Statistical methods to estimate treatment effects from multichannel electroencephalography (EEG) data in clinical trials

Journal of Neuroscience Methods

Volumn 190, Issue 2, 2010, Pages 248-257

  Ma, Junshui ^a   Wang, Shubing ^a   Raubertas, Richard ^a   Svetnik, Vladimir ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Clinical EEG; EEG data analysis; Mixed effects model; Multichannel EEG; Spatial smooth; Spherical harmonics

Indexed keywords

DEXTROMETHORPHAN; PLACEBO; RILUZOLE;

ARTICLE; CLINICAL RESEARCH; CLINICAL TRIAL; DATA ANALYSIS; DRUG RESEARCH; ELECTROENCEPHALOGRAM; HUMAN; NONPARAMETRIC TEST; PARAMETRIC TEST; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TREATMENT RESPONSE; ALGORITHM; BRAIN; CLINICAL TRIAL (TOPIC); DEVICES; DRUG EFFECTS; ELECTROENCEPHALOGRAPHY; PHYSIOLOGY; PROCEDURES; SIGNAL PROCESSING;

ALGORITHMS; BRAIN; CLINICAL TRIALS AS TOPIC; DATA INTERPRETATION, STATISTICAL; ELECTROENCEPHALOGRAPHY; HUMANS; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 77954214198     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2010.05.013     Document Type: Article

References (15)

1. Crager M.R. Analysis of covariance in parallel-group clinical trials with pretreatment baselines. Biometrics 1987, 43:895-901.
2. Cressie N. Statistics for spatial data 1993, Wiley Interscience.
3. Dumermuth G., Gasser T., Langer B. Aspects of EEG analysis in the frequency domain. Computerized EEG analysis 1975, 429-457. Fischer, Stuttgart. G. Dolce, H. Kiinkel (Eds.).
4. Ferbera G., Abtb K., Fichtec K., Luthringerd R. IPEG guideline on statistical design and analysis for pharmacodynamic trials. Neuropsychobiology 1999, 39:92-100.
5. Gasser T. Statistical handling of EEG data. Pharmakopsychiatrie 1979, 12:210-219.
6. John E.R., Prichep L.S., Fridman J., Easton P. Neurometrics: computer-assisted differential diagnosis of brain dysfunctions. Science 1988, 239(4836):162-169.
7. Liu G.F., Lu K., Mogg R., Mallick M., Mehrotra D.V. Should baseline be a covariate or dependent variable in analyses of change from baseline in clinical trials?. Stat Med 2009, 28:2509-2530.
8. Lopes da Silva F. Computer-assisted EEG diagnosis: pattern recognition and brain mapping. Electroencephalography: basic principles, clinical applications, and related fields 2005, 1233-1263. Lippincott Williams & Wilkins. 5th ed. E. Niedermeyer, F. Lopes da Silva (Eds.).
9. Lopes da Silva F. EEG analysis: theory and practice. Electroencephalography: basic principles, clinical applications, and related fields 2005, 1199-1231. Lippincott Williams & Wilkins. 5th ed. E. Niedermeyer, F. Lopes da Silva (Eds.).
10. Lopes da Silva F., Van Rotterdam A. Biophysical aspects of EEG and magnetoencephalogram generation. Electroencephalography: basic principles, clinical applications, and related fields 2005, 107-125. Lippincott Williams & Wilkins. 5th ed. E. Niedermeyer, F. Lopes da Silva (Eds.).
11. Nunez P.L., Srinivasan R. Electric fields of the brain: the macrophysics of EEG 2006, Oxford University Press, Inc., New York. 2nd ed.
12. Pinheiro J.C., Bates D.M. Mixed-effects models in S and S-Plus 2000, Springer-Verlag, New York.
13. Venables W.N., Ripley B.D. Modern applied statistics with S 2002, Springer, New York. 4th ed.
14. Yamada K., Isotani T., Irisawa S., Yoshimura M., Tajika A., Yagyu T., et al. EEG global field power spectrum changes after a single dose of atypical antipsychotics in healthy volunteers. Brain Topogr. 2004, 16(4):281-285.
15. Yoshimura M., Koenig T., Irisawa S., Isotani T., Yamada K., Kikuchi M., et al. A pharmaco-EEG study on antipsychotic drugs in healthy volunteers. Psychopharmacology 2007, 191:995-1004.