Positive identification of CA215 pan cancer biomarker from serum specimens of cancer patients

Cancer Biomarkers

Volumn 6, Issue 2, 2009, Pages 111-117

  Lee, Gregory ^a   Ge, Bixia ^a   Huang, Teng Kai ^a   Zheng, Gary ^a   Duan, Jiantao ^a   Wang, Ida Hsiao Yun ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

CA215 pan cancer biomarker; cancer cell derived immunoglobulins; enzyme immunoassay; RP215 monoclonal antibody; western blot assay

Indexed keywords

ALPHA FETOPROTEIN; BETA 2 MICROGLOBULIN; CA 125 ANTIGEN; CA 15-3 ANTIGEN; CA 19-9 ANTIGEN; CA215 ANTIGEN; CARBOHYDRATE; CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN 19 FRAGMENT; EPITOPE; FERRITIN; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; PROSTATE SPECIFIC ANTIGEN; TUMOR ANTIGEN; TUMOR MARKER; UNCLASSIFIED DRUG;

ANTIGEN DETECTION; ARTICLE; BREAST CANCER; CANCER PATIENT; COLON CANCER; CONTROLLED STUDY; ESOPHAGUS CANCER; HUMAN; IMMUNOASSAY; IMMUNOGLOBULIN BLOOD LEVEL; KIDNEY CANCER; LIVER CANCER; LUNG CANCER; LYMPHOMA; MAJOR CLINICAL STUDY; MOLECULAR SIZE; OVARY CANCER; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; STOMACH CANCER; UTERINE CERVIX CANCER; WESTERN BLOTTING;

ANTIGENS, NEOPLASM; HUMANS; NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 77954111204     PISSN: 15740153     EISSN: None     Source Type: Journal    
DOI: 10.3233/CBM-2009-0134     Document Type: Article

References (15)

1. M.J. Duffy, Evidence for the clinical use of tumor markers, Ann Clin Biochem 41 (2004), 370-377.
2. W.D. Dunsmuir, C.E. Gillett, L.C. Meyer, M.P. Young, C. Corbishley, R.A. EELES and R.S. Kirby, Molecular markers for predicting prostate cancer stage and survival, BJU International 86 (2001), 869-878.
3. H. Hagberg, A. Killander and B. Simonsson, Serum beta 2- microglobulin in malignant lymphoma, Cancer 15 (1983), 2220-2225.
4. I. Hellstroem, J. Raycraft, M. Hayden-Ledbetter, J.A. Ledbetter, M. Schummer, M. McIntosh, C. Drescher, N. Urban and K.E. Hellstroem, The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma, Cancer Res 63 (2003), 3695-3700.
5. W.H. Hsu, C.S. Huang, H.S. Hsu,W.J. Huang, H.C. Lee, B.S. Huang and M.H. Huang, Preoperative serum carcinoembryonic antigen level is a prognostic factor in women with early non-small-cell lung cancer, Ann Thorac Surg 83 (2007), 419-424.
6. G. Lee, Cancer cell-expressed immunoglobulins: CA215 as a pan cancer marker and its diagnostic applications, Cancer Biomarkers 5 (2009), 137-142.
7. G. Lee, R.Y. Chu and H.H. Ting, Preclinical assessment of anti-cancer drugs by using RP215 monoclonal antibody, Cancer Biology and Therapy 8 (2009), 161-166.
8. G. Lee, B. Ge, Cancer cell expressions of immunoglobulin heavy chains with unique carbohydrate-associated biomarker, Cancer Biomarkers 5 (2009), 177-188.
9. G. Lee, E. Laflamme, C.H. Chien and H.-H. Ting, Molecular identity of a pan cancer marker, CA215, Cancer Biology and Therapy 7 (2008), 91-98.
10. G.Y. Locker, S. Hamilton, J. Harris, J.M. Jessup, N. Kemeny, J.S. Macdonald, M.R. Somerfield, D.F. Hayes and R.C. Bast, Jr., ASCO 2006 Update of recommendations for the use of tumor markers in gastrointestinal cancer, J Clin Onco 24 (2006), 5313-5327.
11. K. Matsuoka, S. Sumitomo, N. Nakashima, D. Nakajima and N. Misaki, Prognostic value of carcinoembryonic antigen and CYFRA21-1 in patients with pathological stage I non-small cell lung cancer, Eur J Cardiothorac Surg 32 (2007), 435-439.
12. S. Mizuguchi, N. Nishiyama, T. Iwata, T. Nishida, N. Izumi, T. Tsukioka, K. Inoue, M. Kameyama and S. Suehiro, Clinical value of serum cytokeratin 19 fragment and sialyl-lewis X in non-small cell lung cancer, Ann Thorac Surg 83 (2007), 216-221.
13. J. M. Porcel, M. Vives, A. Esquerda, A. Salud, B. Perez and F. Rodriguez-Panadero, Use of a panel of tumor markers (carcinoembryonic antigen, cancer antigen 125, carbohydrate antigen 15-3 and cytokeratin 19 fragments) in pleural fluid for the differential diagnosis of benign and malignant effusions, CHEST 126 (2004), 1757-1763.
14. E. Seregni, A. Coli and N. Mazzucca, Circulating tumor markers in breast cancer, Eur J, Nucl Med Mol Imaging 31 (2004), S15-S22.
15. D.S.Yamamoto, P.H.Viale, K. Rosser and A. Lin, The clinical use of tumor markers in selected cancers: Are you confident enough to discuss them with your patients? Oncology Nursing Forum 32 (2005), 1013-1022.