Beta defensin-1 gene (DEFB1) polymorphisms are not associated with atopic dermatitis in children and adolescents from northeast Brazil (Recife, Pernambuco)

International Journal of Dermatology

Volumn 49, Issue 6, 2010, Pages 653-657

  Segat, Ludovica ^a,b   Guimarães, Rafael L ^a   Brandão, Lucas A C ^a   Rocha, Cintia R C ^a   Zanin, Valentina ^b   Trevisiol, Chiara ^c   de Lima Filho, José Luiz ^a   Crovella, Sergio ^a,b  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^c San Polo Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 1; BETA DEFENSIN; DEFB1 PROTEIN, HUMAN;

5' UNTRANSLATED REGION; ADOLESCENT; ARTICLE; ATOPIC DERMATITIS; BRAZIL; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; DERMATITIS, ATOPIC; GENETIC PREDISPOSITION; GENETICS; INFANT; PRESCHOOL CHILD; RISK FACTOR;

ADOLESCENT; BETA-DEFENSINS; BRAZIL; CHILD; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INFANT; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 77954187079     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/j.1365-4632.2009.04343.x     Document Type: Article

References (20)

1. Kiyohara C, Tanaka K, Miyake Y. Genetic susceptibility to atopic dermatitis. Allergol Int 2008, 57:39-56.
2. Prado-Montes de Oca E, Garcia-Vargas A, Lozano-Inocencio R. Association of beta-defensin 1 single nucleotide polymorphisms with atopic dermatitis. Int Arch Allergy Immunol 2007, 142:211-218.
3. Howell MD. The role of human beta defensins and cathelicidins in atopic dermatitis. Curr Opin Allergy Clin Immunol 2007, 7:413-417.
4. Allaker RP. Host defence peptides-a bridge between the innate and adaptive immune responses. Trans R Soc Trop Med Hyg 2008, 102:3-4.
5. Dork T, Stuhrmann M. Polymorphisms of the human beta-defensin-1 gene. Mol Cell Probes 1998, 12:171-173.
6. Schneider JJ, Unholzer A, Schaller M. Human defensins. J Mol Med 2005, 83:587-595.
7. Yang D, Chertov O, Bykovskaia SN. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell ccr6. Science 1999, 286:525-528.
8. Sun CQ, Arnold R, Fernandez-Golarz C. Human beta-defensin-1, a potential chromosome 8p tumor suppressor: control of transcription and induction of apoptosis in renal cell carcinoma. Cancer Res 2006, 66:8542-8549.
9. Milanese M, Segat L, Crovella S. Transcriptional effect of defb1 gene 5' untranslated region polymorphisms. Cancer Res 2007, 67:5997. Author reply 5997
10. Kim E, Lee JE, Namkung JH. Single nucleotide polymorphisms and the haplotype in the defb1 gene are associated with atopic dermatitis in a Korean population. J Dermatol Sci 2009, 54:25-30.
11. Hanifin JM, Rajka RG. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980, 92:44-47.
12. Severity scoring of atopic dermatitis: the scorad index. Consensus report of the European task force on atopic dermatitis. Dermatology 1993, 186:23-31.
13. Braida L, Boniotto M, Pontillo A. A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with hiv-1 infection in Italian children. AIDS 2004, 18:1598-1600.
14. Jurevic RJ, Bai M, Chadwick RB. Single-nucleotide polymorphisms (SNPS) in human beta-defensin 1: high-throughput SNP assays and association with candida carriage in type i diabetics and nondiabetic controls. J Clin Microbiol 2003, 41:90-96.
15. O'Regan GM, Irvine AD. The role of filaggrin loss-of-function mutations in atopic dermatitis. Curr Opin Allergy Clin Immunol 2008, 8:406-410.
16. Alves-Silva J, da Silva Santos M, Guimaraes PE. The ancestry of brazilian mtDNA lineages. Am J Hum Genet 2000, 67:444-461.
17. Instituto Nacional de Estadística Geografía e Informática (INEGI), XII Censo General de Población y Vivienda 2000
18. Cerda-Flores RM, Villalobos-Torres MC, Barrera-Saldana HA. Genetic admixture in three mexican mestizo populations based on d1s80 and hla-dqa1 loci. Am J Hum Biol 2002, 14:257-263.
19. Dhaliwal W, Kelly P, Bajaj-Elliott M. Differential effects of Staphylococcal enterotoxin B-mediated immune activation on intestinal defensins. Clin Exp Immunol 2009, 156:263-270.
20. Chakraborty K, Ghosh S, Koley H. Bacterial exotoxins downregulate cathelicidin (hCAP-18/LL-37) and human beta-defensin 1 (HBD-1) expression in the intestinal epithelial cells. Cell Microbiol 2008, 10:2520-2537.