A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana

Natural Product Communications

Volumn 3, Issue 11, 2008, Pages 1875-1878

  Bayor, Marcel T ^a,b   Ayim, John S K ^a   Marston, Gemma ^b   Phillips, Roger M ^b   Shnyder, Steven D ^b   Wheelhouse, Richard T ^a,b   Wright, Colin W ^a  

^a KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Crotomembranafuran; Croton membranaceus; Cytotoxicity; Prostate cancer

Indexed keywords

14 CLERODATRIEN 17,18 DIOIC ACID DIMETHYL ESTER; ANTINEOPLASTIC AGENT; CROTON MEMBRANACEUS EXTRACT; DITERPENOID; DOXORUBICIN; FLUOROURACIL; FURANO CLERODANE DITERPENOID; GLUTARIMIDE ALKALOID; GOMOJOSIDE H; JULOCROTINE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CANCER CELL CULTURE; CANCER THERAPY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CROTOMEMBRANAFURAN; CROTON; CROTON MEMBRANACEUS; CYTOTOXICITY; DRUG CYTOTOXICITY; DRUG FORMULATION; DRUG ISOLATION; FRACTIONATION; GHANA; HUMAN; HUMAN CELL; IC 50; MEDICINAL PLANT; PROSTATE CANCER; STEREOCHEMISTRY;

CROTON MEMBRANACEUS;

EID: 77954129793     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0800301116     Document Type: Article

References (12)

1. Bayor MT. (2008) The Anticancer and other Bioactivity Investigations on the Extract and Some Compounds of Croton membranaceus (Euphorbiaceae); Ph.D. dissertation, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
2. Krebs HC, Ramiarantsoa H. (1997) Clerodane diterpenes of Croton hovarum. Phytochemistry, 45, 379-381.
3. Ngadjui BT, Abegaz, BM, Keumedjio F, Folefoc GN. (2002) Diterpenoids from the stem bark of Croton zambesicus. Phytochemistry, 60, 345-349. (Pubitemid 34619884)
4. Silveira ER, McChesney JD. (1994) 6,7-Oxygenated neoclerodane furan diterpenes from Croton sonderianus. Phytochemistry, 36, 1457-1463.
5. Vigor C, Fabre N, Fouraste I, Moulis C. (2001) Three clerodane diterpenoids from Croton elutaria Bennett. Phytochemistry, 57, 1209-1212. (Pubitemid 32681496)
6. Ngadjui BT, Abegaz BM, Keumedjio F, Dongo E, Sondengam BL, Connolly JD. (2002) Crotonadiol, a labdane diterpenoid from the stem bark of Croton zambesicus. Phytochemistry, 51, 171-174.
7. Hanson JR. (2004) Diterpenoids. Natural Products Reports, 21, 312-320.
8. Aboagye FA, Sam GH, Massiot G, Lavaud C. (2000) Julocrotine, a glutarimide alkaloid from Croton membranaceus. Fitoterapia, 71, 461-462. (Pubitemid 30488168)
9. Bilia AR, Mendez J, Morelli I. (1996) Phytochemical investigation of Licania genus. Flavonoids from Licania pyrifolia. Pharmaceutica Acta Helvetiae, 71, 191-197. (Pubitemid 26290617)
10. Iwagawa T, Yaguchi S, Hase T, Okubo T, Kim M. (1992) Gomojosides, labdane diterpenoids from Viburnum suspensum. Phytochemistry, 31, 1311-1315.
11. Ishikawa T, Kudo M, Kitajima J. (2002) Water soluble constituents of dill. Chemical and Pharmaceutical Bulletin. 50, 501-507.
12. Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55-63.