Genomic analysis of the 55 kDa subunit of DNA polymerase ε in human intracranial neoplasms

Cancer Genomics and Proteomics

Volumn 7, Issue 3, 2010, Pages 143-146

  Zhou, Qi ^a   Lehtonen, Tuomo ^a   Lehtonen, Jaana ^a   Laakso, Susana ^a   Szymas, Janusz ^b   Pospiech, Helmut ^c   Huoponen, Kirsi ^a   Syväoja, Juhani ^d   Collan, Yrjö ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^c UNIVERSITY OF OULU   (Finland)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Astrocytoma; Atypical meningioma; Brain neoplasms; DNA polymerase epsilon ( ); Genomic changes; Glioblastoma; Metastasis

Indexed keywords

DNA DIRECTED DNA POLYMERASE EPSILON; DNA; DNA DIRECTED DNA POLYMERASE ALPHA;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN TUMOR; CANCER RISK; CLINICAL ARTICLE; CONTROLLED STUDY; DNA POL EPSILON GENE; DNA SEQUENCE; FEMALE; GENE; GENE MUTATION; GENOMICS; HUMAN; HUMAN TISSUE; INTRACRANIAL TUMOR; INTRON; MALE; POLAND; SEQUENCE ANALYSIS; ENZYMOLOGY; GENETICS; HUMAN GENOME; NUCLEOTIDE SEQUENCE; PATHOLOGY; POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM;

BASE SEQUENCE; BRAIN NEOPLASMS; DNA POLYMERASE II; DNA, NEOPLASM; GENOME, HUMAN; HUMANS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 77954139443     PISSN: 11096535     EISSN: 17906245     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Syväoja JE and Pospiech H: The elongation phase of the eukaryotic DNA replication. In: DNA Replication, Repair and Recombination at the Crossroad Between Genome Integrity and Genomic Instability: A Biochemical Perspective. Maga G, Hubscher U and Villani G (eds.). Kerala, India: Research Signpost, pp. 21-40, 2008.
2. Pospiech H and Syväoja JE: DNA polymerase ε - More than a polymerase. Sci World J 3: 87-104, 2003.
3. Pospiech H, Kursula I, Abdel-Aziz W, Malkas L, Uitto L, Kastelli M, Vihinen-Ranta M, Eskelinen S and Syväoja JE: A neutralizing antibody against human Pol ε inhibits cellular but not SV40 DNA replication. Nucleic Acids Res 27: 3799-3804, 1999. (Pubitemid 29454427)
4. Waga S, Masuda T, Takisawa H and Sugino A: DNA polymerase ε is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts. Proc Natl Acad Sci USA 98: 4978-4983, 2001. (Pubitemid 32397068)
5. Albertson TM, Ogawa M, Bugni JM, Hays LE, Chen Y, Wang Y, Treuting PM, Heddle JA, Goldsby RE and Preston BD: DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice. Proc Natl Acad Sci USA 106: 17101-17104, 2009.
6. Asturias FJ, Cheung IK, Sabouri N, Chilkova O, Wepplo D and Johansson E: Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy. Nat Struct Mol Biol 13: 35-43, 2006. (Pubitemid 43049400)
7. Sugino A: Yeast DNA polymerases and their role at the replication fork. Trends Biochem Sci 20: 319-323, 1995.
8. Pursell ZF, Isoz I, Lundström E-B, Johansson E and Kunkel TA: Yeast DNA polymerase epsilon participates in leading-strand DNA replication. Science 317: 127-130, 2007. (Pubitemid 47056472)
9. Jaszczur M, Flis K, Rudzka J, Kraszewska J, Budd ME, Polaczek J, Campbell L, Jonczyk P and Fijalkowska IJ: Dpb2p, a noncatalytic subunit of DNA polymerase {varepsilon}, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae. Genetics 178: 633-647, 2008.
10. Araki H, Hamatake RK, Johnston LH and Sugino A: dpb2, the gene encoding DNA polymerase II subunit B, is required for chromosomal replication in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 88: 4601-4605, 1991. (Pubitemid 21914589)
11. Kesti T, McDonald WH, YatesIII JR and Wittenberg C: Cell cycle-dependent phosphorylation of DNA polymerase epsilon subunit, dpb2, by the cdc28 cyclin-dependent protein kinase. J Biol Chem 279: 14245-14255, 2004.
12. Jaszczur M, Rudzka J, Kraszewska J, Flis K, Polaczek P, Campbell JL, Fijalkowska IJ and Jonczyk P: Defective interaction between pol2p and dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiae. Mutat Res 669: 27-35, 2009.
13. Kleihues P and Cavenee WK: World Health Organization Classification of Tumours: Pathology and Genetics: Tumours of the Nervous System. Lyon: IARC Press, 2000.
14. Zhou Q, Effati R, Talvinen K, Pospiech H, Syväoja J and Collan Y: Genomic change of the 55 kDa subunit of DNA polymerase ε in human breast cancer. Cancer Genomics Proteomics 5: 287-292, 2008.
15. Huang D, Jokela M , Tuusa J, Skog S, Poikonen K and Syväoja JE: E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ε B-subunit gene POLE2. Nucleic Acids Res 29: 2810-2821, 2001. (Pubitemid 32685045)
16. Zhou Q, Talvinen K, Sundström J, Elzagheid A, Pospiech H, Syväoja J and Collan Y: Mutations/polymorphisms in the 55 kDa subunit of DNA polymerase ε in human colorectal cancer. Cancer Genomics Proteomics 6: 297-304, 2009.
17. Fodde R and Losekoot M: Mutation detection by denaturing gradient gel electrophoresis (DGGE). Hum Mutat 3: 83-94, 1994. (Pubitemid 24077224)
18. Raudenska M, Bittnerova A, Novotny T, Florianova A, Chroust K, Gaillyova R, Semrad B, Kadlecova J, Sisakova M, Toman O and Spinar J: Mutation analysis of candidate genes SCN1B, KCND3 and ANK2 in patients with clinical diagnosis of long QT syndrome. Physiol Res 57: 857-862, 2008.