The baby who was depressed at birth

Neonatal Cerebral Investigation

Volumn , Issue , 2008, Pages 130-172

  Rennie, Janet M ^a   Hagmann, Cornelia F ^a   Robertson, Nicola J ^a  

^a UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77954174236     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511544750.010     Document Type: Chapter

References (221)

1. Armstrong L, Stenson B. Effect of delayed sampling on umbilical cord arterial and venous lactate and blood gases in clamped and unclamped vessels. Arch Dis Child Fetal Neonatal Ed 2006; 91(5): 342-5.
2. Yeomans ER, Hauth JC, Gilstrap LC, Strickland DM. Umbilical cord pH, PCO2, and bicarbonate following uncomplicated term vaginal deliveries. Am J Obstet Gynecol 1985; 151: 798-800.
3. Boylan PC. In Creasy RK et al. (eds) Maternal-Fetal Medicine. Philadelphia, Saunders, 1999.
4. Eskes TKAB, Jongsma HW, Houx PCW. Percentiles for gas values in human umbilical cord blood. European J Obstet Gynaecol Reprod Med 1983; 14: 341-6.
5. Nelson KB, Dambrosia JM, Ting TY, Grether JK. Uncertain value of electronic fetal monitoring in predicting cerebral palsy. N Engl J Med 1996; 334: 613-18.
6. Parer JT, King T. Fetal heart rate monitoring: is it salvageable? Am J Obstet Gynecol 2000; 182: 982-7.
7. Phelan JP, Ahn MO. Perinatal observations in forty-eight neurologically impaired term infants. Am J Obstet Gynecol 1994; 171: 424-31.
8. Schifrin BS. The CTG and the timing and mechanism of fetal neurological injuries. Best Pract Res Clin Obstet Gynaecol 2004; 18(3): 437-56.
9. Grether JK, Nelson KB. Maternal infection and cerebral palsy in infants of normal birth weight. J Am Med Assoc 1997; 278: 207-11.
10. Nelson KB, Dambrosia JM, Grether JK, Phillips TM. Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol 1998; 44: 665-75.
11. Badawi N, Kurinczuk JJ, Keogh JM, Alessandri LM, O'Sullivan F, Burton PR. Intrapartum risk factors for newborn encephalopathy: the Western Australian case-control study. Br Med J 1998; 317: 1554-8.
12. Lieberman E, Eichenwald E, Mathur G, Richardson D, Heffner L, Cohen A. Intrapartum fever and unexplained seizures in term infants. Pediatrics 2000; 106: 983-8.
13. Impey L, Greenwood C, MacQuillan K, Reynolds M, Sheiel O. Fever in labour and neonatal encephalopathy: a prospective cohort study. Br J Obstet Gynaecol 2001; 108: 594-7.
14. Eklind S, Mallard C, Leverin A-L et al. Bacterial endotoxin sensitizes the imature brain to hypoxic-ischaemic injury. Eur J Neurosci 2001; 13: 1101-6.
15. Tomimatsu T, Fukuda H, Kanagawa T, Mu J, Kanzaki T, Murata Y. Effects of hyperthermia on hypoxic ischaemic brain damage in the immature rat: its influence on caspase-3-like protease. Am J Obstet Gynaecol 2003; 188(3): 768-73.
16. Spellacy WN, Gravem H, Fisch RO. The umbical cord complications of true knots, nuchal coils, and cords around the body. Am J Obstet Gynecol 1966; 94: 1136-42.
17. Thompson CM, Puterman AS, Linley LL et al. The value of a scoring system for hypoxic ischemic encephalopathy in predicting neurodevelopmental outcome. Acta Paediatr Scand 1997; 86: 757-61.
18. Mercuri E, Guzzetta A, Haataja L et al. Neonatal neurological examination in infants with hypoxic ischaemic encephalopathy: correlation with MRI findings. Neuropediatrics 1999; 30: 83-9.
19. Williams CE, Gunn AJ, Mallard C, Gluckman PD. Outcome after ischemia in the developing sheep brain: an electroencephalographic and histological study. Ann Neurol 1992; 31: 14-21.
20. Filan P, Boylan GB, Chorley G et al. The relationship between the onset of electrographic seizure activity after birth and the time of cerebral injury in utero. Br J Obstet Gynaecol 2005; 112: 504-7.
21. van Rooij LGM, Toet MC, Osredkar D, van Huffelen AC, Groenendaal F, de Vries LS. Recovery of amplitude integrated electroencephalographic background patterns within 24 hours of perinatal asphyxia. Arch Dis Child 2005; 90(3): F245-F251.
22. Staudt F, Scholl ML, Coen RW, Bickford RB. Phenobarbital therapy in neonatal seizures and the prognostic value of the EEG. Neuropediatrics 1982; 13: 24-33.
23. Leijser LM, de Vries LS, Cowan FM. Using cerebral ultrasound effectively in the newborn infant. Early Hum Dev 2006; 82(12): 827-35.
24. Archer N, Levene MI, Evans DH. Cerebral artery doppler ultrasound for prediction of outcome after perinatal asphyxia. Lancet 1986; ii: 1116-18.
25. Levene MI, Fenton A, Evans DH, Archer N, Shortland D, Gibson NA. Severe birth asphyxia and abnormal cerebral blood flow velocity. Dev Med Child Neurol 1989; 31: 427-34.
26. Eken P, Toet MC, Groenendaal F, de Vries LS. Predictive value of early neuroimaging, pulsed doppler and neurophysiology in full term infants with hypoxic ischaemic encephalopathy. Arch Dis Child 1995; 73: F75-F81.
27. Barkovich AJ, Hajnal BL, Vigneron D et al. Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems. Am J Neuroradiol 1998; 19: 143-9.
28. Cowan F. Outcome after intrapartum asphyxia in term infants. Semin Neonatol 2000; 5(2): 127-40.
29. Ment LR, Bada HS, Barnes P et al. Practice parameter: neuroimaging of the neonate. Report of the quality standards subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 2002; 58: 1726-38.
30. Miller SP, Ramaswamy V, Michelson D et al. Patterns of brain injury in term neonatal encephalopathy. J Paediatr 2005; 146: 453-60.
31. Sie LTL, van der Knaap MS, Oosting J, de Vries LS, Lafeber HN, Valk J. MR patterns of hypoxic-ischemic brain damage after prenatal, perinatal or postnatal asphyxia. Neuropediatrics 2000; 31: 128-36.
32. Leviton A, Nelson KB. Problems with definitions and classifications of newborn encephalopathy. Pediatr Neurol 1992; 8: 85-90.
33. Marlow N, Budge H. Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy. Arch Dis Child 2005; 90(3): 193-4.
34. Evans K, Rigby AS, Hamilton P, Titchiner N, Hall DMB. The relationships between neonatal encephalopathy and cerebral palsy: a cohort study. J Obstet Gynaecol 2001; 21(2): 114-20.
35. Levene MI, Kornberg J, Williams THC. The incidence and severity of post-asphyxial encephalopathy in full term infants. Early Hum Dev 1985; 11: 21-6.
36. Adamson SJ, Alessandri LM, Badawi N, Burton PR, Pemburton PJ, Stanley F. Predictors of neonatal encephalopathy in full term infants. Br Med J 1995; 311: 598-602.
37. Hull J, Dodd KL. Falling incidence of hypoxic ischaemic encephalopathy in term infants. Br J Obstet Gynaecol 1992; 99: 386-91.
38. Pierrat V, Haouari N, Liska A, Thomas D, Subtil D, Truffert P. Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy: population based study. Arch Dis Child 2005; 90(3): 257-61.
39. Ellis M, Manandhar N, Manandhar DS, de L Costello AM. Risk factors for neonatal encephalopathy in Kathmandu, Nepal, a developing country: unmatched case-control study. Br Med J 2000; 320: 1229-36.
40. Badawi N, Kurinczuk JJ, Keogh JM et al. Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study. Br Med J 1998; 317: 1549-53.
41. Badawi N, Kurinczuk JJ, Mackenzie CL et al. Maternal thyroid disease: a risk factor for newborn encephalopathy in term infants. Br J Obstet Gynaecol 2000; 107: 798-801.
42. Stanley F, Blair E. Cerebral Palsy - Epidemiology and Causal Pathways, 1st edn. Cambridge: MacKeith Press; 2000.
43. Himmelmann K, Hagberg G, Beckung E, Hagberg B, Uvebrant P. The changing panorama of cerebral palsy in Sweden. ix. Prevalence and origin in the birth-year period 1995-1998. Acta Paediatr 2005; 94: 287-94.
44. Hagberg B, Hagberg G, Beckung E, Uvebrant P. Changing panorama of cerebral palsy in Sweden. viii. Prevalence and origin in the birth year period 1991-1994. Acta Paediatr 2001; 90: 271-7.
45. Himmelmann K, Hagberg G, Wiklund LM, Eek MN, Uvebrant P. Dyskinetic cerebral palsy: a population-based study of children born between 1993 and 1998. Dev Med Child Neurol 2007; 49: 246-51.
46. Cowan F, Rutherford M, Groenendaal F et al. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet 2003; 361: 736-42.
47. Myers RE. Two patterns of perinatal brain damage and their conditions of occurrence. Am J Obstet Gynecol 1972; 112: 246-76.
48. Gluckman PD. When and why do brain cells die? Dev Med Child Neurol 1992; 34: 1010-21.
49. Lorek A, Takei Y, Cady EB et al. Delayed ('secondary') cerebral energy failure after acute hypoxia-ischaemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res 1994; 36: 699-706.
50. Derrick M, Drobyshevsky A, Ji X, Tan S. A model of cerebral palsy from fetal hypoxia-ischemia. Stroke 2007; 38: 731-5.
51. Westgate JA, Bennet L, Gunn AJ. Intrapartum hypoxic-ischaemic brain injury. In: Donn SM, Sinha SK, Chiswick ML, eds. Birth Asphyxia and the Brain: Basic Science and Clinical Implications. NewYork, Futura, 2002; 243-79.
52. Johnston MV, Trescher WH, Ishida A, Nakajima W. Neurobiology of hypoxic-ischaemic injury in the developing brain. Pediatr Res 2001; 49: 735-41.
53. Mallard EC, Williams CE, Gunn AJ, Gunning MI, Gluckman PD. Frequent episodes of brief ischemia sensitize the fetal sheep brain to neuronal loss and induce striatal injury. Pediatr Res 1993; 33: 61-5.
54. Mallard EC, Williams CE, Johnston BM, Gunning MI, Davis S, Gluckman PD. Repeated episodes of umbilical cord occlusion in fetal sheep lead to preferential damage to the striatum and sensitize the heart to further insults. Pediatr Res 1995; 37: 707-13.
55. Mallard EC, Waldvogel HJ, Williams CE, Faull RLM, Gluckman PD. Repeated asphyxia causes loss of striatal projection neurons in the fetal sheep brain. Neuroscience 1995; 65: 827-36.
56. Thoresen M, Wyatt J. Keeping a cool head, post-hypoxic hypothermia - an old idea revisited. Acta Paediatr 1997; 86: 1029-33.
57. Iwata O, Iwata S, Thornton JS et al. "Therapeutic time window" duration decreases with increasing severity of cerebral hypoxiaischaemia under normothermia and delayed hypothermia in newborn piglets. Brain Res 2007; 1154: 173-80.
58. Gluckman PD, Wyatt JS, Azzopardi D et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005; 365: 663-70.
59. Myers RE. Four patterns of perinatal brain damage and their occurrence in primates. Adv Neurol 1975; 10: 223-4.
60. Roland EH, Poskitt K, Rodriguez E, Lupton BA, Hill A. Perinatal hypoxic-ischemic thalamic injury: clinical features and neuroimaging. Ann Neurol 1998; 44: 161-6.
61. Pasternak JF, Gorey MT. The syndrome of acute near-total intrauterine asphyxia in the term infant. Pediatr Neurol 1998; 18: 391-8.
62. Okumura A, Hayakawa F, Kato T, Kuno K, Watanabe K. Bilateral basal ganglia-thalamic lesions subsequent to prolonged fetal bradycardia. Early Hum Dev 2000; 58: 111-18.
63. Natsume J, Watanabe K, Kuno K, Hayakawa F, Hashizume Y. Clinical, neurophysiologic, and neuropathological features of an infant with brain damage of total asphyxia type (Myers). Pediatr Neurol 1995; 13: 61-4.
64. Krageloh-Mann I, Helber A, Mader I et al. Bilateral lesions of thalamus and basal ganglia: origin and outcome. Dev Med Child Neurol 2002; 44: 477-84.
65. Naeye RL, Lin H-M. Determination of the timing of fetal brain damage from hypoxemia-ischaemia. Am J Obstet Gynecol 2001; 184: 217-24.
66. Bennet L, Westgate JA, Gluckman PD, Gunn AJ. Pathophysiology of asphyxia. In: Levene MI, Chervenak FA, Whittle M, eds. Fetal and Neonatal Neurology and Neurosurgery, 3rd edn. London, Churchill Livingstone, 2001; 407-26.
67. Bobrow CS, Soothill P. Causes and consequences of fetal acidosis. Arch Dis Child 1999; 80: F246-F249.
68. Brann AW, Myers RE. Central nervous system findings in the newborn monkey following severe in utero partial asphyxia. Neurology 1975; 25: 327-38.
69. Ikeda T, Murata Y, Quilligan EJ et al. Physiologic and histologic changes in near-term fetal lambs exposed to asphyxia by partial umbilical cord occlusion. Am J Obstet Gynecol 1998; 178: 24-32.
70. Gunn AJ, Parer JT, Mallard EC, Williams CE, Gluckman PD. Cerebral histologic and electrophysiologic changes after asphyxia in fetal sheep. Pediatr Res 1992; 31: 486-91.
71. De Haan HH, Gunn AJ, Williams CE, Gluckman PD. Brief repeated umbilical cord occlusions cause sustained cytotoxic cerebral edema and focal infarcts in near-term fetal lambs. Pediatr Res 1997; 41: 96-104.
72. Ball RH, Parer JT, Caldwell LE, Johnson J. Regional blood flow and metabolism in ovine fetuses during severe cord occlusion. Am J Obstet Gynecol 1994; 171: 1549-55.
73. Connolly DJA, Widjaja E, Griffiths PD. Involvement of the anterior lobe of the cerebellar vermis in perinatal profound hypoxia. Am J Neuroradiol 2007; 28(1): 16-19.
74. Sargent MA, Poskitt KJ, Roland EH, Hill A, Hendson G. Cerebellar vermian atrophy after neonatal hypoxic ischaemic encephalopathy. Am J Neuroradiol 2004; 25: 1008-15.
75. McDonald JW, Johnston MV. Physiological and pathophysiological roles of excitatory amino acids during CNS development. Brain Res 1990; 15: 41-70.
76. Brown GC, Bal-Price A. Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Mol Neurobiol 2003; 27: 325-55.
77. Northington FJ, Ferriero DM, Graham EM, Traystman RJ, Martin LJ. Early neurodegeneration after hypoxic ischemia in neonatal rat is necrosis while delayed neuronal death is apoptosis. Neurobiol Dis 2001; 8(2): 201-19.
78. Orrenius S, Zhivotovsky B, Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nature Rev Mol Cell Biol 2003; 4(7): 552-65.
79. Taylor DL, Edwards AD, Mehmet H. Oxidative metabolism, apoptosis and perinatal brain injury. Brain Pathol 1999; 9(1): 93-117.
80. Volpe JJ, Pasternak JF. Parasagittal cerebral injury in neonatal hypoxicischaemic encephalopathy. J Pediatr 1977; 91: 472-6.
81. Williams CE, Gunn AJ, Mallard C, Gluckman PD. Outcome after ischemia in the developing sheep brain: an electroencephalographic and histological study. Ann Neurol 1992; 31(1): 14-21.
82. Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. Arch Neurol 1976; 33: 696-705.
83. Levene MI, Sands C, Grindulis H, Moore JR. Comparison of two methods of predicting outcome in perinatal asphyxia. Lancet 1986; i: 67-8.
84. Miller SP, Latal B, Clark H et al. Clinical signs predict 30-month neurodevelopmental outcome after neonatal encephalopathy. Am J Obstet Gynaecol 2004; 190: 93-9.
85. Robertson CMT, Finer NN. Long term follow up of term neonates with birth asphyxia. Clin Perinatol 1993; 20: 483-500.
86. Rosenbloom L. Dyskinetic cerebral palsy and birth asphyxia. Dev Med Child Neurol 1994; 36: 285-9.
87. Perlman JM, Tack ED. Renal injury in the asphyxiated newborn: relationship to neurologic outcome. J Pediatr 1988; 113: 875-9.
88. Shah P, Riphagen S, Beyene J, Perlman M. Multiorgan dysfunction in infants with post-asphyxial hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatol Ed 2004; 89: F152-F155.
89. Williams CE, Gunn AJ, Synek B, Gluckman PD. Delayed seizures occurring with hypoxic-ischemic encephalopathy in the fetal sheep. Pediatr Res 1990; 27(6): 561-5.
90. Williams CE, Gunn A, Gluckman PD. Time course of intracellular oedema and epileptiform activity following prenatal cerebral ischaemia in sheep. Stroke 1991; 22: 516-21.
91. McBride MC, Laroia N, Guillet R. Electrographic seizures in neonates correlate with poor neurodevelopmental outcome. Neurology 2000; 55: 506-13.
92. Bye AME, Cunningham CA, Chee KY, Flanagan D. Outcome of neonates with electro-graphically identified seizures, or at risk of seizures. Pediatr Neurol 1997; 16: 225-31.
93. Pressler RM, Boylan GB, Morton M, Binnie CD, Rennie JM. Early serial EEG in hypoxic ischaemic encephalopathy. Clin Neurophysiol 2001; 112: 31-7.
94. Selton D, Andre M. Prognosis of hypoxic-ischaemic encephalopathy in full-term newborns - value of neonatal electroencephalography. Neuropediatrics 1997; 28: 276-80.
95. Harris R, Tizard JPM. EEG in neonatal convulsions. J Pediatr 1960; 57: 510-14.
96. Rose A, Lombroso CT. Neonatal seizure states: a study of clinical, pathological, and electroencephalographic features in 137 full-term babies with a long-term follow-up. Pediatrics 1970; 45: 404-25.
97. van Lieshout HBM, Jacobs JFM, Rotteveel JJ, Geven W, von dort Hoeffmann M. The prognostic value of the EEG in asphyxiated newborns. Acta Neurol Scand 1995; 91: 203-7.
98. Takeuchi T, Watanabe K. The EEG evolution and neurological prognosis of perinatal hypoxia neonates. Brain Dev 1989; 11: 115-20.
99. Watanabe K, Miyazaki S, Hara K, Hakamanda A. Behavioral state cycles, background EEGs and prognosis of newborn with perinatal hypoxia. Electroencephalogr Clin Neurophysiol 1980; 49: 618-25.
100. Wertheim D, Mercuri E, Faundez JC, Rutherford M, Acolet D, Dubowitz L. Prognostic value of continuous electroencephalographic recording in full term infants with hypoxic ischaemic encephalopathy. Arch Dis Child 1994; 71: F97-F102.
101. de Vries LS, Hellstrom-Westas L. Role of cerebral function monitoring in the newborn. Arch Dis Child 2005; 90(3): 201-7.
102. Holmes GL, Lombroso CT. Prognostic value of background patterns in the neonatal EEG. J Clin Neurophysiol 1993; 10(3): 323-52.
103. Aso K, Scher MS, Barmada MA. Neonatal electroencephalography and neuropathology. J Clin Neurophysiol 1989; 6: 103-23.
104. Monod N, Pajot N, Guidasci S. The neonatal EEG: statistical studies and prognostic value in full term and preterm babies. Electroencephalogr Clin Neurophysiol 1972; 32: 529-44.
105. Holmes G, Rowe J, Schmidt R, Testa M, Zimmerman A. Prognostic value of the electroencephalogram in neonatal seizures. Electroencephalogr Clin Neurophysiol 1982; 53: 60-72.
106. Pezzani C, Radvani-Bouvet MF, Relier JP, Monod N. Neonatal electroencephalography during the first 24 hours of life in full term newborn infants. Neuropediatrics 1986; 17: 11-18.
107. Grigg-Damberger MM, Coker SB, Halsey CL, Anderson CL. Neonatal burst supression: its developmental significance. Pediatr Neurol 1989; 5: 84-92.
108. Peliowski A, Finer NN. Asphyxia in the term infant. In: Sinclair JC, Bracken MB, eds. Effective Care of the Newborn Infant 1st edn. Oxford, Oxford University Press, 1992; 249-79.
109. Tharp BR. Neonatal seizures and syndromes. Epilepsia 2002; 43(3): 2-10.
110. Biagioni E, Mercuri E, Rutherford M et al. Combined use of electroencephalogram and magnetic resonance imaging in full-term neonates with acute encephalopathy. Pediatrics 2001; 107: 461-8.
111. al Naqeeb N, Edwards AD, Cowan F, Azzopardi D. Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography. Pediatrics 1999; 103: 1263-71.
112. Toet MC, van der Meij W, de Vries LS, Uiterwaal CPM, van Huffelen KC. Comparison between simultaneously recorded amplitude integrated electroencephalogram (cerebral function monitor) and standard electrocephalogram in neonates. Pediatrics 2002; 109: 772-9.
113. Hellström-Westas L, Rosen I, Svenningsen NW. Predictive value of early continuous amplitude integrated EEG recordings on outcome after severe birth asphyxia in full term infants. Arch Dis Child 1995; 72: F34-F38.
114. Toet MG, Hellstrom-Westas L, Groenendaal F, Eken P, de Vries LS. Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy. Arch Dis Child 1999; 81: F19-F23.
115. Thornberg E, Ekstrom-Jodal B. Cerebral function monitoring: a method of predicting outcome in term neonates after severe perinatal asphyxia. Acta Paediatr Scand 1994; 83: 596-601.
116. Ter Horst HJ, Sommer C, Bergman KA, Fock JM, Van Weerden TW, Bos AF. Prognostic significance of amplitude-integrated EEG during the first 72 hours after birth in severely asphyxiated neonates. Pediatr Res 2004; 55: 1026-33.
117. Toet MC, Lemmers PMA, van Schelven LJ, Van Bel F. Cerebral oxygenation and electrical activity after birth asphyxia: their relation to outcome. Pediatrics 2006; 17(2): 333-9.
118. van Rooij LG, Toet MC, Osredkar D, Van Heffelen AC, Groenendaal F, de Vries LS. Recovery of amplitude integrated electroencephalographic background patterns within 24 hours of perinatal asphyxia. Arch Dis Child Fetal Neonatal Ed 2005; 90(3): F245-51.
119. Ter Horst HJ, Brouwer OF, Bos AF. Burst suppression on amplitudeintegrated electroencephalogram may be induced by midazolam: a report on three cases. Actra Paediatr Scand 2004; 93: 559-64.
120. Verma UL, Archbald F, Tejani NA, Handwerker SM. Cerebral function monitor in the neonate. I: normal patterns. Dev Med Child Neurol 1984; 26: 154-61.
121. Osredkar D, Toet MC, van Rooji LGM, van Huffelen AC, Groenendaal F, de Vries L. Sleep-wake cycling on amplitude-integrated electroencephalography in term newborns with hypoxic-ischemic encephalopathy. Pediatrics 2005; 115(2): 327-32.
122. Hagmann CF, Robertson NJ, Azzopardi D. Artifacts on electroencephalograms may influence the amplitude-integrated EEG classification: a qualitiative analysis in neonatal encephalopathy. Pediatr Experience Reason 2006; 118(6): 2552-4.
123. Hellström-Westas L, Rosen I, de Vries LS, Greisen G. Amplitudeintegrated EEG classification and interpretation in preterm and term infants. Neoreviews 2006; 7(2): E76-E87.
124. Sheehy-Skeffington F, Pearce RG. The "bright brain". Arch Dis Child 1983; 58: 509-11.
125. Shen E-Y, Hunag CC, Chyou SC, Hung HY, Hsu CH, Hunag FY. Sonographic findings of the bright thalamus. Arch Dis Child 1986; 61: 1096-9.
126. Voit T, Lemburg P, Neve E, Lumenta C, Stork W. Damage of thalamus and basal ganglia in asphyxiated full term neonates. Neuropediatrics 1987; 18: 176-81.
127. Connolly B, Kelehan P, O'Brien NO et al. The echogenic thalamus in hypoxic-ischaemic encephalopathy. Pediatr Radiol 1994; 24: 268-71.
128. Rutherford MA, Pennock JM, Dubowitz LMS. Cranial ultrasound and magnetic resonance imaging in hypoxic ischaemic encephalopathy: a comparison with outcome. Dev Med Child Neurol 1994; 36: 813-25.
129. Leijser LM, Cowan FM. State-of-the-art neonatal cranial ultrasound. Ultrasound 2007; 15(1): 6-17.
130. Eken P, Jansen GH, Groenendaal F, Rademaker KJ, de Vries LS. Intracranial lesions in the fullterm infant with hypoxic ischaemic encephalopathy: ultrasound and autopsy correlation. Neuropediatrics 1994; 25: 301-7.
131. Siegel MJ, Shackleford GD, Perlman JM, Fulling KH. Hypoxic ischaemic encephalopathy in term infants: diagnosis and prognosis evaluated by ultrasound. Radiology 1984; 152: 395-9.
132. Galli KK, Zimmerman RA, Jarvik GP et al. Periventricular leukomalacia is common after neonatal cardiac surgery. J Thorac Cardiovasc Surg 2004; 127: 692-704.
133. McQuillen PS, Barkovich AJ, Hamrick SEG et al. Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects. Stroke 2007; 38: 736-41.
134. Van Bel F, Van de Bor M, Stijnen T, Baan J, Ruys JH. Cerebral blood flow velocity patterns in healthy and asphyxiated newborns: a controlled study. Eur J Pediatr 1987; 146: 461-57.
135. Rennie JM, South M, Morley CJ. Cerebral blood flow velocity variability in infants receiving assisted ventilation. Arch Dis Child 1987; 62: 1247-51.
136. Boylan G, Young K, Panerai RB, Rennie JM, Evans DH. Dynamic cerebral autoregulation in sick newborn infants. Pediatr Res 2000; 48: 12-17.
137. McMenamin JB, Volpe JJ. Doppler ultrasonography in the determination of neonatal brain death. Arch Neurol 1983; 14: 302-6.
138. Glasier CM, Seibert JJ, Chadduck WM, Williamson SL, Leithiser RE. Brain death in infants: evaluation with Doppler US. Radiology 1989; 172: 377-80.
139. Hassler W, Steinmetz H, Gawlowski J. Transcranial doppler ultrasonography in raised ICP and in intracranial circulatory arrest. J Neurosurg 1988; 68: 745-51.
140. Kirkham FJ, Levin SD, Padayachee TS, Kyme MC, Neville BGR, Gosling RG. Transcranial pulsed Doppler findings in brain stem death. J Neurol Neurosurg Psychiatry 1987; 50: 1504-13.
141. Barkovich AJ, Truwit CL. Brain damage from perinatal asphyxia: correlation of MR findings with gestational age. Am J Neuroradiol 1990; 11: 1087-96.
142. Barkovich AJ. MR and CT evaluation of profound neonatal and infantile asphyxia. Am J Neuroradiol 1992; 13: 959-72.
143. Barkovich AJ, Westmark K, Partridge A, Sola A, Ferriero DM. Perinatal asphyxia: MR findings in the first 10 days. Am J Neuroradiol 1995; 16: 427-38.
144. Baenziger O, Martin E, Steinlin M et al. Early pattern recognition in severe perinatal asphyxia; a prospective MR study. Neuroradiology 1993; 35: 437-42.
145. Kuenzle CL, Baenziger O, Martin E et al. Prognostic value of early MR imaging in term infants with severe perinatal asphyxia. Neuropediatrics 1994; 25: 191-200.
146. Byrne P, Welch R, Johnson MA, Darrah J, Piper M. Serial magnetic resonance imaging in neonatal hypoxic ischaemic encephalopathy. J Pediatr 1990; 117: 694-700.
147. Truwit CL, Barkovich AJ, Koch TK, Ferriero DM. Cerebral palsy: MRI findings. Am J Neuroradiol 1992; 13: 67-78.
148. Steinlin M, Dirr R, Martin E et al. MRI following severe perinatal asphyxia: preliminary experience. Pediatr Neurol 1991; 7: 164-70.
149. Keeney SE, Adcock EW, McArdle CB. Prospective observations of 100 high-risk neonates in high field (1.5 tesla) magnetic resonance imaging of the central nervous system. II. Lesions associated with hypoxic-ischemic encephalopathy. Pediatrics 1991; 87: 431-8.
150. Rutherford MA, Pennock JM, Schweiso JE, Cowan FM, Dubowitz LMS. Hypoxic ischaemic encephalopathy: early magnetic resonance image findings and their evolution. Neuropediatrics 1995; 26: 183-91.
151. Rutherford M, Pennock J, Schwieso J, Cowan F, Dubowitz L. Hypoxicischaemic encephalopathy: early and late magnetic resonance imaging findings in relation to outcome. Arch Dis Child 1996; 75: F145-F151.
152. Barkovich AJ, Miller SP, Bartha A et al. MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. Am J Neuroradiol 2006; 27: 533-47.
153. Rutherford M. Neuroimaging of hypoxic-ischaemic encephalopathy. In: Donn SM, Sinha SK, Chiswick ML, eds. Birth Asphyxia and the Brain: Basic Science and Clinical Implications. New York, Futura, 2002; 315-54.
154. Rutherford MA. The asphyxiated term infant. In: Rutherford MA, ed. MRI of the Neonatal Brain, 1st edn. London, W.B.Saunders, 2002; 99-128.
155. Jouvet P, Cowan FM, Cox P et al. Reproducibility and accuracy of MR imaging of the brain after severe birth asphyxia. Ame J Neuroradiol 1999; 20: 1343-8.
156. Robertson NJ, Wyatt JS. The magnetic resonance revolution in brain imaging: impact on neonatal intensive care. Arch Dis Child 2004; 89(3): 193-7.
157. Barkovich AJ. MR imaging of the neonatal brain. Neuroimag Clin North Am 2006; 16: 117-35.
158. Frigieri G, Guidi B, Zaccarelli SC et al. Multicystic encephalomalacia in term infants. Child Nerv Syst 1996; 12: 759-64.
159. Weidenheim KM, Bodhireddy SR, Nuovo GJ, Nelson SJ, Dickson DW. Multicystic encephalopathy: revivew of eight cases with etiologic considerations. J Neuropathol Exp Neurol 1995; 54: 268-75.
160. Rademakers RP, van der Knaap MS, Verbeeten B, Barth PG, Valk J. Central cortico-subcortical involvement. a distinct pattern of brain damage caused by perinatal and postnatal asphyxia in term infants. J Comput Assist Tomogr 1995; 19: 256-63.
161. Barkovich AJ, Sargent SK. Profound asphyxia in the premature infant: imaging findings. Am J Neuroradiol 1995; 16: 1837-46.
162. Marlow N, Rose AS, Rands CE, Draper ES. Neuropsychological and educational problems at school age associated with neonatal encephalopathy. Arch Dis Child 2005; 90(5): 380-7.
163. Barnett A, Mercuri E, Rutherford M et al. Neurological and perceptual-motor outcomes at 5-6 years of age in children wtih neonatal encephalopathy: relationship with neonatal MRI. Neuropaediatrics 2002; 33: 242-8.
164. Childs A-M, Cornette L, Ramenghi LA et al. Magnetic resonance and cranial ultrasound characteristics of periventricular white matter abnormalities in newborn infants. Clin Radiol 2001; 56: 647-55.
165. Konishi Y, Kuriyama M, Hayakawa K et al. Periventricular hyperintensity detected by magnetic resonance imaging in Infancy. Pediatr Neurol 1990; 6: 229-32.
166. Muir KW, Buchan A, von Kummer R, Rother J, Baron JC. Imaging of acute stroke. Lancet Neurol 2006; 5(9): 755-68.
167. Barkovich AJ, Westmark KD, Bedi HS, Partridge JC, Ferriero DM, Vigneron DB. Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia: preliminary report. Am J Neuroradiol 2001; 22: 1786-94.
168. Thornton JS, Ordridge RJ, Penrice J et al. Temporal and anatomical variations of brain water apparent diffusion coefficient in perinatal cerebral hypoxic-ischemic injury: relationships to cerebral energy metabolism. Magn Reson Med 1998; 39(6): 920-7.
169. Neumann-Haefelin T, Kastrup A, de Crespigny MA, Yenari T, Ringer GH. Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation. Stroke 2000; 31: 1311-17.
170. Soul JS, Robertson RL, Tzika AA, du Plessis AJ, Volpe JJ. Time course of changes in diffusion-weighted magnetic resonance imaging in a case of neonatal encephalopathy with defined onset and duration of hypoxic-ischemic insult. Paediatrics 2001; 108: 1211-14.
171. Neil JJ, Shiran SI, McKinstry RC et al. Normal brain in human newborns: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MR imaging. Radiology 1998; 209(1): 57-66.
172. Zarifi MK, Astrakas LG, Poussaint TY, Plessis AA, Zurakowski D, Tzika AA. Prediction of adverse outcome with cerebral lactate level and apparent diffusion coefficient in infants with perinatal asphyxia. Radiology 2002; 225(3): 859-70.
173. McKinstry RC, Miller JH, Snyder AZ et al. A prospective, longitudinal diffusion tensor imaging study of brain injury in newborns. Neurology 2002; 59: 824-33.
174. Robertson RL, Ben-Sira L, Barnes PD et al. MR line-scan diffusionweighted imaging of term neonates with perinatal brain ischemia. Am J Neuroradiol 1999; 20: 1658-70.
175. Forbes KPN, Pipe JG, Bird R. Neonatal hypoxic-ischemic encephalopathy: detection with diffusion-weighted MR imaging. Am J Neuroradiol 2000; 21: 1490-6.
176. Hunt RW, Neil JJ, Coleman LT, Kean MJ, Inder TE. Apparent diffusion coefficient in the posterior limb of the internal capsule predicts outcome after perinatal asphyxia. Pediatrics 2004; 114(4): 999-1003.
177. Rutherford M, Counsell S, Allsop J et al. Diffusion-weighted magnetic resonance imaging in term perinatal brain injury: a comparison with site of lesion and time from birth. Pediatrics 2004; 114(4): 1004-14.
178. Ward P, Counsell S, Allsop J et al. Reduced fractional anisotropy on diffusion tensor magnetic resonance imaging after hypoxic-ischemic encephalopathy. Pediatrics 2006; 117(4): E619-E630.
179. Shanmugalingam S, Thornton JS, Iwata O et al. Comparative prognostic utilities of early quantitative magnetic resonance imaging spin-spin relaxometry and proton magnetic resonance spectroscopy in neonatal encephalopathy. Pediatrics 2006; 118(4): 1467-77.
180. Martin LJ, Al-Abdulla NA, Brambrink AM, Kirsch JR, Sieber FE, Portera-Cailliau C. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis. Brain Res Bull 1998; 46(4): 281-309.
181. Pouwels PJ, Brockmann K, Kruse B et al. Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS. Pediatr Res 1999; 46(4): 474-85.
182. Cady EB, Costello A, Dawson MJ et al. Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy. Lancet 1983; 1: 1059-62.
183. Hope PL, Costello AMDL, Cady EB et al. Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphxiated infants. Lancet 1984; ii: 366-9.
184. Younkin D, Delivoria-Papadopoulos M. Unique aspects of human cerebral metabolism evaluated with P31-NMR. Ann Neurol 1984; 16: 581-6.
185. Laptook AR, Corbett RJ, Uauy R, Mize C, Mendelsohn D, Nunally RL. Use of 31-P NMRS to characterise existing brain damage after neonatal asphyxia. Neurology 1989; 39: 709-12.
186. Martin E, Buchli R, Ritter S et al. Diagnostic and prognostic value of cerebral 31P magnetic resonance spectroscopy in neonates with perinatal asphyxia. Pediatr Res 1996; 40: 749-58.
187. Azzopardi D, Wyatt JS, Reynolds EOR. Prognosis of newborn infants with hypoxic-ischaemic brain injury assessed by P-NIRS. Pediatr Res 1989; 25: 445-51.
188. Roth SC, Edwards D, Cady EB et al. Relation between cerebral oxidative metabolism following birth asphyxia and neurodevelopmental outcome. Dev Med Child Neurol 1992; 34(4): 285-95.
189. Roth SC, Baudin J, Cady EB et al. Relation of deranged neonatal cerebral oxidative metabolism with neurodevelopmental outcome and head circumference at 4 years. Dev Med Child Neurol 1997; 39: 718-25.
190. Blumberg RM, Cady EB, Wigglesworth JS, McKenzie JE, Edwards AD. Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxiaischaemia in the developing brain. Exp Brain Res 1997; 113(1): 130-7.
191. O'Brien FE, Iwata O, Thornton JS et al. Delayed whole-body cooling to 33 or 35 degrees C and the development of impaired energy generation consequential to transient cerebral hypoxia-ischemia in the newborn piglet. Pediatrics 2006; 117(5): 1549-59.
192. Robertson NJ, Cowan F, Cox IJ, Edwards AD. Brain alkaline intracellular pH after neonatal encephalopathy. Ann Neurol 2002; 52: 732-42.
193. Kendall GS, Robertson NJ, Iwata O, Peebles D, Raivich G. N-Methylisobutyl- amiloride ameliorates brain injury when commenced before hypoxia ischemia in neonatal mice. Pediatr Res 2006; 59(2): 227-31.
194. Lei H, Peeling J. Effect of temperature on the kinetics of lactate production and clearance in a rat model of forebrain ischemia. Biochem Cell Biol 1998; 76: 503-9.
195. Penrice J, Cady EB, Wylezinska M et al. Proton magnetic resonance spectroscopy of the brain in normal preterm and term infants, and early changes after perinatal hypoxia-ischaemia. Pediatr Res 1996; 40: 6-14.
196. Amess PN, Wylezinska M, Lorek A et al. Early brain proton magnetic resonance spectroscopy and neonatal neurology related to neurodevelopmental outcome at 1 year in term infants after presumed hypoxic-ischaemic brain injury. Dev Med Child Neurol 1999; 41: 436-45.
197. Rothman DL, Sibson NR, Hyder F, Shen J, Behar KL, Shulman RG. In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics. Philos Trans R Soc London Biol Sci 1991; 354: 1165-77.
198. Groenendaal F, Veenhoven R, van der Grond J, Jansen GH, Witkamp TD, de Vries LS. Cerebral lactate and N-acetyl aspartate: choline ratios in asphyxiated full term neonates demonstrated in vivo using proton MRS. Pediatr Res 1994; 35: 148-51.
199. Barkovich AJ, Baranski K, Vigneron D et al. Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. Am J Neuroradiol 1999; 20: 1399-405.
200. Robertson NJ, Cox IJ, Cowan FM, Counsell SJ, Azzopardi D, Edwards AD. Cerebral intracellular lactic alkalosis persisting months after neonatal encephalopathy measured by magnetic resonance spectroscopy. Pediatr Res 1999; 46: 287-96.
201. Miller SP, Newton N, Ferriero DM et al. Predictors of 30-month outcome after perinatal depression: role of proton MRS and socioeconomic factors. Pediatr Res 2002; 52(1): 71-7.
202. Cheong JL, Cady EB, Penrice J, Wyatt JS, Cox IJ, Robertson NJ. Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury: metabolite peak-area ratios, relaxation times, and absolute concentrations. Am J Neuroradiol 2006; 27: 1546-54.
203. Shankaran S, Laptook AR, Ehrenkranz RA et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005; 353(15): 1574-84.
204. Azzopardi D, Robertson NJ, Cowan FM, Rutherford MA, Rampling M, Edwards AD. Pilot study of treatment with whole body hypothermia for neonatal encephalopathy. Pediatrics 2000; 106(4): 684-94.
205. Iwata S, Iwata O, Thornton JS et al. Superficial brain is cooler in small piglets: neonatal hypothermia implications. Ann Neurol 2006; 60: 578-85.
206. Haaland K, Loberg EM, Steen PA, Satas S, Thoresen M. The effect of mild post-hypoxic hypothermia on organ pathology in a piglet survival model of global hypoxia. Prenat Neonat 1997; 2: 329-37.
207. Nedelcu J, Klein MA, Aguzzi A, Martin E. Resuscitative hypothermia protects the neonatal rat brain from hypoxic-ischemic injury. Brain Pathol 2000; 10(1): 61-71.
208. Ma D, Hossain M, Chow A et al. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol 2005; 58(2): 182-93.
209. Rutherford MA, Azzopardi D, Whitelaw A et al. Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy. Pediatrics 2005; 116(4): 1001-6.
210. Inder TE, Hunt RW, Morley CJ et al. Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy. J Paediatr 2004; 145: 835-7.
211. Kim Y, Busto R, Dietrich WD, Kraydieh S, Ginsberg MD. Delayed postischemic hyperthermia in awake rats worsens the histopathological outcome of transient focal cerebral ischemia. Stroke 1996; 27(12): 2274-3380.
212. Shevell MI, Majnemer A, Miller SP. Neonatal neurological prognostication: the asphyxiated term newborn. Pediatr Neurol 1999; 21: 776-84.
213. Gray PH, Tudehope DI, Masel JP et al. Perinatal hypoxic ischaemic brain injury: prediction of outcome. Dev Med Child Neurol 1993; 35: 965-73.
214. Rennie JM, Hagmann CF, Robertson NJ. Outcome after intrapartum hypoxic ischaemia at term. Semin Fetal Neonatal Med 2007; 12(5): 398-407.
215. Gonzalez FF, Miller SP. Does perinatal asphyxia impair cognitive function without cerebral palsy? Arch Dis Child Fetal Neonat Ed 2006; 91: 454-9.
216. Mercuri E, Ricci D, Cowan FM et al. Head growth in infants with hypoxic-ischaemic encephalopathy: correlation with neonatal magnetic resonance imaging. Pediatrics 2000; 106: 235-44.
217. De Haan M, Wyatt JS, Roth S, Vargha-Khadem F, Gadian D, Mishkin M. Brain and cognitive-behavioural development after asphyxia at term birth. Dev Sci 2006; 9: 350-8.
218. Gadian DG, Aicardi J, Watkins KE, Porter DA, Mishkin M, Vargha- Khadem F. Developmental amnesia associated with early hypoxicischaemic injury. Brain 2000; 123: 499-507.
219. Khong PL, Lam BCC, Tung HKS, Wong V, Chan FL, Ooi GC. MRI of neonatal encephalopathy. Clin Radiol 2003; 58: 833-44.
220. Cavalleri F, Berardi A, Burlina AB, Ferrari F, Mavilla L. Diffusionweighted MRI of maple syrup urine disease encephalopathy. Neuroradiology 2002; 44(6): 499-502.
221. Khong PL, Lam BC, Chung BH, Wong KY, Ooi GC. Diffusion-weighted MR imaging in neonatal nonketotic hyperglycinemia. Am J Neuroradiol 2003; 24(6): 1181-3.