Sulfonate chalcone as new class voltage-dependent K+ channel blocker

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 137-140

  Yarishkin, Oleg V ^b   Ryu, Hyung Won ^a   Park, Jae Yong ^b   Yang, Min Suk ^a   Hong, Seong Geun ^b   Park, Ki Hun ^a  

^a Gyeongsang National University   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Chalcone; Ion channel; K+ channel blocker; Potassium channel blocker; Sulfonate chalcone

Indexed keywords

3' (4 AMINOBENZENESULFONYLHYDROXY) 4 HYDROXYCHALCONE; CHALCONE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; SULFONATE CHALCONE DERIVATIVE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL;

ARTICLE; CELL STRAIN HEK293; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; PATCH CLAMP; POTASSIUM CURRENT; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ALKANESULFONATES; ANIMALS; CHALCONES; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS;

EID: 37549024596     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.114     Document Type: Article

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25. 3OD) δ 6.85 (2H, d, J = 8.5 Hz), 7.17 (2H, d, J = 8.7 Hz), 7.53 (2H, d, J = 15.5 Hz), 7.64 (3H, m), 7.75 (2H, m), 7.88 (2H, d, J = 8.3 Hz), and 8.05 (2H, d, J = 8.7 Hz).
26. 6) δ 6.93 (2H, d, J = 8.6 Hz), 7.28 (2H, d, J = 8.9 Hz), 7.70 (4H, m), 8.15 (2H, d, J = 8.8 Hz), 8.22 (2H, d, J = 9.0 Hz), and 8.53 (2H, d, J = 9.0 Hz).
27. 3OD) δ 6.66 (2H, m), 6.84 (2H, d, J = 8.6 Hz), 7.13 (2H, d, J = 8.7 Hz), 7.48 (3H, m), 7.59 (2 H, d, J = 8.7 Hz), 7.72 (1H, d, J = 15.5 Hz), and 7.99 (2H, d, J = 8.7 Hz).
28. 6) δ 6.45 (2H, s), 6.63 (2H, d, J = 8.7 Hz), 7.18 (2H, d, J = 8.6 Hz), 7.46 (5H, m), 7.74 (1H, d, J = 15.6 Hz), 7.89 (1H, s), and 8.17 (2H, d, J = 8.6 Hz).
29. 3OD) δ 6.67 (2H, d, J = 8.8 Hz), 6.85 (2H, d, J = 8.6 Hz), 7.22 (1H, m), 7.32 (1H, d, J = 15.5 Hz), 7.45 (3H, m), 7.56 (3H, m), 7.69 (1H, d, J = 15.5 Hz), and 7.90 (1H, d, J = 7.8 Hz).