N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells

Free Radical Biology and Medicine

Volumn 49, Issue 3, 2010, Pages 392-400

  Zahid, Muhammad ^a   Saeed, Muhammad ^a   Ali, Mohammed F ^a   Rogan, Eleanor G ^a   Cavalieri, Ercole L ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Breast epithelial cells; Cancer prevention; Catechol estrogen quinones; Depurinating estrogen DNA adducts; Free radicals; Homeostasis of estrogen metabolism; N acetylcysteine

Indexed keywords

17BETA ESTRADIOL 3,4 QUINONE; 4 HYDROXYESTRADIOL; ACETYLCYSTEINE; ESTROGEN; ESTROGEN RECEPTOR ALPHA; UNCLASSIFIED DRUG; 4-HYDROXYESTRADIOL; ANTIOXIDANT; CATECHOL ESTROGEN; DNA ADDUCT; ESTRADIOL; ESTRADIOL-3,4-QUINONE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL MODIFICATION; CONJUGATION; CONTROLLED STUDY; DNA ADDUCT; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROCHEMISTRY; ESTROGEN METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; METABOLITE; METHOXYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; BREAST; BREAST NEOPLASMS; CELL LINE; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; UDDER;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; BREAST; BREAST NEOPLASMS; CELL LINE; DNA ADDUCTS; ESTRADIOL; ESTROGENS, CATECHOL; FEMALE; HUMANS; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE;

EID: 77954144592     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.04.028     Document Type: Article

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