Distinct regulation of intrinsic apoptosis in benign and malignant thyroid tumours

Hormone and Metabolic Research

Volumn 42, Issue 8, 2010, Pages 553-556

  Weidinger, C ^a   Karger, S ^a   Krause, K ^a   Schierle, K ^a   Steinert, F ^b   Gimm, O ^c   Dralle, H ^c   Fuhrer, D ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b Helios Clinic Schkeuditz   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

apoptosis; Bad; Caspase3; Caspase3s; thyroid cancer; xIAP

Indexed keywords

BETA ACTIN; CASPASE 3; MESSENGER RNA; PROTEIN BAD; X LINKED INHIBITOR OF APOPTOSIS;

ALTERNATIVE RNA SPLICING; APOPTOSIS; ARTICLE; BENIGN TUMOR; CANCER CELL; CARCINOGENESIS; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME LOCALIZATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; THYROID CANCER; THYROID FOLLICULAR CARCINOMA; THYROID PAPILLARY CARCINOMA; THYROID TUMOR; TRANSCRIPTION REGULATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY;

APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CASPASE 3; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; RNA, MESSENGER; THYROID NEOPLASMS;

EID: 77954232710     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0030-1253374     Document Type: Article

References (12)

1. Tokunaga E, Oki E, Egashira A, Sadanaga N, Morita M, Kakeji Y, Maehara Y. Deregulation of the Akt pathway in human cancer. Curr Cancer Drug Targets 2008 8 27-36
2. Vegran F, Boidot R, Oudin C, Riedinger JM, Bonnetain F, Lizard-Nacol S. Overexpression of caspase-3s splice variant in locally advanced breast carcinoma is associated with poor response to neoadjuvant chemotherapy. Clin Cancer Res 2006 12 5794-5800
3. Li J, Yuan J. Caspases in apoptosis and beyond. Oncogene 2008 27 6194-6206
4. Kamada S, Kikkawa U, Tsujimoto Y, Hunter T. Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). J Biol Chem 2005 280 857-860
5. Huang Y, Shin NH, Sun Y, Wang KK. Molecular cloning and characterization of a novel caspase-3 variant that attenuates apoptosis induced by proteasome inhibition. Biochem Biophys Res Commun 2001 283 762-769
6. Eckelman BP, Salvesen GS, Scott FL. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep 2006 7 988-994
7. Levine B, Sinha S, Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 2008 4 600-606
8. Karger S, Weidinger C, Krause K, Sheu SY, Aigner T, Gimm O, Schmid K, Dralle H, Fuhrer D. FOXO3a: a novel player in thyroid carcinogenesis? Endocr Relat Cancer 2009 16 189-199
9. Krause K, Eszlinger M, Gimm O, Karger S, Engelhardt C, Dralle H, Fuhrer D. TFF3-based candidate gene discrimination of benign and malignant thyroid tumors in a region with borderline iodine deficiency. J Clin Endocrinol Metab 2008 93 1390-1393
10. Krause K, Karger S, Gimm O, Sheu SY, Dralle H, Tannapfel A, Schmid KW, Dupuy C, Fuhrer D. Characterisation of DEHAL1 expression in thyroid pathologies. Eur J Endocrinol 2007 156 1-8
11. Fuhrer D, Eszlinger M, Karger S, Krause K, Engelhardt C, Hasenclever D, Dralle H, Paschke R. Evaluation of insulin-like growth factor II, cyclooxygenase-2, ets-1 and thyroid-specific thyroglobulin mRNA expression in benign and malignant thyroid tumours. Eur J Endocrinol 2005 152 785-790
12. Sherman SI. Tyrosine kinase inhibitors and the thyroid. Best Pract Res Clin Endocrinol Metab 2009 23 713-722