Nogo-A antibodies and training reduce muscle spasms in spinal cord-injured rats

Annals of Neurology

Volumn 68, Issue 1, 2010, Pages 48-57

  Gonzenbach, Roman R ^a   Gasser, Pascal ^a,b   Zörner, Björn ^a   Hochreutener, Eva ^a   Dietz, Volker ^b   Schwab, Martin E ^a,b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BACLOFEN; NOGO A ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DRUG DOSE INCREASE; FEMALE; LOCOMOTION; LOW DRUG DOSE; MUSCLE SPASM; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; SWIMMING; TREADMILL EXERCISE; URINARY TRACT INFECTION; WATER TEMPERATURE;

ANIMALS; ANTIBODIES, MONOCLONAL; DISEASE MODELS, ANIMAL; EXERCISE THERAPY; FEMALE; IMMUNOLOGIC FACTORS; LOCOMOTION; MYELIN PROTEINS; RATS; RATS, INBRED LEW; RECOVERY OF FUNCTION; SPASM; SPINAL CORD INJURIES; TIME FACTORS; TREATMENT OUTCOME;

EID: 77954075805     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.22009     Document Type: Article

References (38)

1. Hsieh JT, Wolfe DL, Miller WC, Curt A. Spasticity outcome measures in spinal cord injury: psychometric properties and clinical utility. Spinal Cord 2008;46:86-95.
2. Hiersemenzel LP, Curt A, Dietz V. From spinal shock to spasticity: neuronal adaptations to a spinal cord injury. Neurology 2000;54:1574-1582.
3. Dietz V, Sinkjaer T. Spastic movement disorder: impaired reflex function and altered muscle mechanics. Lancet Neurol 2007;6: 725-733.
4. Frigon A, Rossignol S. Functional plasticity following spinal cord lesions. Prog Brain Res 2006;157:231-260.
5. Raineteau O, Schwab ME. Plasticity of motor systems after incomplete spinal cord injury. Nat Rev Neurosci 2001;2:263-273. (Pubitemid 33673067)
6. Li Y, Gorassini MA, Bennett DJ. Role of persistent sodium and calcium currents in motoneuron firing and spasticity in chronic spinal rats. J Neurophysiol 2004;91:767-783. (Pubitemid 38168850)
7. Bennett DJ, Sanelli L, Cooke CL, et al. Spastic long-lasting reflexes in the awake rat after sacral spinal cord injury. J Neurophysiol 2004;91:2247-2258. (Pubitemid 38500940)
8. Kakinohana O, Hefferan MP, Nakamura S, et al. Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study. Neuroscience 2006;141:1569-1583.
9. Bose P, Parmer R, Thompson FJ. Velocity-dependent ankle torque in rats after contusion injury of the midthoracic spinal cord: time course. J Neurotrauma 2002;19:1231-1249. (Pubitemid 35203291)
10. Liebscher T, Schnell L, Schnell D, et al. Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Ann Neurol 2005;58:706-719.
11. Freund P, Schmidlin E, Wannier T, et al. Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates. Nat Med 2006;12:790-792.
12. Gonzenbach RR, Schwab ME. Disinhibition of neurite growth to repair the injured adult CNS: focusing on Nogo. Cell Mol Life Sci 2008;65:161-176.
13. Yiu G, He Z. Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 2006;7:617-627.
14. Baptiste DC, Fehlings MG. Update on the treatment of spinal cord injury. Prog Brain Res 2007;161:217-233.
15. Romero MI, Rangappa N, Li L, et al. Extensive sprouting of sensory afferents and hyperalgesia induced by conditional expression of nerve growth factor in the adult spinal cord. J Neurosci 2000;20:4435-4445.
16. Hofstetter CP, Holmstrom NA, Lilja JA, et al. Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. Nat Neurosci 2005;8:346-353.
17. Wirz M, Zemon DH, Rupp R, et al. Effectiveness of automated locomotor training in patients with chronic incomplete spinal cord injury: a multicenter trial. Arch Phys Med Rehabil 2005;86: 672-680.
18. Kiser TS, Reese NB, Maresh T, et al. Use of a motorized bicycle exercise trainer to normalize frequency-dependent habituation of the H-reflex in spinal cord injury. J Spinal Cord Med 2005;28: 241-245.
19. Kaegi S, Schwab ME, Dietz V, Fouad K. Electromyographic activity associated with spontaneous functional recovery after spinal cord injury in rats. Eur J Neurosci 2002;16:249-258.
20. Adams MM, Hicks AL. Spasticity after spinal cord injury. Spinal Cord 2005;43:577-586.
21. Dietz V, Quintern J, Berger W. Electrophysiological studies of gait in spasticity and rigidity. Evidence that altered mechanical properties of muscle contribute to hypertonia. Brain 1981;104: 431-449.
22. Priebe MM, Sherwood AM, Thornby JI, et al. Clinical assessment of spasticity in spinal cord injury: a multidimensional problem. Arch Phys Med Rehabil 1996;77:713-716.
23. Skold C. Spasticity in spinal cord injury: self- and clinically rated intrinsic fluctuations and intervention-induced changes. Arch Phys Med Rehabil 2000;81:144-149.
24. Matsumoto S, Kawahira K, Etoh S, et al. Short-term effects of thermotherapy for spasticity on tibial nerve F-waves in poststroke patients. Int J Biometeorol 2006;50:243-250. (Pubitemid 43312116)
25. Shirado O, Shundo M, Kaneda K, Strax TE. Outdoor winter activities of spinal cord-injured patients. With special reference to outdoor mobility. Am J Phys Med Rehabil 1995;74:408-414. (Pubitemid 26005307)
26. Billig I, Hartge K, Card JP, Yates BJ. Transneuronal tracing of neural pathways controlling abdominal musculature in the ferret. Brain Res 2001;912:24-32. (Pubitemid 32772789)
27. Thallmair M, Metz GA, Z'Graggen WJ, et al. Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions. Nat Neurosci 1998;1:124-131. (Pubitemid 128652659)
28. Mullner A, Gonzenbach RR, Weinmann O, et al. Lamina-specific restoration of serotonergic projections after Nogo-A antibody treatment of spinal cord injury in rats. Eur J Neurosci 2008;27:326-333.
29. Cote MP, Gossard JP. Task-dependent presynaptic inhibition. J Neurosci 2003;23:1886-1893.
30. Edgerton VR, Courtine G, Gerasimenko YP, et al. Training locomotor networks. Brain Res Rev 2008;57:241-254.
31. Bareyre FM, Haudenschild B, Schwab ME. Long-lasting sprouting and gene expression changes induced by the monoclonal antibody IN-1 in the adult spinal cord. J Neurosci 2002;22: 7097-7110. (Pubitemid 35379165)
32. Bareyre FM, Kerschensteiner M, Raineteau O, et al. The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat Neurosci 2004;7:269-277.
33. Maier IC, Baumann K, Thallmair M, et al. Constraint-induced movement therapy in the adult rat after unilateral corticospinal tract injury. J Neurosci 2008;28:9386-9403.
34. Dietz V, Muller R. Degradation of neuronal function following a spinal cord injury: mechanisms and countermeasures. Brain 2004; 127:2221-2231.
35. Cote MP, Menard A, Gossard JP. Spinal cats on the treadmill: changes in load pathways. J Neurosci 2003;23:2789-2796.
36. Cote MP, Gossard JP. Step training-dependent plasticity in spinal cutaneous pathways. J Neurosci 2004;24:11317-11327.
37. Reese NB, Skinner RD, Mitchell D, et al. Restoration of frequency-dependent depression of the H-reflex by passive exercise in spinal rats. Spinal Cord 2006;44:28-34.
38. Skinner RD, Houle JD, Reese NB, et al. Effects of exercise and fetal spinal cord implants on the H-reflex in chronically spinalized adult rats. Brain Res 1996;729:127-131.