Feline hypertrophic cardiomyopathy: An update

Veterinary Clinics of North America - Small Animal Practice

Volumn 40, Issue 4, 2010, Pages 685-700

  Abbott, Jonathan A ^a  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

Author keywords

Feline; Feline myocardial disease; Hypertrophic cardiomyopathy

Indexed keywords

ALDOSTERONE; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAIN NATRIURETIC PEPTIDE; DILTIAZEM; ENALAPRIL; FUROSEMIDE; PLACEBO; PROPRANOLOL; RAMIPRIL; SPIRONOLACTONE; VERAPAMIL;

CAT DISEASE; CLINICAL FEATURE; CONGESTIVE HEART FAILURE; DIASTOLIC DYSFUNCTION; DISEASE COURSE; DRUG EFFICACY; ECHOCARDIOGRAPHY; GENE MUTATION; GENETIC HETEROGENEITY; HEART FAILURE; HEART LEFT VENTRICLE OUTFLOW TRACT OBSTRUCTION; HEART MURMUR; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; LUNG EDEMA; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PREVALENCE; PROGNOSIS; PROTEIN ANALYSIS; REVIEW; SEX DIFFERENCE; ANIMAL; CARDIOMYOPATHY, HYPERTROPHIC; CAT; CAT DISEASES; FEMALE; MALE; VETERINARY;

FELIDAE;

ANIMALS; CARDIOMYOPATHY, HYPERTROPHIC; CAT DISEASES; CATS; ECHOCARDIOGRAPHY; FEMALE; MALE; PROGNOSIS;

EID: 77954036640     PISSN: 01955616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cvsm.2010.04.004     Document Type: Review

References (83)

1. Maron B.J., Towbin J.A., Thiene G., et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 2006, 113:1807-1816.
2. Thiene G., Corrado D., Basso C. Cardiomyopathies: is it time for a molecular classification?. Eur Heart J 2004, 25:1772-1775.
3. Meurs K.M., Sanchez X., David R.M., et al. A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy. Hum Mol Genet 2005, 14:3587-3593.
4. Meurs K.M., Norgard M.M., Ederer M.M., et al. A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy. Genomics 2007, 90:261-264.
5. Richardson P., McKenna W., Bristow M., et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies. Circulation 1996, 93:841-842.
6. Maron B.J., McKenna W.J., Elliott P., et al. Hypertrophic cardiomyopathy. JAMA 1999, 282:2302-2303.
7. Maron B.J., Epstein S.E. Hypertrophic cardiomyopathy: a discussion of nomenclature. Am J Cardiol 1979, 43:1242-1244.
8. Maron B.J., McKenna W.J., Danielson G.K., et al. ACC/ESC Clinical expert document on hypertrophic cardiomyopathy: a report of American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and European Society of Cardiology Committee for Practice Guidelines. J Am Coll Cardiol 2003, 42:1687-1713.
9. Roberts W.C. Fifty years of hypertrophic cardiomyopathy. Am J Cardiol 2009, 103:431-434.
10. Buchanan J., Baker G., Hill J. Aortic embolism in cats: prevalence, surgical treatment and electrocardiography. Vet Rec 1966, 79:496-506.
11. Holzworth J. University of Pennsylvania Veterinary Extension Quarterly. 1958;151:101.
12. Liu S.K. Acquired cardiac lesions leading to congestive heart failure in the cat. Am J Vet Res 1970, 31:2071-2088.
13. Harpster N. Acquired heart disease in the cat. In: 40th Annual Meeting of the American Animal Hospital Association. San Antonio (TX), April 8--13, 1973. Southbend (IN): American Animal Hospital Association. p. 118.
14. Tilley L. Feline cardiology. Vet Clin North Am 1976, 6:415-432.
15. Liu S.K., Tilley L.P. Animal models of primary myocardial diseases. Yale J Biol Med 1980, 53:191-211.
16. Moise N.S., Dietze A.E., Mezza L.E., et al. Echocardiography, electrocardiography, and radiography of cats with dilatation cardiomyopathy, hypertrophic cardiomyopathy, and hyperthyroidism. Am J Vet Res 1986, 47:1476-1486.
17. Maron B.J. Hypertrophic cardiomyopathy: a systematic review. JAMA 2002, 287:1308-1320.
18. Jarcho J.A., McKenna W., Pare J.A., et al. Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1. N Engl J Med 1989, 321:1372-1378.
19. Geisterfer-Lowrance A.A.T., Kass S., Tanigawa G., et al. A molecular basis for familial hypertrophic cardiomyopathy: a [beta] cardiac myosin heavy chain gene missense mutation. Cell 1990, 62:999-1006.
20. Marian A.J. Hypertrophic cardiomyopathy: from genetics to treatment. Eur J Clin Invest 2010, 40:360-369.
21. Bos J.M., Ommen S.R., Ackerman M.J. Genetics of hypertrophic cardiomyopathy: one, two, or more diseases?. Curr Opin Cardiol 2007, 22:193-199.
22. Kraus M.S., Calvert C.A., Jacobs G.J. Hypertrophic cardiomyopathy in a litter of five mixed-breed cats. J Am Anim Hosp Assoc 1999, 35:293-296.
23. Marin L., VandeWoude S., Boon J., et al. Left ventricular hypertrophy in a closed colony of Persian cats [abstract]. J Vet Intern Med 1994, 8:143.
24. Meurs K.M., Kittleson M.D., Towbin J., et al. Familial systolic anterior motion of the mitral valve and/or hypertrophic cardiomyopathy is apparently inherited as an autosomal dominant trait in a family of American shorthair cats. J Vet Intern Med 1997, 11:138.
25. Nicol R.L., Frey N., Olson E.N. From the sarcomere to the nucleus: role of genetics and signaling in structural heart disease. Annu Rev Genomics Hum Genet 2000, 1:179-223.
26. Tardiff J. Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes. Heart Fail Rev 2005, 10:237-248.
27. Roberts R., Sigwart U. Current concepts of the pathogenesis and treatment of hypertrophic cardiomyopathy. Circulation 2005, 112:293-296.
28. Tsybouleva N., Zhang L., Chen S., et al. Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy. Circulation 2004, 109:1284-1291.
29. Atkins C.E., Gallo A.M., Kurzman I.D., et al. Risk factors, clinical signs, and survival in cats with a clinical diagnosis of idiopathic hypertrophic cardiomyopathy: 74 cases (1985-1989). J Am Vet Med Assoc 1992, 201:613-618.
30. Rush J.E., Freeman L.M., Fenollosa N.K., et al. Population and survival characteristics of cats with hypertrophic cardiomyopathy: 260 cases (1990-1999). J Am Vet Med Assoc 2002, 220:202-207.
31. Fox P.R., Liu S.-K., Maron B.J. Echocardiographic assessment of spontaneously occurring feline hypertrophic cardiomyopathy: an animal model of human disease. Circulation 1995, 92:2645-2651.
32. Smith S.A., Tobias A.H., Fine D.M., et al. Corticosteroid-associated congestive heart failure in 12 cats. Int J Appl Res Vet Med 2004, 2:159-170.
33. Cote E., Manning A.M., Emerson D., et al. Assessment of the prevalence of heart murmurs in overtly healthy cats. J Am Vet Med Assoc 2004, 225:384-388.
34. Gundler S., Tidholm A., Haggstrom J. Prevalence of myocardial hypertrophy in a population of asymptomatic Swedish Maine coon cats. Acta Vet Scand 2008, 50:22.
35. Riesen S.C., Kovacevic A., Lombard C.W., et al. Echocardiographic screening of purebred cats: an overview from 2002 to 2005. Schweiz Arch Tierheilkd 2007, 149:73-76.
36. Paige C.F., Abbott J.A., Pyle R.L., et al. Prevalence of cardiomyopathy in apparently healthy cats. J Am Vet Med Assoc 2009, 234:1398-1403.
37. Wagner T., Luis Fuentes V., McDermott N., et al. Association between cardiac murmurs and left ventricular hypertrophy in 199 healthy adult cats. J Vet Intern Med 2009, 23:1332. [abstract #29].
38. Maron B.J., Gardin J.M., Flack J.M., et al. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults. Circulation 1995, 92:785-789.
39. Goda A., Yamashita T., Suzuki S., et al. Prevalence and prognosis of patients with heart failure in Tokyo: a prospective cohort of Shinken Database 2004-5. Int Heart J 2009, 50:609-625.
40. Maron B.J., Peterson E.E., Maron M.S., et al. Prevalence of hypertrophic cardiomyopathy in an outpatient population referred for echocardiographic study. Am J Cardiol 1994, 73:577-580.
41. Connolly D.J., Soares Magalhaes R.J., Fuentes V.L., et al. Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress. J Vet Cardiol 2009, 11:S41-50.
42. Fox P.R., Oyama M.A., Reynolds C., et al. Utility of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) to distinguish between congestive heart failure and non-cardiac causes of acute dyspnea in cats. J Vet Cardiol 2009, 11:S51-61.
43. Fox P. Feline cardiomyopathies. Textbook of canine and feline cardiology: principles and practice 1999, 621-678. WB Saunders Co, Philadelphia. 2nd edition. P.R. Fox, D. Sisson, N.S. Moise (Eds.).
44. Sherrid M.V. Pathophysiology and treatment of hypertrophic cardiomyopathy. Prog Cardiovasc Dis 2006, 49:123-151.
45. Sherrid M.V., Gunsburg D.Z., Moldenhauer S., et al. Systolic anterior motion begins at low left ventricular outflow tract velocity in obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol 2000, 36:1344-1354.
46. Levine R.A., Vlahakes G.J., Lefebvre X., et al. Papillary muscle displacement causes systolic anterior motion of the mitral valve. Experimental validation and insights into the mechanism of subaortic obstruction. Circulation 1995, 91:1189-1195.
47. Paige C.F., Abbott J.A., Pyle R.L. Systolic anterior motion of the mitral valve associated with right ventricular systolic hypertension in 9 dogs. J Vet Cardiol 2007, 9:9-14.
48. Maron B.J., Maron M.S., Wigle E.D., et al. The 50-year history, controversy, and clinical implications of left ventricular outflow tract obstruction in hypertrophic cardiomyopathy: from idiopathic hypertrophic subaortic stenosis to hypertrophic cardiomyopathy. J Am Coll Cardiol 2009, 54:191-200.
49. Maron M.S., Olivotto I., Betocchi S., et al. Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. N Engl J Med 2003, 348:295-303.
50. Blanksma P.K. Is regional wall stress a stimulus for myocardial hypertrophy in hypertrophic cardiomyopathy?. Z Kardiol 1987, 76(Suppl 3):57-60.
51. Deb S.J., Schaff H.V., Dearani J.A., et al. Septal myectomy results in regression of left ventricular hypertrophy in patients with hypertrophic obstructive cardiomyopathy. Ann Thorac Surg 2004, 78:2118-2122.
52. Knaapen P., Germans T., Camici P.G., et al. Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol 2008, 294:H986-993.
53. Celik S., Dagdeviren B., Yildirim A., et al. Comparison of coronary flow velocities between patients with obstructive and nonobstructive type hypertrophic cardiomyopathy: noninvasive assessment by Transthoracic Doppler Echocardiography. Echocardiography 2005, 22:1-7.
54. Maron M.S., Olivotto I., Maron B.J., et al. The case for myocardial ischemia in hypertrophic cardiomyopathy. J Am Coll Cardiol 2009, 54:866-875.
55. Liu S.K., Roberts W.C., Maron B.J. Comparison of morphologic findings in spontaneously occurring hypertrophic cardiomyopathy in humans, cats and dogs. Am J Cardiol 1993, 72:944-951.
56. Efthimiadis G.K., Parcharidou D.G., Giannakoulas G., et al. Left ventricular outflow tract obstruction as a risk factor for sudden cardiac death in hypertrophic cardiomyopathy. Am J Cardiol 2009, 104:695-699.
57. Kizilbash A.M., Heinle S.K., Grayburn P.A. Spontaneous variability of left ventricular outflow tract gradient in hypertrophic obstructive cardiomyopathy. Circulation 1998, 97:461-466.
58. Geske J.B., Sorajja P., Ommen S.R., et al. Left ventricular outflow tract gradient variability in hypertrophic cardiomyopathy. Clin Cardiol 2009, 32:397-402.
59. Maron M.S., Olivotto I., Zenovich A.G., et al. Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction. Circulation 2006, 114:2232-2239.
60. Rishniw M., Thomas W.P. Dynamic right ventricular outflow obstruction: a new cause of systolic murmurs in cats. J Vet Intern Med 2002, 16:547-552.
61. Kittleson M.D., Meurs K.M., Munro M.J., et al. Familial hypertrophic cardiomyopathy in Maine coon cats: an animal model of human disease. Circulation 1999, 99:3172-3180.
62. Abbott J.A., MacLean H.N. Two-dimensional echocardiographic assessment of the feline left atrium. J Vet Intern Med 2006, 20:111-119.
63. Nistri S., Olivotto I., Betocchi S., et al. Prognostic significance of left atrial size in patients with hypertrophic cardiomyopathy (from the Italian registry for hypertrophic cardiomyopathy). Am J Cardiol 2006, 98:960-965.
64. Fox P.R. Hypertrophic cardiomyopathy. Clinical and pathologic correlates. J Vet Cardiol 2003, 5:39-45.
65. Kubo T., Gimeno J.R., Bahl A., et al. Prevalence, clinical significance, and genetic basis of hypertrophic cardiomyopathy with restrictive phenotype. J Am Coll Cardiol 2007, 49:2419-2426.
66. Nishimura R.A., Ommen S.R. Hypertrophic cardiomyopathy: the search for obstruction. Circulation 2006, 114:2200-2202.
67. Shah J.S., Esteban M.T., Thaman R., et al. Prevalence of exercise-induced left ventricular outflow tract obstruction in symptomatic patients with non-obstructive hypertrophic cardiomyopathy. Heart 2008, 94:1288-1294.
68. Liu S.-K., Maron B.J., Tilley L.P. Feline hypertrophic cardiomyopathy: gross anatomic and quantitative histologic features. Am J Pathol 1981, 102:388-395.
69. Sisson D.D., Knight D.H., Helinski C., et al. Plasma taurine concentrations and M-mode echocardiographic measures in healthy cats and in cats with dilated cardiomyopathy. J Vet Intern Med 1991, 5:232-238.
70. Drourr L., Lefbom B.K., Rosenthal S.L., et al. Measurement of M-mode echocardiographic parameters in healthy adult Maine Coon cats. J Am Vet Med Assoc 2005, 226:734-737.
71. Connolly D.J., Soares Magalhaes R.J., Syme H.M., et al. Circulating natriuretic peptides in cats with heart disease. J Vet Intern Med 2008, 22:96-105.
72. Wess G., Daisenberger P., Hirschberger J., et al. The utility of NT-proBNP to detect early stages of hypertrophic cardiomyopathy in cats and to differentiate disease stages. J Vet Intern Med 2009, 23:687. [abstract 9].
73. Fox P.R., Oyama M.A., MacDonald K.A., et al. Assessment of NT proBNP concentration in asymptomatic cats with cardiomyopathy. J Vet Intern Med 2008, 22:759. [abstract 191].
74. Hsu A., Kittleson M.D., Paling A. Investigation into the use of plasma NT-proBNP concentration to screen for feline hypertrophic cardiomyopathy. J Vet Cardiol 2009, 11(Suppl 1):S63-70.
75. Baty C.J., Malarkey D.E., Atkins C.E., et al. Natural history of hypertrophic cardiomyopathy and aortic thromboembolism in a family of domestic shorthair cats. J Vet Intern Med 2001, 15:595-599.
76. Fox P.R. Prospective, double-blinded, multicenter evaluation of chronic therapies for feline diastolic heart failure: interim analysis [abstract]. J Vet Intern Med 2003, 17:398.
77. MacDonald K.A., Kittleson M.D., Larson R.F., et al. The effect of ramipril on left ventricular mass, myocardial fibrosis, diastolic function, and plasma neurohormones in Maine Coon cats with familial hypertrophic cardiomyopathy without heart failure. J Vet Intern Med 2006, 20:1093-1105.
78. Amberger C.N., Glardon O., Glaus T., et al. Effects of benazepril in the treatment of feline hypertrophic cardiomyopathy: results of a prospective, open-label, multicenter clinical trial. J Vet Cardiol 1999, 1:19-26.
79. MacDonald K.A., Kittleson M.D., Kass P.H. Effect of spironolactone on diastolic function and left ventricular mass in Maine Coon cats with familial hypertrophic cardiomyopathy. J Vet Intern Med 2008, 22:335-341.
80. Johnson LM, Atkins CE, Keene BW, et al. Pharmacokinetic and pharmacodynamic properties of conventional and CD-formulated diltiazem in cats. J Vet Intern Med 1996, 10(5):316-320.
81. Bright J.M., Golden A.L., Gompf R.E., et al. Evaluation of the calcium channel-blocking agents diltiazem and verapamil for treatment of feline hypertrophic cardiomyopathy. J Vet Intern Med 1991, 5:272-282.
82. Rush JE, Freeman LM, Brown DJ, et al. The use of enalapril in the treatment of feline hypertrophic cardiomyopathy. J Am Anim Hosp Assoc 1998, 34:38-41.
83. Fox PR. Newest developments: feline heart disease and management. In: Proceedings of the North American Veterinary Conference. Orlando (FL), January 17-21, 2004. Gainesville (FL): Eastern States Veterinary Association. p. 133-5.