Preventive effects of a fractioned polysaccharide from a traditional Chinese herbal medical formula (Yu Ping Feng San) on carbon tetrachloride- induced hepatic fibrosis

Journal of Pharmacy and Pharmacology

Volumn 62, Issue 7, 2010, Pages 935-942

  Wang, Jia Jia ^a   Li, Jun ^a   Shi, Lei ^a   Lv, Xiong Wen ^a   Cheng, Wen Ming ^a   Chen, Ying Ying ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

liver fibrosis; mechanism; polysaccharide; prevention; Yu Ping Feng San

Indexed keywords

ASTRAGALUS MEMBRANACEUS EXTRACT; CARBON TETRACHLORIDE; COLCHICINE; COLLAGEN TYPE 3; COLLAGEN TYPE 4; COLLAGENASE 3; HERBACEOUS AGENT; HYALURONIC ACID; HYDROXYPROLINE; LAMININ; MESSENGER RNA; POLYSACCHARIDE; PROCOLLAGEN; PROCOLLAGEN 1; PROCOLLAGEN TYPE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; YU PING FENG SAN FRACTIONED POLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTRAGALUS MEMBRANACEUS; ATRACTYLODES; ATRACTYLODES MACROCEPHAIA; BIOCHEMISTRY; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HISTOPATHOLOGY; LIVER; LIVER FIBROSIS; MALE; MEDICINAL PLANT; MYOFIBROBLAST; NONHUMAN; PLANT ROOT; RADIOIMMUNOASSAY; RAIDIX SAPOSHNIKOVIAE; RAT; REAL TIME POLYMERASE CHAIN REACTION; RHIZOME; STELLATE CELL; TRANSMISSION ELECTRON MICROSCOPY;

ANGIOSPERMS; ANIMALS; APIACEAE; ASTRAGALUS MEMBRANACEUS; ATRACTYLODES; CARBON TETRACHLORIDE POISONING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; DRUGS, CHINESE HERBAL; FIBRILLAR COLLAGENS; HEPATIC STELLATE CELLS; HYALURONIC ACID; HYDROXYPROLINE; LAMININ; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MATRIX METALLOPROTEINASES; PHYTOTHERAPY; PLANT ROOTS; POLYSACCHARIDES; PROTECTIVE AGENTS; RATS; RHIZOME; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77954000834     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.62.07.0016     Document Type: Article

References (38)

1. Beljaars L et al. Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis. Front Biosci 2002 7 : e214 e222.
2. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005 115 : 209 218.
3. Luk JM et al. Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation. Liver Int 2007 27 : 879 890.
4. Fowell AJ, Iredale JP. Emerging therapies for liver fibrosis. Dig Dis 2006 24 : 174 183.
5. Bensky D, Barolet R. Chinese Herbal Medicine Formulas & Strategies.
6. Xin H et al. Progress in the immunopharmacological study of yupingfeng powder. Zhongguo Zhong Yao Za Zhi 1998 23 : 505 507 in Chinese XT et al. Immunomodulating effects of fractioned polysaccharides isolated from Yu-Ping-Feng-Powder in cyclophosphamide-treated mice. Am J Chin Med 2006 34 : 631 641.
7. Chen FJ et al. Protective effect of polysaccharides from yupingfeng powder on immunological liver injury in mice. Anhui Med Pharm J 2008 12 : 302 304 in Chinese X et al. Deproteinization of gellan gum produced by Sphingomonas paucimobilis ATCC 31461. J Biotechnol 2007 128 : 403 407.
8. Dong Q et al. Modified phenol-sulfuric acid method for determination of the content of oligo- and polysaccharides. Chin Pharm J 1996 31 : 550 553.
9. Lowry OH et al. Protein measurement with the Folin phenol reagent. J Biol Chem 1951 193 : 265 275.
10. Zhang JT. Modern Experimental Methods in Pharmacology (Xian Dai Yao Li Shi Yan Fang Fa Xue).
11. Tsai JH et al. Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. J Viral Hepat 2008 15 : 508 514.
12. Sakaida I et al. The prolyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fibrosis induced by choline-deficient Lamino acid-defined diet. Hepatology 1996 23 : 755 763.
13. Okuno M et al. Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta. Gastroenterology 2001 120 : 1784 1800.
14. Liu R, Bai RH. Ridit analysis with SPSS. Chin J Health Stat 2004 21 : 236 238 in Chinese SL. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 1993 328 : 1828 1835.
15. Horn T et al. Early alcoholic liver injury: activation of lipocytes in acinar zone 3 and correlation to degree of collagen formation in the Disse space. J Hepatol 1986 3 : 333 340.
16. Chen W et al. Isolation, culture and main characteristics of mouse fat-storing cells: interaction with viruses. Hepatology 1989 9 : 352 362.
17. Liu J et al. Serum fibrosis markers in diagnosing liver fibrosis. Zhonghua Nei Ke Za Zhi 2006 45 : 475 477 in Chinese HS et al. Expression of matrix metalloproteinases in spontaneous regression of liver fibrosis. Hepatogastroenterology 2001 48 : 1114 1117.
18. Yoshiji H et al. Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse. Hepatology 2002 36 : 850 860.
19. Olaso E, Friedman SL. Molecular regulation of hepatic fibrogenesis. J Hepatol 1998 29 : 836 847.
20. Arthur MJ. Degradation of matrix proteins in liver fibrosis. Pathol Res Pract 1994 190 : 825 833.
21. Woessner JF Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991 5 : 2145 2154.
22. Hammel P et al. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N Engl J Med 2001 344 : 418 423.
23. Nieto N et al. Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2. J Biol Chem 2000 275 : 20136 20145.
24. Shimizu I et al. Effects of Sho-saiko-to, a Japanese Herbal Medicine, on Hepatic Fibrosis in Rats. Hepatology 1999 29 : 149 160.
25. Kayano K et al. Inhibitory effects of the herbal medicine Shosaiko- to (TJ-9) on cell proliferation and procollagen gene expressions in cultured rat hepatic stellate cells. J Hepatol 1998 29 : 642 649.
26. Wu J, Zern MA. Hepatic stellate cells: a target for the treatment of liver fibrosis. J Gastroenterol 2000 35 : 665 672.
27. Liu X et al. Therapeutic strategies against TGF-b signaling pathway in hepatic fibrosis. Liver Int 2006 26 : 8 22.
28. Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem 1999 274 : 21491 21494.
29. Uchinami H et al. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology 2006 44 : 420 429.
30. Brocks B et al. Generation and optimization of human antagonistic antibodies against TIMP-1 as potential therapeutic agents in fibrotic diseases. Human Antibodies 2006 15 : 115 124.
31. Brenner DA et al. New aspects of hepatic fibrosis. J Hepatol 2000 32 : 32 38.
32. Iredale JP et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998 102 : 538 549.
33. Iredale JP et al. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Hepatology 1996 24 : 176 184.
34. Watanabe T et al. Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride. J Hepatol 2000 33 : 224 235.
35. Hagiwara S et al. Overexpression of NK2 promotes liver fibrosis in carbon tetrachloride-induced chronic liver injury. Liver Int 2007 28 : 126 131.
36. Kuo YR et al. Suppressed TGF-beta1 expression is correlated with up-regulation of matrix metalloproteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment. Lasers Surg Med 2005 36 : 38 42.
37. Sun WY et al. Effects and mechanisms of extract from Paeonia lactiflora and Astragalus membranaceus on liver fibrosis induced by carbon tetrachloride in rats. J Ethnopharmacol 2007 112 : 514 523.
38. Li SP et al. Astragalus polysaccharides and astragalosides regulate cytokines ecretion in LX-2 cellline. Journal of ZheJiang University (Medical Sciences) 2007 36 : 543 548 in Chinese.