Chemoselective regulation of TREK2 channel: Activation by sulfonate chalcones and inhibition by sulfonamide chalcones

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 14, 2010, Pages 4237-4239

  Kim, Eun Jin ^b   Ryu, Hyung Won ^a   Curtis Long, Marcus J ^c   Han, Jaehee ^b   Kim, Jun Young ^a   Cho, Jung Keun ^a   Kang, Dawon ^b   Park, Ki Hun ^a  

^a Gyeongsang National University   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

^c NONE   (United Kingdom)

Author keywords

Sulfonamide chalcone; Sulfonate chalcone; TREK2 channel

Indexed keywords

CHALCONE DERIVATIVE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; SULFONAMIDE CHALCONE; SULFONATE CHALCONE; TREK2 CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG SYNTHESIS; IC 50; INHIBITION KINETICS; STRUCTURE ACTIVITY RELATION;

EID: 77954089698     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.05.033     Document Type: Article

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