invasive breast cancer by multiplex ligation-dependent probe amplification-based copy number analysis of tumor suppressor and oncogenes

Author keywords

amplification; breast cancer; copy number; MLPA; oncogenes

Indexed keywords

ADAM PROTEIN; ADAM9 PROTEIN; AURORA A KINASE; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; BINDING PROTEIN; CARBOXYPEPTIDASE; CELL CYCLE PROTEIN 6; CYCLIN D1; CYCLIN E1; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE (ATP HYDROLYSING) A; DNA TOPOISOMERASE (ATP HYDROLYSING) ALPHA; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR ALPHA; FIBROBLAST GROWTH FACTOR RECEPTOR 1; I KAPPA B KINASE BETA; INDUCIBLE NITRIC OXIDE SYNTHASE; MYC PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EMSY; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 4; UNCLASSIFIED DRUG; UVOMORULIN; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

EID: 77954242252     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2010.84     Document Type: Article
Times cited : (86)

References (63)
  • 1
    • 3042622482 scopus 로고    scopus 로고
    • HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues
    • Owens MA, Horten BC, Da Silva MM. HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues. Clin Breast Cancer 2004;5:63-69.
    • (2004) Clin Breast Cancer , vol.5 , pp. 63-69
    • Owens, M.A.1    Horten, B.C.2    Da Silva, M.M.3
  • 2
    • 2542638621 scopus 로고    scopus 로고
    • Targeted therapy in breast cancer: The HER-2/neu gene and protein
    • Ross JS, Fletcher JA, Bloom KJ, et al. Targeted therapy in breast cancer: the HER-2/neu gene and protein. Mol Cell Proteomics 2004;3:379-398.
    • (2004) Mol Cell Proteomics , vol.3 , pp. 379-398
    • Ross, J.S.1    Fletcher, J.A.2    Bloom, K.J.3
  • 3
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-712.
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1    Godolphin, W.2    Jones, L.A.3
  • 4
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-792.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 5
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab, mechanism of action and use in clinical practice
    • Hudis CA. Trastuzumab, mechanism of action and use in clinical practice. N Engl J Med 2007;357:39-51.
    • (2007) N Engl J Med , vol.357 , pp. 39-51
    • Hudis, C.A.1
  • 6
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 7
    • 0344333420 scopus 로고    scopus 로고
    • Prognostic and predictive value of c-erbB-2 overexpression in primary breast cancer, alone and in combination with other prognostic markers
    • Sjogren S, Inganas M, Lindgren A, et al. Prognostic and predictive value of c-erbB-2 overexpression in primary breast cancer, alone and in combination with other prognostic markers. J Clin Oncol 1998;16: 462-469.
    • (1998) J Clin Oncol , vol.16 , pp. 462-469
    • Sjogren, S.1    Inganas, M.2    Lindgren, A.3
  • 8
    • 0028360192 scopus 로고
    • ERBB2 amplification is associated with tamoxifen resistance in steroid-receptor positive breast cancer
    • Borg A, Baldetorp B, Ferno M, et al. ERBB2 amplification is associated with tamoxifen resistance in steroid-receptor positive breast cancer. Cancer Lett 1994; 81:137-144.
    • (1994) Cancer Lett , vol.81 , pp. 137-144
    • Borg, A.1    Baldetorp, B.2    Ferno, M.3
  • 9
    • 0029662337 scopus 로고    scopus 로고
    • C-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases
    • Carlomagno C, Perrone F, Gallo C, et al. c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases. J Clin Oncol 1996;14: 2702-2708.
    • (1996) J Clin Oncol , vol.14 , pp. 2702-2708
    • Carlomagno, C.1    Perrone, F.2    Gallo, C.3
  • 10
    • 0344333419 scopus 로고    scopus 로고
    • P53 and c-erbB-2 as markers of resistance to adjuvant chemotherapy in breast cancer
    • Tetu B, Brisson J, Plante V, et al. p53 and c-erbB-2 as markers of resistance to adjuvant chemotherapy in breast cancer. Mod Pathol 1998;11:823-830.
    • (1998) Mod Pathol , vol.11 , pp. 823-830
    • Tetu, B.1    Brisson, J.2    Plante, V.3
  • 11
    • 33744969590 scopus 로고    scopus 로고
    • Topoisomerase IIalpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401
    • Tanner M, Isola J, Wiklund T, et al. Topoisomerase IIalpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401. J Clin Oncol 2006;24:2428-2436.
    • (2006) J Clin Oncol , vol.24 , pp. 2428-2436
    • Tanner, M.1    Isola, J.2    Wiklund, T.3
  • 12
    • 0031775808 scopus 로고    scopus 로고
    • Predictive value of topoisomerase IIalpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer
    • Jarvinen TA, Holli K, Kuukasjarvi T, et al. Predictive value of topoisomerase IIalpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer. Br J Cancer 1998;77:2267-2273.
    • (1998) Br J Cancer , vol.77 , pp. 2267-2273
    • Jarvinen, T.A.1    Holli, K.2    Kuukasjarvi, T.3
  • 13
    • 0033870292 scopus 로고    scopus 로고
    • Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer
    • Jarvinen TA, Tanner M, Rantanen V, et al. Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am J Pathol 2000;156:839-847.
    • (2000) Am J Pathol , vol.156 , pp. 839-847
    • Jarvinen, T.A.1    Tanner, M.2    Rantanen, V.3
  • 14
    • 65549158566 scopus 로고    scopus 로고
    • Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy
    • O'Malley FP, Chia S, Tu D, et al. Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy. J Natl Cancer Inst 2009;101:644-650.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 644-650
    • O'Malley, F.P.1    Chia, S.2    Tu, D.3
  • 15
    • 0036554731 scopus 로고    scopus 로고
    • Amplification and overexpression of topoisomerase IIalpha predict response to anthracycline-based therapy in locally advanced breast cancer
    • Coon JS, Marcus E, Gupta-Burt S, et al. Amplification and overexpression of topoisomerase IIalpha predict response to anthracycline-based therapy in locally advanced breast cancer. Clin Cancer Res 2002;8: 1061-1067.
    • (2002) Clin Cancer Res , vol.8 , pp. 1061-1067
    • Coon, J.S.1    Marcus, E.2    Gupta-Burt, S.3
  • 16
    • 73949150777 scopus 로고    scopus 로고
    • Simultaneous detection of TOP2A and HER2 gene amplification by multiplex ligation dependent probe amplification in breast cancer
    • Moelans CB, de Weger RA, van Blokland MTM, et al. Simultaneous detection of TOP2A and HER2 gene amplification by multiplex ligation dependent probe amplification in breast cancer. Mod Pathol 2009; 23:62-70.
    • (2009) Mod Pathol , vol.23 , pp. 62-70
    • Moelans, C.B.1    De Weger, R.A.2    Van Blokland Mtm3
  • 17
    • 34247634643 scopus 로고    scopus 로고
    • Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
    • Holst F, Stahl PR, Ruiz C, et al. Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. Nat Genet 2007;39:655-660.
    • (2007) Nat Genet , vol.39 , pp. 655-660
    • Holst, F.1    Stahl, P.R.2    Ruiz, C.3
  • 18
    • 46249125768 scopus 로고    scopus 로고
    • Conflicting evidence on the frequency of ESR1 amplification in breast cancer
    • Albertson DG. Conflicting evidence on the frequency of ESR1 amplification in breast cancer. Nat Genet 2008;40:821-822.
    • (2008) Nat Genet , vol.40 , pp. 821-822
    • Albertson, D.G.1
  • 19
    • 34447295638 scopus 로고    scopus 로고
    • Chromogenic and fluorescent in situ hybridization in breast cancer
    • Lambros MB, Natrajan R, Reis-Filho JS. Chromogenic and fluorescent in situ hybridization in breast cancer. Hum Pathol 2007;38:1105-1122.
    • (2007) Hum Pathol , vol.38 , pp. 1105-1122
    • Lambros, M.B.1    Natrajan, R.2    Reis-Filho, J.S.3
  • 20
    • 43149126354 scopus 로고    scopus 로고
    • CCND1 amplification and cyclin D1 expression in breast cancer and their relation with proteomic subgroups and patient outcome
    • Elsheikh S, Green AR, Aleskandarany MA, et al. CCND1 amplification and cyclin D1 expression in breast cancer and their relation with proteomic subgroups and patient outcome. Breast Cancer Res Treat 2008;109:325-335.
    • (2008) Breast Cancer Res Treat , vol.109 , pp. 325-335
    • Elsheikh, S.1    Green, A.R.2    Aleskandarany, M.A.3
  • 21
    • 2342656419 scopus 로고    scopus 로고
    • Deciphering a subgroup of breast carcinomas with putative progression of grade during carcinogenesis revealed by comparative genomic hybridisation (CGH) and immu-nohistochemistry
    • Korsching E, Packeisen J, Helms MW, et al. Deciphering a subgroup of breast carcinomas with putative progression of grade during carcinogenesis revealed by comparative genomic hybridisation (CGH) and immu-nohistochemistry. Br J Cancer 2004;90:1422-1428.
    • (2004) Br J Cancer , vol.90 , pp. 1422-1428
    • Korsching, E.1    Packeisen, J.2    Helms, M.W.3
  • 22
    • 1342269684 scopus 로고    scopus 로고
    • In lymph node-negative invasive breast carcinomas, specific chromosomal aberrations are strongly associated with high mitotic activity and predict outcome more accurately than grade, tumour diameter, and oestrogen receptor
    • Janssen EA, Baak JP, Guervos MA, et al. In lymph node-negative invasive breast carcinomas, specific chromosomal aberrations are strongly associated with high mitotic activity and predict outcome more accurately than grade, tumour diameter, and oestrogen receptor. J Pathol 2003;201:555-561.
    • (2003) J Pathol , vol.201 , pp. 555-561
    • Janssen, E.A.1    Baak, J.P.2    Guervos, M.A.3
  • 23
    • 59449094654 scopus 로고    scopus 로고
    • Molecular characterization of breast cancer with high-resolution oligonucleo-tide comparative genomic hybridization array
    • Andre F, Job B, Dessen P, et al. Molecular characterization of breast cancer with high-resolution oligonucleo-tide comparative genomic hybridization array. Clin Cancer Res 2009;15:441-451.
    • (2009) Clin Cancer Res , vol.15 , pp. 441-451
    • Andre, F.1    Job, B.2    Dessen, P.3
  • 24
    • 3543023204 scopus 로고    scopus 로고
    • Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification
    • Schouten JP, McElgunn CJ, Waaijer R, et al. Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res 2002;30:e57.
    • (2002) Nucleic Acids Res , vol.30
    • Schouten, J.P.1    McElgunn, C.J.2    Waaijer, R.3
  • 25
    • 33747358366 scopus 로고    scopus 로고
    • Comparison of multiplex ligation dependent probe amplification to immunohistochemistry for assessing HER-2/neu amplification in invasive breast cancer
    • Purnomosari D, Aryandono T, Setiaji K, et al. Comparison of multiplex ligation dependent probe amplification to immunohistochemistry for assessing HER-2/neu amplification in invasive breast cancer. Biotech Histochem 2006;81:79-85.
    • (2006) Biotech Histochem , vol.81 , pp. 79-85
    • Purnomosari, D.1    Aryandono, T.2    Setiaji, K.3
  • 26
    • 58149380017 scopus 로고    scopus 로고
    • HER-2/neu amplification testing in breast cancer by multiplex ligation-dependent probe amplification in comparison with immunohistochemistry and in situ hybridization
    • Moelans CB, de Weger RA, van Blokland MT, et al. HER-2/neu amplification testing in breast cancer by multiplex ligation-dependent probe amplification in comparison with immunohistochemistry and in situ hybridization. Cell Oncol 2009;31:1-10.
    • (2009) Cell Oncol , vol.31 , pp. 1-10
    • Moelans, C.B.1    De Weger, R.A.2    Van Blokland, M.T.3
  • 27
    • 59249106279 scopus 로고    scopus 로고
    • HER-2/neu amplification testing in breast cancer by multiplex ligation-dependent probe amplification: Influence of manual-and laser microdissection
    • Moelans CB, de Weger RA, Ezendam C, et al. HER-2/neu amplification testing in breast cancer by multiplex ligation-dependent probe amplification: influence of manual-and laser microdissection. BMC Cancer 2009;9:4.
    • (2009) BMC Cancer , vol.9 , pp. 4
    • Moelans, C.B.1    De Weger, R.A.2    Ezendam, C.3
  • 28
    • 3142630226 scopus 로고    scopus 로고
    • Prognostic value of proliferation in invasive breast cancer: A review
    • van Diest PJ, van der Wall E, Baak JP. Prognostic value of proliferation in invasive breast cancer: a review. J Clin Pathol 2004;57:675-681.
    • (2004) J Clin Pathol , vol.57 , pp. 675-681
    • Van Diest, P.J.1    Van Der Wall, E.2    Baak, J.P.3
  • 29
    • 0037151917 scopus 로고    scopus 로고
    • No consent should be needed for using leftover body material for scientific purposes
    • van Diest PJ. No consent should be needed for using leftover body material for scientific purposes. BMJ 2002;325:648-651.
    • (2002) BMJ , vol.325 , pp. 648-651
    • Van Diest, P.J.1
  • 30
    • 0026772950 scopus 로고
    • Reproduci-bility of mitosis counting in 2469 breast cancer specimens: Results from the Multicenter Morphometric Mammary Carcinoma Project
    • van Diest PJ, Baak JP, Matze-Cok P, et al. Reproduci-bility of mitosis counting in 2469 breast cancer specimens: results from the Multicenter Morphometric Mammary Carcinoma Project. Hum Pathol 1992;23: 603-607.
    • (1992) Hum Pathol , vol.23 , pp. 603-607
    • Van Diest, P.J.1    Baak, J.P.2    Matze-Cok, P.3
  • 31
    • 5044227573 scopus 로고    scopus 로고
    • Dosage analysis of cancer predisposition genes by multiplex ligation-dependent probe amplification
    • Bunyan DJ, Eccles DM, Sillibourne J, et al. Dosage analysis of cancer predisposition genes by multiplex ligation-dependent probe amplification. Br J Cancer 2004;91:1155-1159.
    • (2004) Br J Cancer , vol.91 , pp. 1155-1159
    • Bunyan, D.J.1    Eccles, D.M.2    Sillibourne, J.3
  • 32
    • 47749143709 scopus 로고    scopus 로고
    • MLPAna-lyzer: Data analysis tool for reliable automated normalization of MLPA fragment data
    • Coffa J, van de Wiel MA, Diosdado B, et al. MLPAna-lyzer: data analysis tool for reliable automated normalization of MLPA fragment data. Cell Oncol 2008; 30:323-335.
    • (2008) Cell Oncol , vol.30 , pp. 323-335
    • Coffa, J.1    Van De Wiel, M.A.2    Diosdado, B.3
  • 33
    • 9244222241 scopus 로고    scopus 로고
    • Prognostic relevance of gene amplifications and coamplifications in breast cancer
    • Al-Kuraya K, Schraml P, Torhorst J, et al. Prognostic relevance of gene amplifications and coamplifications in breast cancer. Cancer Res 2004;64:8534-8540.
    • (2004) Cancer Res , vol.64 , pp. 8534-8540
    • Al-Kuraya, K.1    Schraml, P.2    Torhorst, J.3
  • 34
    • 0034652452 scopus 로고    scopus 로고
    • Relating genotype and phenotype in breast cancer: An analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations
    • Cuny M, Kramar A, Courjal F, et al. Relating genotype and phenotype in breast cancer: an analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations. Cancer Res 2000;60:1077-1083.
    • (2000) Cancer Res , vol.60 , pp. 1077-1083
    • Cuny, M.1    Kramar, A.2    Courjal, F.3
  • 35
    • 33750744107 scopus 로고    scopus 로고
    • Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers
    • Letessier A, Sircoulomb F, Ginestier C, et al. Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers. BMC Cancer 2006;6:245.
    • (2006) BMC Cancer , vol.6 , pp. 245
    • Letessier, A.1    Sircoulomb, F.2    Ginestier, C.3
  • 36
    • 2442564320 scopus 로고    scopus 로고
    • Correlation of amplification and overexpression of the c-myc onco-gene in high-grade breast cancer: FISH, in situ hybridisation and immunohistochemical analyses
    • Blancato J, Singh B, Liu A, et al. Correlation of amplification and overexpression of the c-myc onco-gene in high-grade breast cancer: FISH, in situ hybridisation and immunohistochemical analyses. Br J Cancer 2004;90:1612-1619.
    • (2004) Br J Cancer , vol.90 , pp. 1612-1619
    • Blancato, J.1    Singh, B.2    Liu, A.3
  • 37
    • 33845191779 scopus 로고    scopus 로고
    • Genomic and transcriptional aberrations linked to breast cancer pathophysiologies
    • Chin K, DeVries S, Fridlyand J, et al. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 2006;10:529-541.
    • (2006) Cancer Cell , vol.10 , pp. 529-541
    • Chin, K.1    Devries, S.2    Fridlyand, J.3
  • 38
    • 0041662219 scopus 로고    scopus 로고
    • DNA copy number changes detected by comparative genomic hybridization and their association with clinicopatho-logic parameters in breast tumors
    • Cingoz S, Altungoz O, Canda T, et al. DNA copy number changes detected by comparative genomic hybridization and their association with clinicopatho-logic parameters in breast tumors. Cancer Genet Cytogenet 2003;145:108-114.
    • (2003) Cancer Genet Cytogenet , vol.145 , pp. 108-114
    • Cingoz, S.1    Altungoz, O.2    Canda, T.3
  • 39
    • 33645960993 scopus 로고    scopus 로고
    • Activation of multiple cancer-associated genes at the ERBB2 amplicon in breast cancer
    • Kauraniemi P, Kallioniemi A. Activation of multiple cancer-associated genes at the ERBB2 amplicon in breast cancer. Endocr Relat Cancer 2006;13:39-49.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 39-49
    • Kauraniemi, P.1    Kallioniemi, A.2
  • 40
    • 67349202517 scopus 로고    scopus 로고
    • Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis
    • Kwek SS, Roy R, Zhou H, et al. Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis. Oncogene 2009; 28:1892-1903.
    • (2009) Oncogene , vol.28 , pp. 1892-1903
    • Kwek, S.S.1    Roy, R.2    Zhou, H.3
  • 41
    • 9244248684 scopus 로고    scopus 로고
    • Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes
    • Loo LW, Grove DI, Williams EM, et al. Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes. Cancer Res 2004; 64:8541-8549.
    • (2004) Cancer Res , vol.64 , pp. 8541-8549
    • Loo, L.W.1    Grove, D.I.2    Williams, E.M.3
  • 42
    • 33646559516 scopus 로고    scopus 로고
    • Breast tumor copy number aberration phenotypes and genomic instability
    • Fridlyand J, Snijders AM, Ylstra B, et al. Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer 2006;6:96.
    • (2006) BMC Cancer , vol.6 , pp. 96
    • Fridlyand, J.1    Snijders, A.M.2    Ylstra, B.3
  • 43
    • 35448972855 scopus 로고    scopus 로고
    • Gene amplification and overexpression of PRDM14 in breast cancers
    • Nishikawa N, Toyota M, Suzuki H, et al. Gene amplification and overexpression of PRDM14 in breast cancers. Cancer Res 2007;67:9649-9657.
    • (2007) Cancer Res , vol.67 , pp. 9649-9657
    • Nishikawa, N.1    Toyota, M.2    Suzuki, H.3
  • 44
    • 33745435244 scopus 로고    scopus 로고
    • Trastuzumab sensitivity of breast cancer with co-amplification of HER2 and cMYC suggests pro-apoptotic function of dysregulated cMYC in vivo [abstract]
    • Abstract 46
    • Kim C, Bryant J, Horne Z, et al. Trastuzumab sensitivity of breast cancer with co-amplification of HER2 and cMYC suggests pro-apoptotic function of dysregulated cMYC in vivo [abstract]. Breast Cancer Res Treat 2005;94(Suppl 1):S6. Abstract 46.
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.SUPPL. 1
    • Kim, C.1    Bryant, J.2    Horne, Z.3
  • 45
    • 33646109555 scopus 로고    scopus 로고
    • Cyclin e expression in breast cancer correlates with negative steroid receptor status, HER2 expression, tumor grade and proliferation
    • Potemski P, Kusinska R, Watala C, et al. Cyclin E expression in breast cancer correlates with negative steroid receptor status, HER2 expression, tumor grade and proliferation. J Exp Clin Cancer Res 2006;25: 59-64.
    • (2006) J Exp Clin Cancer Res , vol.25 , pp. 59-64
    • Potemski, P.1    Kusinska, R.2    Watala, C.3
  • 46
    • 13844281018 scopus 로고    scopus 로고
    • Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays
    • Callagy G, Pharoah P, Chin SF, et al. Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays. J Pathol 2005;205:388-396.
    • (2005) J Pathol , vol.205 , pp. 388-396
    • Callagy, G.1    Pharoah, P.2    Chin, S.F.3
  • 47
    • 42649110664 scopus 로고    scopus 로고
    • Genetic alterations of CCND1 and EMSY in breast cancers
    • Kirkegaard T, Nielsen KV, Jensen LB, et al. Genetic alterations of CCND1 and EMSY in breast cancers. Histopathology 2008;52:698-705.
    • (2008) Histopathology , vol.52 , pp. 698-705
    • Kirkegaard, T.1    Nielsen, K.V.2    Jensen, L.B.3
  • 48
    • 10744233204 scopus 로고    scopus 로고
    • EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
    • Hughes-Davies L, Huntsman D, Ruas M, et al. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 2003;115:523-535.
    • (2003) Cell , vol.115 , pp. 523-535
    • Hughes-Davies, L.1    Huntsman, D.2    Ruas, M.3
  • 49
    • 0031031998 scopus 로고    scopus 로고
    • Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value
    • van Diest PJ, Michalides RJ, Jannink L, et al. Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value. Am J Pathol 1997;150:705-711.
    • (1997) Am J Pathol , vol.150 , pp. 705-711
    • Van Diest, P.J.1    Michalides, R.J.2    Jannink, L.3
  • 50
    • 34548646565 scopus 로고    scopus 로고
    • EGFR gene and protein expression in breast cancers
    • Park K, Han S, Shin E, et al. EGFR gene and protein expression in breast cancers. Eur J Surg Oncol 2007;33:956-960.
    • (2007) Eur J Surg Oncol , vol.33 , pp. 956-960
    • Park, K.1    Han, S.2    Shin, E.3
  • 51
    • 34548833289 scopus 로고    scopus 로고
    • MYC amplification in breast cancer: A chromogenic in situ hybridisation study
    • Rodriguez-Pinilla SM, Jones RL, Lambros MB, et al. MYC amplification in breast cancer: a chromogenic in situ hybridisation study. J Clin Pathol 2007;60: 1017-1023.
    • (2007) J Clin Pathol , vol.60 , pp. 1017-1023
    • Rodriguez-Pinilla, S.M.1    Jones, R.L.2    Lambros, M.B.3
  • 52
    • 0036146659 scopus 로고    scopus 로고
    • E-cadherin and loss of heterozyg-osity at chromosome 16 in breast carcinogenesis: Different genetic pathways in ductal and lobular breast cancer?
    • Cleton-Jansen AM. E-cadherin and loss of heterozyg-osity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer? Breast Cancer Res 2002;4:5-8.
    • (2002) Breast Cancer Res , vol.4 , pp. 5-8
    • Cleton-Jansen, A.M.1
  • 53
    • 33846089951 scopus 로고    scopus 로고
    • TRAF4 overexpression is a common characteristic of human carcinomas
    • Camilleri-Broet S, Cremer I, Marmey B, et al. TRAF4 overexpression is a common characteristic of human carcinomas. Oncogene 2007;26:142-147.
    • (2007) Oncogene , vol.26 , pp. 142-147
    • Camilleri-Broet, S.1    Cremer, I.2    Marmey, B.3
  • 54
    • 43049128509 scopus 로고    scopus 로고
    • The LIM and SH3 domain protein family: Structural proteins or signal transducers or both?
    • Grunewald TG, Butt E. The LIM and SH3 domain protein family: structural proteins or signal transducers or both? Mol Cancer 2008;7:31.
    • (2008) Mol Cancer , vol.7 , pp. 31
    • Grunewald, T.G.1    Butt, E.2
  • 55
    • 13044271699 scopus 로고    scopus 로고
    • Amplification and over-expression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer
    • Zhu Y, Qi C, Jain S, et al. Amplification and over-expression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Proc Natl Acad Sci USA 1999;96:10848-10853.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10848-10853
    • Zhu, Y.1    Qi, C.2    Jain, S.3
  • 56
    • 42549111727 scopus 로고    scopus 로고
    • Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines
    • Arriola E, Marchio C, Tan DS, et al. Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines. Lab Invest 2008;88:491-503.
    • (2008) Lab Invest , vol.88 , pp. 491-503
    • Arriola, E.1    Marchio, C.2    Tan, D.S.3
  • 57
    • 61449122221 scopus 로고    scopus 로고
    • Frequent amplifications and deletions of G1/S-phase transition genes CCND1 and MYC in early breast cancers: A potential role in G1/S escape
    • Jensen LB, Bartlett JM, Witton CJ, et al. Frequent amplifications and deletions of G1/S-phase transition genes, CCND1 and MYC in early breast cancers: a potential role in G1/S escape. Cancer Biomark 2009; 5:41-49.
    • (2009) Cancer Biomark , vol.5 , pp. 41-49
    • Jensen, L.B.1    Bartlett, J.M.2    Witton, C.J.3
  • 59
    • 0030962953 scopus 로고    scopus 로고
    • A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines
    • Sen S, Zhou H, White RA. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 1997;14:2195-2200.
    • (1997) Oncogene , vol.14 , pp. 2195-2200
    • Sen, S.1    Zhou, H.2    White, R.A.3
  • 60
    • 34447325266 scopus 로고    scopus 로고
    • FGFR1 amplification in breast carcinomas: A chromogenic in situ hybridisation analysis
    • Elbauomy ES, Green AR, Lambros MB, et al. FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis. Breast Cancer Res 2007; 9:R23.
    • (2007) Breast Cancer Res , vol.9
    • Elbauomy, E.S.1    Green, A.R.2    Lambros, M.B.3
  • 61
    • 0035304423 scopus 로고    scopus 로고
    • Mapping the chromosome 16 cadherin gene cluster to a minimal deleted region in ductal breast cancer
    • Chalmers IJ, Aubele M, Hartmann E, et al. Mapping the chromosome 16 cadherin gene cluster to a minimal deleted region in ductal breast cancer. Cancer Genet Cytogenet 2001;126:39-44.
    • (2001) Cancer Genet Cytogenet , vol.126 , pp. 39-44
    • Chalmers, I.J.1    Aubele, M.2    Hartmann, E.3
  • 62
    • 32944475493 scopus 로고    scopus 로고
    • Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group
    • Knoop AS, Knudsen H, Balslev E, et al. Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. J Clin Oncol 2005;23:7483-7490.
    • (2005) J Clin Oncol , vol.23 , pp. 7483-7490
    • Knoop, A.S.1    Knudsen, H.2    Balslev, E.3
  • 63
    • 0036091354 scopus 로고    scopus 로고
    • HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophospha-mide, methotrexate, and 5-fluorouracil
    • Di Leo A, Gancberg D, Larsimont D, et al. HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophospha-mide, methotrexate, and 5-fluorouracil. Clin Cancer Res 2002;8:1107-1116.
    • (2002) Clin Cancer Res , vol.8 , pp. 1107-1116
    • Di Leo, A.1    Gancberg, D.2    Larsimont, D.3


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