Characteristics of symptomatic reflux episodes in patients with non-erosive reflux disease who have a positive symptom index on proton pump inhibitor therapy

Digestion

Volumn 82, Issue 3, 2010, Pages 156-161

  Iwakiri, Katsuhiko ^a,b   Sano, Hirohito ^a   Tanaka, Yuriko ^a   Kawami, Noriyuki ^a   Umezawa, Mariko ^a   Futagami, Seiji ^a   Hoshihara, Yoshio ^a,c   Nomura, Tsutomu ^b   Miyashita, Masao ^b   Sakamoto, Choitsu ^a  

^a Department of Medicine   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c Ministry of Economy Trade and Industry   (Japan)

Author keywords

Impedance pH monitoring; Non erosive reflux disease; Persistent heartburn; Proximal reflux; Symptomatic reflux episodes

Indexed keywords

2 [[(2 PYRIDYL)METHYL]SULFINYL]BENZIMIDAZOLE DERIVATIVE; PROTON PUMP INHIBITOR; RABEPRAZOLE;

ADULT; AGED; ESOPHAGEAL PH MONITORING; FEMALE; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMAN; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PERCEPTION; PSYCHOLOGY;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ADULT; AGED; ESOPHAGEAL PH MONITORING; FEMALE; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMANS; MALE; MIDDLE AGED; PERCEPTION; PROTON PUMP INHIBITORS; RABEPRAZOLE;

EID: 77954221110     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000309483     Document Type: Conference Paper

References (15)

1. Sifrim D, Castell D, Dent J, Kahrilas PJ: Gastro- oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux. Gut 2004; 53: 1024-1031.
2. Bredenoord AJ, Weusten BL, Timmer R, Smout AJ: Reproducibility of multichannel intraluminal electrical impedance monitoring of gastroesophageal reflux. Am J Gastroenterol 2005; 100: 265-269.
3. Tutuian R, Vela MF, Shay SS, Castell DO: Multichannel intraluminal impedance in esophageal function testing and gastroesophageal reflux monitoring. J Clin Gastroenterol 2003; 37: 206-215. (Pubitemid 37010914)
4. Shay S, Tutuian R, Sifrim D, Vela M, Wise J, Balaji N, Zhang X, Adhami T, Murray J, Peter J, Castell DO: Twenty-four hour ambulatory simultaneous impedance and pH monitoring: a multicenter report of normal values from 60 healthy volunteers. Am J Gastroenterol 2004; 99: 1037-1043.
5. Bredenoord AJ, Weusten BLAM, Curvers WL, Timmer R, Smout AJPM: Determinants of perception of heartburn and regurgitation. Gut 2006; 55: 313-318.
6. Weusten BL, Akkermans LM, van Berge- Henegouwen GP, Smout AJ: Symptom perception in gastroesophageal reflux disease is dependent on spatiotemporal reflux characteristics. Gastroenterology 1995; 108: 1739-1744.
7. Zerbib F, Duriez A, Roman S, Capdepont M, Mion F: Determinants of gastro-oesophageal reflux perception in patients with persistent symptoms despite proton pump inhibitors. Gut 2008; 57: 156-160.
8. Tutuian R, MF Vela, Hill EG, Mainie I, Agrawal A, Castell DO: Characteristics of symptomatic reflux episodes on acid suppressive therapy. Am J Gastroenterol 2008; 103: 1090-1096.
9. Iwakiri K, Kawami N, Sano H, Tanaka Y, Umezawa M, Kotoyori M, Hoshihara Y, Sakamoto C: Acid and non-acid reflux in Japanese patients with non-erosive reflux disease with persistently reflux symptoms, despite taking a double-dose of proton pump inhibitor: a study using combined pH-impedance monitoring. J Gastroenterol 2009; 44: 708-712.
10. Wiener GJ, Richter JE, Copper JB, Wu WC, Castell DO: The symptom index: a clinically important parameter of ambulatory 24-hour esophageal pH monitoring. Am J Gastroenterol 1988; 83: 358-361.
11. Cicala M, Emerenziani S, Caviglia R, Guarino MPL, Vavassori P, Ribolsi M, Carotti S, Petitti T, Pallone F: Intra-oesophageal distribution and perception of acid reflux in patients with non-erosive gastro-oesophageal reflux disease. Alimernt Pharmacol Ther 2003; 18: 605-613.
12. Miwa H, Minoo T, Hojo M, Yaginuma R, Nagahara A, Kawabe M, Ohkawa A, Asaoka D, Kurosawa A, Ohkusa T, Sato N: Oesophageal hypersensitivity in Japanese patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2004; 20(suppl 1):112-117.
13. Emerenziani S, Ribolsi M, Sifrim D, Blondeau K, Cicala M: Regional oesophageal sensitivity to acid and weakly acidic reflux in patients with non-erosive reflux disease. Neurogastroenterol Motil 2009; 21: 253-258.
14. Sifrim D, Mittal R, Fass R, Smout A, Castell D, Tack J, Gregersen H: Acidity and volume of the refluxate in the genesis of gastro-oesophageal reflux disease symptoms. Aliment Pharmacol Ther 2007; 25: 1003-1015.
15. Iwakiri K, Hayashi Y, Kotoyori M, Tanaka Y, Kawami N, Sano H, Takubo K, Sakamoto C, Holloway RH: Defective triggering of secondary peristalsis in patients with non-erosive reflux disease. J Gastroenterol Hepatol 2007; 22: 2208-2211.