Associations between genetic variants in the ace, agt, agtr1 and agtr2 genes and renal function in the multi-ethnic study of atherosclerosis

American Journal of Nephrology

Volumn 32, Issue 2, 2010, Pages 156-162

  Campbell, Catherine Y ^a   Fang, Belle F ^b   Guo, Xiuqing ^b   Peralta, Carmen A ^c   Psaty, Bruce M ^d,e   Rich, Stephen S ^f   Young, J Hunter ^a   Coresh, Josef ^a   Kramer, Holly J ^g   Rotter, Jerome I ^b   Post, Wendy S ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e CENTER FOR HEALTH STUDIES   (United States)

^f UNIVERSITY OF VIRGINIA   (United States)

^g LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Ace; Agt; Agtr1; Agtr2; Albuminuria; Creatinine clearance epidemiology; Genetics; Renin Angiotensin

Indexed keywords

ALBUMIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSINOGEN; CREATININE; CYSTATIN C; GLUCOSE; DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AFRICAN AMERICAN; AGT GENE; AGTR1 GENE; AGTR2 GENE; ARTICLE; ATHEROSCLEROSIS; CHINESE; COHORT ANALYSIS; CREATININE BLOOD LEVEL; CROSS-SECTIONAL STUDY; DIABETIC NEPHROPATHY; DIASTOLIC BLOOD PRESSURE; ESTIMATED GLOMERULAR FILTRATION RATE; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HISPANIC; HUMAN; HYPERTENSION; KIDNEY FUNCTION; KIDNEY FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OBSERVATIONAL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; URINALYSIS; X CHROMOSOME; AGED; ETHNIC GROUP; ETHNOLOGY; GENETICS; KIDNEY DISEASE; PHENOTYPE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

AGED; ANGIOTENSINOGEN; ATHEROSCLEROSIS; COHORT STUDIES; ETHNIC GROUPS; FEMALE; GENETIC VARIATION; HUMANS; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; MALE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RENIN-ANGIOTENSIN SYSTEM;

EID: 77954211166     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000315866     Document Type: Article

References (26)

1. Hall JE, Mizelle HL, Woods LL: The reninangiotensin system and long-Term regulation of arterial pressure. J Hypertens 1986; 4: 387-397.
2. Sealy JE, Laragh JH: The renin-Angiotensinaldosterone system for normal regulation of blood pressure and sodium and potassium homeostasis; in Laragh JH, Brenner BM (eds): Hypertension: Pathophysiology, Diagnosis, and Management. New York, Raven Press, 1995.
3. Fabris B, Bortoletto M, Candido R, Barbone F, Cattin MR, Calci M, Scanferla F, Tizzoni L, Giacca M, Carretta R: Genetic polymorphisms of the renin-Angiotensin-Aldosterone system and renal insufficiency in essential hypertension. J Hypertens 2005; 23: 309-316.
4. Hsu CC, Bray MS, Kao WH, Pankow JS, Boerwinkle E, Coresh J: Genetic variation of the renin-Angiotensin system and chronic kidney disease progression in black individuals in the atherosclerosis risk in communities study. J Am Soc Nephrol 2006; 17: 504-512.
5. Osawa N, Koya D, Araki S, Uzu T, Tsunoda T, Kashiwagi A, Nakamura Y, Maeda S: Combinational effect of genes for the reninangiotensin system in conferring susceptibility to diabetic nephropathy. J Hum Genet 2007; 52: 143-151.
6. Pettersson Fernholm K, Frojdo S, Fagerudd J, Thomas MC, Forsblom C, Wessman M, Groop PH: The AT2 gene may have a genderspecific effect on kidney function and pulse pressure in type I diabetic patients. Kidney Int 2006; 69: 1880-1884.
7. Prasad P, Tiwari AK, Kumar KM, Ammini AC, Gupta A, Gupta R, Sharma AK, Rao AR, Nagendra R, Chandra TS, Tiwari SC, Rastogi P, Gupta BL, Thelma BK: Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms. BMC Med Genet 2006; 7: 42.
8. Rogus JJ, Moczulski D, Freire MB, Yang Y, Warram JH, Krolewski AS: Diabetic nephropathy is associated with AGT polymorphism T235: results of a family-based study. Hypertension 1998; 31: 627-631.
9. Ruggenenti P, Bettinaglio P, Pinares F, Remuzzi G: Angiotensin converting enzyme insertion/deletion polymorphism and renoprotection in diabetic and nondiabetic nephropathies. Clin J Am Soc Nephrol 2008; 3: 1511-1525.
10. Thameem F, Voruganti VS, He X, Nath SD, Blangero J, MacCluer JW, Comuzzie AG, Abboud HE, Arar NH: Genetic variants in the renin-Angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans. Hum Genet 2008; 124: 557-559.
11. Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, Greenland P, Jacob DR Jr., Kronmal R, Liu K, Nelson JC, O?Leary D, Saad MF, Shea S, Szklo M, Tracy RP: Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol 2002; 156: 871-881.
12. McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF: Integrative predictive model of coronary artery calcification in atherosclerosis. Circulation 2009; 120: 2448-2454.
13. Kramer H, Jacobs DR Jr, Bild D, Post W, Saad MF, Detrano R, Tracy R, Cooper R, Liu K: Urine albumin excretion and subclinical cardiovascular disease. The Multi-Ethnic Study of Atherosclerosis. Hypertension 2005; 46: 38-43.
14. Moran A, Katz R, Jenny NS, Astor B, Bluemke DA, Lima JA, Siscovick D, Bertoni AG, Shlipak MG: Left ventricular hypertrophy in mild and moderate reduction in kidney function determined using cardiac magnetic resonance imaging and cystatin C: The multiethnic study of atherosclerosis (MESA). Am J Kidney Dis 2008; 52: 839-848.
15. Stevens LA, Coresh J, Schmid CH, Feldman HI, Froissart M, Kusek J, Rossert J, Van Lente F, Bruce RD , Zhang YL, Greene T, Levey AS: Estimating GFR using serum cystatin C alone and in combination with serum creatinine: A pooled analysis of 3,418 individuals with CKD. Am J Kidney Dis 2008; 51: 395-406.
16. Mattix HJ, Hsu CY, Shaykevich S, Curhan G: Use of the albumin/creatinine ratio to detect microalbuminuria: implications of sex and race. J Am Soc Nephrol 2002; 13: 1034-1039.
17. Stephens M, Smith NJ, Donnelly P: A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68: 978-989.
18. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D: Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006; 38: 904-909.
19. Jackson JE: A User?s Guide to Principal Components. Hoboken, Wiley-Interscience, 2003.
20. Davison AC, Hinkley DV: Bootstrap Methods and Their Application. Cambridge, Cambridge University Press, 1997.
21. North BV, Curtis D, Sham PC: A note on the calculation of empirical p values from Monte Carlo procedures. Am J Hum Genet 2002; 71: 439-441.
22. Gao X, Starmer J, Martin ER: A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms. Genet Epidemiol 2008; 32: 361-369.
23. Boright AP, Paterson AD, Mirea L, Bull SB, Mowjoodi A, Scherer SW, Zinman B: Genetic variation at the ACE gene is associated with persistent microalbuminuria and severe nephropathy in type 1 diabetes: The DCCT/EDIC Genetics Study. Diabetes 2005; 54: 1238-1244.
24. Stevens LA, Levey AS: Current status and future perspectives for CKD testing. Am J Kidney Dis 2009; 53:S17-S26.
25. Stevens LA, Coresh J, Greene T, Levey AS: Assessing kidney function-measured and estimated glomerular filtration rate. N Engl J Med 2006; 354: 2473-2483.
26. K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease. Am J Kidney Dis 2004; 43:S1-S290.