Two-and three-layer tablet drug delivery systems for oral sustained release of soluble and poorly soluble drugs

Drug Development and Industrial Pharmacy

Volumn 36, Issue 8, 2010, Pages 903-916

  Efentakis, M ^a   Naseef, H ^a   Vlachou, M ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Diclofenac; Furosemide; Polymers; Release kinetics; Sustained release; Two and three layer tablets

Indexed keywords

DICLOFENAC; FUROSEMIDE; GANTREZ COPOLYMER; HYDROXYPROPYLMETHYLCELLULOSE; POLYMER; POLYOX; UNCLASSIFIED DRUG; XANTHAM GUM; DELAYED RELEASE FORMULATION; DRUG CARRIER; TABLET; WATER;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; HUMAN; SUSTAINED DRUG RELEASE; ADMINISTRATION AND DOSAGE; ANALYSIS; CHEMICAL PHENOMENA; CHEMISTRY; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DIFFUSION; KINETICS; ORAL DRUG ADMINISTRATION; PROCEDURES; SOLUBILITY; TABLET;

ADMINISTRATION, ORAL; DELAYED-ACTION PREPARATIONS; DICLOFENAC; DIFFUSION; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; FUROSEMIDE; HYDROPHOBICITY; KINETICS; POLYMERS; SOLUBILITY; TABLETS; WATER; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS;

EID: 77954208865     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639040903585119     Document Type: Article

References (26)

1. Vueba M, Batista de Carvalho L, Veiga F, Sousa J, Pina M. (2005). Role of cellulose ether polymers on ibuprofen release from matrix tablets. Drug Dev Ind Pharm, 31:653-655
2. Shehab M, Richards J. (1996). Studies on the in vitro release of ibuprofen from polyethylene glycol-polyvinyl acetate mixtures liquid filled into hard gelatin capsules. Drug Dev Ind Pharm, 22:645-651 (Pubitemid 26245750)
3. Efentakis M, Vlachou M. (2000). Evaluation of high molecular weight poly(oxyethylene) [Polyox] polymer: Studies of flow properties and release rates of furosemide and captopril from controlled release hard gelatin capsules. Pharm Dev Technol, 5:339-346
4. Efentakis M, Koutlis A. (2001). Release of furosemide from multiple-unit and single unit preparations containing different viscosity grades of sodium alginate. Pharm Dev Technol, 6:91-98
5. Conte U, Maggi L. (1998). Multi-layer tablets as drug delivery devices. Pharm Technnol, 10:8-25.
6. Qiu Y, Chindambaram N, Flood K. (1998). Design and evaluation of layered diffusional matrices for zero order sustained release. Int J Pharm, 5:123-130 (Pubitemid 28252863)
7. Abdul S, Poddar S. (2004). A flexible technology for modified release of drugs: Multi-layered tablets. J Control Release, 97:393-405.
8. Song C, Labnasetwar V, Levy R. (1999). Controlled release of U-86983 from double layer biodegradable matrices: Effect of additives on release mechanism and kinetics. J Control Release, 45:177-192
9. Efentakis M, Politis S. (2006). Comparative evaluation of various structures in polymer controlled drug delivery systems and the effect of their morphology and characteristics on drug release. Eur Polym J, 42:1183-1195
10. Korsmeyer R. (2000). Diffusion controlled systems. In: Tarca P, ed. Polymers for controlled release drug delivery. Boca Raton, FL: CRC Press Inc, 15-38.
11. Zuleger S, Fassihi R, Lippold B. (2002). Polymer particle erosion controlling drug release. II. Swelling investigations to clarify the release mechanism. Int J Pharm, 247:23-37.
12. Roy D, Rohera B. (2002). Comparative evaluation of rate of hydration and matrix erosion of HEC and HPC and study of drug release from their matrices. Eur J Pharm Sci, 16:193-199
13. Ebude N, Hikal A, Wyandt M, Beer D, Miller L, Jones A. (1997). Sustained release of acetaminophen from heterogeneous matrix of tablets: Influence of polymer ratio, polymer loading and co-active on drug release. Pharm Dev Technol, 2:161-170
14. Khan K. (1975). The concept of dissolution efficiency. J Pharm Pharmacol, 27:48-50.
15. Vlachou M, Naseef H, Efentakis M. (2004). Image analysis of dimensional changes in swellable hydrophilic polymer matrices. Polym Adv Technnol, 15:683-689
16. Papadimitriou E, Buckton G, Efentakis M. (1993). Probing the mechanisms of swelling of hydroxypropylmethylcellulose matrices. Int J Pharm, 98:57-92.
17. Conte U, Maggi L. (1996). Modulation of the dissolution profiles from geomatrix multi layer matrix tablets containing drugs of different solubility. Biomaterials, 17:889-896
18. Yang L, Fassihi R. (1997). Modulation of diclofenac release from a totally soluble controlled release drug delivery system. J Control Release, 44:135-140 (Pubitemid 27039110)
19. Maggi L, Bruni R, Conte U. (2000). High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms. Int J Pharm, 195:229-238
20. Kim C. (1998). Effects on drug solubility, drug loading and polymer molecular weight on drug release from Polyox tablets. Drug Dev Ind Pharm, 24:645-651
21. Ojantakanen S, Marvola M, Hannula A, Klinge E, Naukkarinen T. (1993). Bioavailability of ibuprofen from hard gelatin capsules containing different viscosity grades of hydroxypropylme-thylcellulose and sodium carboxymethylcellulose. Eur J Pharm Sci, 1:109-114
22. Shah A, Britten N, Badalamenti J. (1989). Gel matrix systems exhibiting biomodal controlled release for oral drug delivery. J Control Release, 9:169-175
23. Conte U, Maggi L. (2000). A flexible technology for the linear, pulsatile and delayed release of drugs, allowing for easy accommodation of difficult in vitro targets. J Control Release, 64:263-268
24. Munday L. (1996). Bimodal in vitro release from polymeric matrix tablets containing centralized drug cores. STP Pharm Sci, 6:182-187
25. Conte U, Maggi L, La Manna A. (1994). Compressed barrier layers for constant drug release from swellable matrix tablets. STP Pharm Sci, 4:107-113
26. Korsmeyer R, Gurny R, Doelker E, Buri P, Peppas N. (1983). Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm, 15:25-35.