Dysregulation of the wnt/β-catenin signaling pathway in canine cutaneous melanotic tumor

Veterinary Pathology

Volumn 47, Issue 2, 2010, Pages 285-291

  Han, J I ^a   Kim, D Y ^b   Na, K J ^a  

^a Chungbuk National University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Canine cutaneous melanotic tumor; Ctnnb1; Immunohistochemistry; Reverse transcription polymerase chain reaction; Wnt catenin signaling pathway

Indexed keywords

BETA CATENIN; RNA; WNT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMISTRY; DNA SEQUENCE; DOG; DOG DISEASE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; METABOLISM; MOLECULAR GENETICS; NONPARAMETRIC TEST; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SKIN TUMOR;

AMINO ACID SEQUENCE; ANIMALS; BETA CATENIN; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; STATISTICS, NONPARAMETRIC; WNT PROTEINS;

EID: 77953989510     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1177/0300985809359303     Document Type: Article

References (25)

1. Bostock DE: Neoplasms of the skin and subcutaneous tissues in dogs and cats. Br Vet J 142:1-19, 1986.
2. Cadigan KM, Nusse R.: Wnt signaling: a common theme in animal development. Genes Dev 11:3286-3305, 1997.
3. Chamberlain AJ, Fritschi L., Kelly JW: Nodular melanoma: patient's perceptions of presenting features and implications for earlier detection. J Am Acad Dermatol 48:694-701, 2003.
4. Danilkovitch-miagkova A., Miagkov A., Skeel A., Nakaigawa N., Zbar B., Leonard EJ: Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the β-catenin pathway. Mol Cell Biol 21:5857-5868, 2001.
5. Delmas V., Beermann F., Martinozzi S., Carreira S., Ackermann J., Kumasaka M., Denat L., Goodall J., Luciani F., Viros A., Demirkan N., Bastian BC, Goding CR, Larue L.: β-catenin induces immortalization of melanocytes by suppressing p16/INK4a expression and cooperates with N-Ras in melanoma development. Gene Dev 21:2923-2935, 2007.
6. Demunter A., Libbrecht L., Degreef H., De Wolf-Peeters C., van den Odrd JJ: Loss of membranous expression of β-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations. Mod Pathol 15:454-461, 2002.
7. Dincer Z., Jasani B., Haywood S.: Metallothionein expression in canine and feline mammary and melanocytic tumours. J Comp Pathol 125:130-136, 2001.
8. Dunn KJ, Williams BO, Li Y., Pavan WJ: Neural crest-directed gene transfer demonstrates Wnt1 role in melanocytes expansion and differentiation during mouse development. Proc Natl Acad Sci U S A 97:10050-10055, 2000.
9. Gross TL, Ihrke PJ, Walder EJ, Affolter VK: Skin Diseases of the Dog and Cat: Clinical and Histopathological Diagnosis, 2nd ed., pp. 813-836. Blackwell Publishing, Oxford, UK, 2005.
10. Hobmayer B., Rentzsch F., Kuhn K., Happel CM, von Laue CC, Snyder P., Rothbächer U., Holstein TW: Wnt signaling molecules act in axis formation in the diploblastic metazoan hydra. Nature 407:186-189, 2000.
11. Ikeya M., Lee SM, Johnson JE, McMahon AP, Takada S.: Wnt signaling required for expansion of neural crest and CNS progenitors. Nature 389:966-970, 1997.
12. Koenig A., Bianco SR, Fosmire S., Wojcieszyn J., Modiano JF: Expression and significance of p53, Rb, p21/waf-1, p16/ink4a, and PTEN tumor suppressors in canine melanoma. Vet Pathol 39:458-472, 2002.
13. Larue L., Beermann F.: Cutaneous melanoma in genetically modified animals. Pigment Cell Res 20:485-497, 2007.
14. Larue L., Delmas V.: The Wnt/β-catenin pathway in melanoma. Front Biosci 11:733-742, 2006.
15. Mayr B., Schaffner G., Reifinger M.: N-ras mutations in canine malignant melanomas. Vet J 165:169-171, 2003.
16. Omholt K., Platz A., Ringborg U., Hansson J.: Cytoplasmic and nuclear accumulation of β-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma. Int J Cancer 92:839-842, 2001.
17. Peifer M., Polakis P.: Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus. Science 287:1606- 1609, 2000.
18. Poutahidis T., Douberis M., Karamanavi E., Angelopoulou K., Koutinas CK, Papazoglou LG: Primary gastric choriocarcinoma in a dog. J Comp Pathol 139:146-150, 2008.
19. Rawlings NG, Simko E., Bebchuk T.: Localization of integrin νβ3 and vascular endothelial growth factor receptor-2 (KDR/ Flk-1) in cutaneous and oral melanomas of dog. Histol Histopathol 18:819-826, 2003.
20. Rothwell TLW, Howlett CR, Middleton DJ, Griffiths DA, Duff BC: Skin neoplasms of dogs in Sydney. Aust Vet J 64:161-164, 1987.
21. Roura S., Miravet S., Piedra J., García de Herreros A., Duñach M.: Regulation of E-cadherin/catenin association by tyrosine phosphorylation. J Biol Chem 274:36734-36740, 1999.
22. Sanders DS, Blessing K., Hassan GA, Bruton R., Marsden JR, Jankowski J.: Alteration in cadherin and catenin expression during the biological progression of melanocytic tumours. Mol Pathol 52:151-157, 1999.
23. Smith SH, Goldschmidt MH, McManus PM: A comparative review of melanocytic neoplasm. Vet Pathol 39:651-678, 2002.
24. van der Loos CM: Multiple immunoenzyme staining: methods and visualizations for the observation with spectral imaging. J Histochem Cytochem 56:313-328, 2008.
25. Wodarz A., Nusse R.: Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59-88, 1998.