pCMV-BMP-2-Transfected Cell-Mediated Gene Therapy in Anterior Cruciate Ligament Reconstruction in Rabbits

Arthroscopy - Journal of Arthroscopic and Related Surgery

Volumn 26, Issue 7, 2010, Pages 968-976

  Wang, Ching Jen ^a   Weng, Lin Hsiu ^a   Hsu, Shan Ling ^a   Sun, Yi Chih ^a   Yang, Ya Ju ^a   Chan, Yi Sheng ^a   Yang, Yu Lin ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CALCIUM ALGINATE; COMPLEMENTARY DNA; CYCLINE; PLASMID VECTOR; VASCULOTROPIN; VIRUS VECTOR; VON WILLEBRAND FACTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE RADIOGRAPHY; BONE TISSUE; CLONING VECTOR; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG SYNTHESIS; GEL; GENETIC TRANSFECTION; GRAFT FAILURE; GRAFT RUPTURE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RABBIT; RAT; RIGIDITY; TENDON; TENDON GRAFT; TENDON GRAFT PULL OUT; TENDON RUPTURE; TENDON TRANSPLANTATION; TENSILE STRENGTH; TIBIA; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WOUND HEALING;

ANIMALS; ANTERIOR CRUCIATE LIGAMENT; BIOMECHANICS; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; BONE TRANSPLANTATION; CELL LINE; CYTOMEGALOVIRUS; GENE THERAPY; HUMANS; KIDNEY; MAGNETIC RESONANCE IMAGING; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOGENESIS; PLASMIDS; PROLIFERATING CELL NUCLEAR ANTIGEN; RABBITS; RATS; RECONSTRUCTIVE SURGICAL PROCEDURES; TENDONS; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VON WILLEBRAND FACTOR; WOUND HEALING;

EID: 77953945232     PISSN: 07498063     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arthro.2009.11.014     Document Type: Article

References (23)

1. Woo S.L., Maynard J., Butler D., et al. Ligament, tendon, and joint capsule insertions to bone. In: Woo S., and Buckwalter J. (Eds). Injury and repair of the musculoskeletal soft tissue (1988), American Academy of Orthopaedic Surgeons, Park Ridge, IL 129-166
2. Arnoczky S.P., Torzilli P.A., Warren R.F., and Allen A.A. Biologic fixation of ligament prosthesis and augmentation. An evaluation of bone ingrowth in the dog. Am J Sports Med 16 (1988) 106-112
3. Forward A.D., and Cowan R.J. Tendon suture to bone. An experimental investigation in rabbits. J Bone Joint Surg Am 45 (1963) 807-823
4. Fujioka H., Thakur R., Wang G.J., Mizuno K., Balian G., and Hurwitz S.R. Comparison of surgically attached and non-attached repair of the rat Achilles tendon-bone interface. Cellular organization and type X collagen expression. Connect Tissue Res 37 (1998) 205-218
5. Kernwein G., Fahey J., and Garrison M. The fate of tendon, fascia and elastic connective tissue transplanted into bone. Ann Surg 108 (1938) 285-290
6. Rodeo S.A., Arnoczky S.P., Torzilli P.A., Hidaka C., and Warren R.F. Tendon-healing in a bone tunnel. J Bone Joint Surg Am 75 (1993) 1795-1803
7. Whiston T.B., and Walmsley R. Some observations on the reactions of bone and tendon after tunnelling of bone and insertion of tendon. J Bone Joint Surg Br 42 (1960) 377-386
8. Bosch U., Kasperczyk W., Reinert C., Oestern H.J., and Tscherne H. Healing at graft fixation site under functional conditions in posterior cruciate ligament reconstruction. A morphological study in sheep. Arch Orthop Trauma Surg 108 (1989) 154-158
9. Bosch U., and Kasperczyk W.J. Healing of the patellar tendon autograft after posterior cruciate ligament reconstruction-A process of ligamentization?. An experimental study in a sheep model. Am J Sports Med 20 (1992) 558-566
10. Hausman M., Bain S., and Ribin C. Reluctance of metaphyseal bone to heal to tendon: Histologic evidence for poor mechanical strength. Trans Orthop Res Soc 14 (1989) 277
11. Lee T.C., Ho J.T., Hung K.S., Chen W.F., Chung Y.H., and Yang Y.L. Bone morphogenetic protein gene therapy using a fibrin scaffold for a rabbit spinal-fusion experiment. Neurosurgery 58 (2006) 373-380
12. Martinek V., Latterman C., Usas A., et al. Enhancement of tendon-bone integration of anterior cruciate ligament grafts with bone morphogenetic protein-2 gene transfer: A histological and biomechanical study. J Bone Joint Surg Am 84 (2002) 1123-1131
13. Reddi A.H. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotechnol 16 (1998) 247-252
14. Riley E.H., Lane J.M., Urist M.R., Lyons K.M., and Lieberman J.R. Bone morphogenetic protein-2: Biology and applications. Clin Orthop Relat Res 324 (1966) 39-46
15. Dubois C., Panicot-Dubois L., Gainor J.F., Furie B.C., and Furie B. Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J Clin Invest 117 (2007) 953-960
16. Fallon A.M., Marzec U.M., Hanson S.R., and Yoganathan A.P. Thrombin formation in vitro in response to shear-induced activation of platelets. Thromb Res 121 (2007) 397-406
17. Heinrich R.A., Vonder Heide E.C., and Climie A.R. Cryofibrinogen formation and inhibition in heparinized plasma. Am J Physiol 204 (1963) 419-422
18. Clarak J., and Stechschulte Jr. D.J. The interface between bone and tendon at an insertion site: A study of the quadriceps tendon insertion. J Anat 192 (1998) 605-616
19. Kohno T., Ishibashi Y., Tsuda E., Kusumi T., Tanaka M., and Toh S. Immunohistochemical demonstration of growth factors at the tendon-bone interface in anterior cruciate ligament reconstruction using a rabbit model. J Orthop Science 12 (2007) 67-73
20. Zysk S.P., Fraunberger P., Veihelmann A., et al. Tunnel enlargement and changes in synovial fluid cytokine profile following anterior cruciate ligament reconstruction with patellar tendon and hamstring tendon grafts. Knee Surg Sports Traumatol Arthrosc 12 (2004) 98-103
21. O'Driscoll S.W., and Salter R.B. The induction of neochondrogenesis in free intra-articular periosteal autografts under the influence of continuous passive motion. An experimental investigation in the rabbits. J Bone Joint Surg Am 66 (1984) 1248-1257
22. Wang C.J., Wang F.S., Yang K.D., Weng L.H., Sun Y.C., and Yang Y.J. The effect of shock wave treatment at the tendon-bone interface-An histomorphological and biomechanical study in rabbits. J Orthop Res 23 (2005) 274-280
23. Rodeo S.A., Suzuki K., Deng X.H., Wozney J., and Warren R.F. Use of recombinant human bone morphogenetic protein-2 to enhance tendon healing in a bone tunnel. Am J Sports Med 27 (1999) 476-488