Vitamin D and fracture prevention

Endocrinology and Metabolism Clinics of North America

Volumn 39, Issue 2, 2010, Pages 347-353

  Bischoff Ferrari, Heike A ^a,b,c  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c TUFTS UNIVERSITY   (United States)

Author keywords

25 Hydroxyvitamin D; Bone density; Falls; Fractures; Supplementation; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; COLECALCIFEROL; PLACEBO; VITAMIN D; VITAMIN D RECEPTOR;

AGE; BONE DENSITY; CALCIUM ABSORPTION; CALCIUM INTAKE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG DOSE COMPARISON; FALL RISK; FALLING; FRACTURE; HIP FRACTURE; HUMAN; LOW DRUG DOSE; MUSCLE FUNCTION; MUSCLE STRENGTH; MUSCLE WEAKNESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; RISK REDUCTION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

25-HYDROXYVITAMIN D 2; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BONE DENSITY; DIETARY SUPPLEMENTS; FEMALE; FRACTURES, BONE; HUMANS; MALE; MICE; MIDDLE AGED; MUSCLE, SKELETAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VITAMIN D; VITAMIN D DEFICIENCY; YOUNG ADULT;

EID: 77953934655     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ecl.2010.02.009     Document Type: Review

References (32)

1. McClung M.R., Geusens P., Miller P.D., et al. Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group. N Engl J Med 2001, 344:333-340.
2. Cummings S.R., Nevitt M.C., Browner W.S., et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 1995, 332:767-773.
3. Centers for Disease Control and Prevention (CDC) Fatalities and injuries from falls among older adults-United States, 1993-2003 and 2001-2005. MMWR Morb Mortal Wkly Rep 2006, 55:1221-1224.
4. Schwartz A.V., Nevitt M.C., Brown B.W., et al. Increased falling as a risk factor for fracture among older women: the study of osteoporotic fractures. Am J Epidemiol 2005, 161:180-185.
5. Cummings S.R., Nevitt M.C. Non-skeletal determinants of fractures: the potential importance of the mechanics of falls. Study of Osteoporotic Fractures Research Group. Osteoporos Int 1994, 4(Suppl 1):67-70.
6. Vellas B.J., Wayne S.J., Romero L.J., et al. Fear of falling and restriction of mobility in elderly fallers. Age Ageing 1997, 26:189-193.
7. Bischoff-Ferrari H.A., Willett W.C., Wong J.B., et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 2009, 169:551-561.
8. Bischoff-Ferrari H.A., Dawson-Hughes B., Staehelin H.B., et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomized controlled trials. BMJ 2009, 339:b3692. 10.1136/bmj.b3692.
9. Glerup H., Mikkelsen K., Poulsen L., et al. Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Calcif Tissue Int 2000, 66:419-424.
10. Schott G.D., Wills M.R. Muscle weakness in osteomalacia. Lancet 1976, 1:626-629.
11. Bischoff-Ferrari H.A., Borchers M., Gudat F., et al. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 2004, 19:265-269.
12. Sorensen O.H., Lund B., Saltin B., et al. Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium. Clin Sci (Lond) 1979, 56:157-161.
13. Bouillon R., Bischoff-Ferrari H., Willett W. Vitamin D and health: perspectives from mice and man. J Bone Miner Res 2008, 23:974-979.
14. Endo I., Inoue D., Mitsui T., et al. Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology 2003, 144:5138-5144.
15. Wicherts I.S., van Schoor N.M., Boeke A.J., et al. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab 2007, 6:6.
16. Bischoff-Ferrari H.A., Dietrich T., Orav E.J., et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged >=60 y. Am J Clin Nutr 2004, 80:752-758.
17. Bischoff H.A., Stahelin H.B., Dick W., et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003, 18:343-351.
18. Pfeifer M., Begerow B., Minne H.W., et al. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 2008, 16:16.
19. Bischoff-Ferrari H.A., Orav E.J., Dawson-Hughes B. Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. Arch Intern Med 2006, 166:424-430.
20. Pfeifer M., Begerow B., Minne H.W., et al. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 2000, 15:1113-1118.
21. Broe K.E., Chen T.C., Weinberg J., et al. A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple-dose study. J Am Geriatr Soc 2007, 55:234-239.
22. Bischoff-Ferrari H.A., Dawson-Hughes B., Willett C.W., et al. Effect of vitamin D on falls: a meta-analysis. JAMA 2004, 291:1999-2006.
23. Bischoff-Ferrari H.A., Dietrich T., Orav E.J., et al. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 2004, 116:634-639.
24. Boonen S., Lips P., Bouillon R., et al. Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 2007, 92(4):1415-1423.
25. Tang B.M., Eslick G.D., Nowson C., et al. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 2007, 370(9588):657-666.
26. Heaney R.P., Barger-Lux M.J., Dowell M.S., et al. Calcium absorptive effects of vitamin D and its major metabolites. J Clin Endocrinol Metab 1997, 82:4111-4116.
27. Giovannucci E., Liu Y., Hollis B.W., et al. 25-Hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 2008, 168:1174-1180.
28. Dobnig H., Pilz S., Scharnagl H., et al. Independent association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality. Arch Intern Med 2008, 168:1340-1349.
29. Steingrimsdottir L., Gunnarsson O., Indridason O.S., et al. Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. JAMA 2005, 294:2336-2341.
30. Bischoff-Ferrari H.A., Kiel D.P., Dawson-Hughes B., et al. Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults. J Bone Miner Res 2009, 24:935-942.
31. Heaney R.P., Dowell M.S., Hale C.A., et al. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 2003, 22:142-146.
32. Heaney R.P. The vitamin D requirement in health and disease. J Steroid Biochem Mol Biol 2005, 15:15.