Interferon-α drives monocyte gene expression in chronic unsuppressed HIV-1 infection

AIDS

Volumn 24, Issue 10, 2010, Pages 1415-1423

  Rempel, Hans ^a   Sun, Bing ^a   Calosing, Cyrus ^a   Pillai, Satish K ^a,b   Pulliam, Lynn ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

gene expression; HIV 1; IFN ; lipopolysaccharide; monocyte

Indexed keywords

ALPHA INTERFERON; CD14 ANTIGEN; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; RNA;

ADULT; AGED; ARTICLE; CHEMOTAXIS; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; IN VITRO STUDY; INFLAMMATION; MALE; MICROARRAY ANALYSIS; MONOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SERODIAGNOSIS; VIRUS LOAD;

ANTIGENS, CD14; CROSS-SECTIONAL STUDIES; FEMALE; GENE EXPRESSION REGULATION; HIV INFECTIONS; HIV-1; HUMANS; IMMUNE TOLERANCE; INTERFERON-ALPHA; MALE; MIDDLE AGED; MONOCYTES; TUMOR NECROSIS FACTOR-ALPHA; UNITED STATES; VIRAL LOAD;

EID: 77953914531     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32833ac623     Document Type: Article

References (37)

1. Douek DC, Roederer M, Koup RA. Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med 2009; 60:471-484.
2. Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12:1365-1371.
3. Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 2001; 13:85-94.
4. Papasavvas E, Pistilli M, Reynolds G, Bucki R, Azzoni L, Chehimi J, et al. Delayed loss of control of plasma lipopoly-saccharide levels after therapy interruption in chronically HIV-1-infected patients. AIDS 2009; 23:369-375.
5. Suffredini AF, Hochstein HD, McMahon FG. Dose-related inflammatory effects of intravenous endotoxin in humans: evaluation of a new clinical lot of Escherichia coli O:113 endotoxin. J Infect Dis 1999; 179:1278-1282.
6. Herbeuval JP, Shearer GM. HIV-1 immunopathogenesis: how good interferon turns bad. Clin Immunol 2007; 123:121-128.
7. von Sydow M, Sonnerborg A, Gaines H, Strannegard O. Inter-feron-alpha and tumor necrosis factor-alpha in serum of patients in various stages of HIV-1 infection. AIDS Res Hum Retroviruses 1991; 7:375-380.
8. Khatissian E, Tovey MG, Cumont MC, Monceaux V, Lebon P, Montagnier L, et al. The relationship between the interferon alpha response and viral burden in primary SIV infection. AIDS Res Hum Retroviruses 1996; 12:1273-1278.
9. Tilton JC, Johnson AJ, Luskin MR, Manion MM, Yang J, Adelsberger JW, et al. Diminished production of monocyte proinflammatory cytokines during human immunodeficiency virus viremia is mediated by type I interferons. J Virol 2006; 80:11486-11497.
10. Lane HC, Davey V, Kovacs JA, Feinberg J, Metcalf JA, Herpin B, et al. Interferon-alpha in patients with asymptomatic human immunodeficiency virus (HIV) infection. A randomized, placebo-controlled trial. Ann Intern Med 1990; 112:805-811.
11. Rodriguez B, Lederman MM, Jiang W, Bazdar DA, Garate K, Harding CV, et al. Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection. AIDS 2006; 20:1379-1389.
12. Sedaghat AR, German J, Teslovich TM, Cofrancesco J Jr, Jie CC, Talbot CC Jr, et al. Chronic CD4R T-cell activation and depletion in human immunodeficiency virus type 1 infection: type I interferon-mediated disruption of T-cell dynamics. J Virol 2008; 82:1870-1883.
13. Francis ML, Meltzer MS, Gendelman HE. Interferons in the persistence, pathogenesis, and treatment of HIV infection. AIDS Res Hum Retroviruses 1992; 8:199-207.
14. Zagury D, Lecoq H, Gervi I, Le Buanec H, Zagury JF, Bizzini B, et al. Anti-IFN alpha immunization raises the IFN alpha-neutralizing capacity of serum: an adjuvant to antiretroviral tritherapy. Biomed Pharmacother 1999; 53:90-92.
15. Gringeri A, Musicco M, Hermans P, Bentwich Z, Cusini M, Bergamasco A, et al. Active antiinterferon-alpha immunization: a European-Israeli, randomized, double-blind, placebo-controlled clinical trial in 242 HIV-1: infected patients (the EURIS study). J Acquir Immune Defic Syndr Hum Retrovirol 1999; 20:358-370.
16. Ancuta P, Kamat A, Kunstman KJ, Kim EY, Autissier P, Wurcel A, et al. Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. PLoS ONE 2008; 3:e2516.
17. Sonza S, Maerz A, Deacon N, Meanger J, Mills J, Crowe S. Human immunodeficiency virus type 1 replication is blocked prior to reverse transcription and integration in freshly isolated peripheral blood monocytes. J Virol 1996; 70:3863-3869.
18. Pulliam L, Sun B, Rempel H. Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load. J Neuroimmunol 2004; 157:93-98.
19. Schroeder A, Mueller O, Stocker S, Salowsky R, Leiber M, Gassmann M, et al. The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol 2006; 7:3.
20. Ihaka R, Gentleman R. R: A Language for Data Analysis and Graphics. J Comput Graph Stat 1996; 5:299-314.
21. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004; 5:R80.
22. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc Series B (Methodological) 1995; 57:125-133.
23. Gregson JN, Steel A, Bower M, Gazzard BG, Gotch FM, Good-ier MR. Elevated plasma lipopolysaccharide is not sufficient to drive natural killer cell activation in HIV-1-infected individuals. AIDS 2009; 23:29-34.
24. Goodall JC, Ellis L, Yeo GS, Gaston JS. Does HLA-B27 influence the monocyte inflammatory response to lipopolysaccharide? Rheumatology (Oxford) 2007; 46:232-237.
25. Stylianou E, Aukrust P, Bendtzen K, Muller F, Froland SS. Interferons and interferon (IFN)-inducible protein 10 during highly active antiretroviral therapy (HAART)-possible immu-nosuppressive role of IFN-alpha in HIV infection. Clin Exp Immunol 2000; 119:479-485.
26. Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat Immunol 2004; 5:1219-1226.
27. Zhang Z, Wang FS. Plasmacytoid dendritic cells act as the most competent cell type in linking antiviral innate and adaptive immune responses. Cell Mol Immunol 2005; 2:411-417.
28. LehmannC,Harper JM, TaubertD, HartmannP, Fatkenheuer G, Jung N, et al. Increased interferon alpha expression in circulating plasmacytoid dendritic cells of HIV-1-infected patients. J Acquir Immune Defic Syndr 2008; 48:522-530.
29. Kadowaki N, Antonenko S, Lau JY, Liu YJ. Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med 2000; 192:219-226.
30. Soumelis V, Scott I, Gheyas F, Bouhour D, Cozon G, Cotte L, et al. Depletion of circulating natural type 1 interferon-produ-cing cells in HIV-infected AIDS patients. Blood 2001; 98:906-912.
31. Malleret B, Maneglier B, Karlsson I, Lebon P, Nascimbeni M, Perie L, et al. Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression. Blood 2008; 112:4598-4608.
32. Hardy GA, Sieg SF, Rodriguez B, Jiang W, Asaad R, Lederman MM, et al. Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression. Blood 2009; 113:5497-5505.
33. Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman GJ, et al. CD4R T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004; 200:749-759.
34. Fujihara M, Muroi M, Tanamoto K, Suzuki T, Azuma H, Ikeda H. Molecular mechanisms of macrophage activation and deacti-vation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther 2003; 100:171-194.
35. Rempel H, Calosing C, Sun B, Pulliam L. Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infec-tivity. PLoS ONE 2008; 3:e1967.
36. van der Kuyl AC, van den Burg R, Zorgdrager F, Groot F, Berkhout B, Cornelissen M. Sialoadhesin in (CD169) expression in CD14R cells is upregulated early after HIV-1 infection and increases during disease progression. PLoS ONE 2007; 2:e257.
37. Crocker PR, Mucklow S, Bouckson V, McWilliam A, Willis AC, Gordon S, et al. Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains. EMBO J 1994; 13:4490-4503.