Cardiovascular responses to l-glutamate microinjection into the hypothalamic paraventricular nucleus are mediated by a local nitric oxide-guanylate cyclase mechanism

Brain Research

Volumn 1344, Issue , 2010, Pages 87-95

  Busnardo, Cristiane ^a   Crestani, Carlos C ^a   Tavares, Rodrigo F ^a   Resstel, Leonardo B M ^a   Correa, Fernando M A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Blood pressure and heart rate; Carboxy PTIO; Hypothalamus; N Propyl l arginine; Nitric oxide; ODQ; PVN

Indexed keywords

GLUTAMIC ACID; GUANYLATE CYCLASE; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; HEART RATE; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TACHYCARDIA;

ANIMALS; BENZOATES; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; DRUG INTERACTIONS; GLUTAMIC ACID; GUANYLATE CYCLASE; HEART RATE; IMIDAZOLES; MALE; MICROINJECTIONS; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROPRUSSIDE; OXADIAZOLES; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; QUINOXALINES; RATS; RATS, WISTAR; TIME FACTORS; WAKEFULNESS;

RATTUS;

EID: 77953913956     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.05.023     Document Type: Article

References (38)

1. Alves F., Crestani C., Resstel L., and Correa F. Bed nucleus of the stria terminalis NMDA receptors and nitric oxide modulate baroreflex cardiac component in unanesthetized rats. J. Neurosci. Res. 87 7 (2009) 1703-1711
2. Badoer E. Cardiovascular role of parvocellular neurons in the paraventricular nucleus of the hypothalamus. News Physiol. Sci. 11 (1996) 43-47
3. Bains J.S., and Ferguson A.V. Nitric oxide depolarizes type II paraventricular nucleus neurons in vitro. Neuroscience 79 (1997) 149-159
4. Brenman J.E., and Bredt D.S. Synaptic signaling by nitric oxide. Curr. Opin. Neurobiol. 7 (1997) 374-378
5. Busnardo C., Tavares R.F., and Correa F.M.A. Role of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors in the cardiovascular effects of L-glutamate microinjection into the hypothalamic paraventricular nucleus of unanesthetized rats. J. Neurosci. Res. 87 9 (2009) 2066-2077
6. Cunningham Jr. E.T., and Sawchenko P.E. Reflex control of magnocellular vasopressin and oxytocin secretion. Trends Neurosci. 14 (1991) 406-411
7. Dampney R.A. Functional organization of central pathways regulating the cardiovascular system. Physiol. Rev. 74 (1994) 323-364
8. Garthwaite J. Concepts of neural nitric oxide-mediated transmission. Eur. J. Neurosci. 27 (2008) 2783-2802
9. Garthwaite J., and Boulton C.L. Nitric oxide signaling in the central nervous system. Annu. Rev. Physiol. 57 (1995) 683-706
10. Garthwaite J., Charles S.L., and Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336 (1988) 385-388
11. Griffith O.W., and Stuehr D.J. Nitric oxide synthases: properties and catalytic mechanism. Annu. Rev. Physiol. 57 (1995) 707-736
12. Hara K., and Harris R.A. The anesthetic mechanism of urethane: the effects on neurotransmitter-gated ion channels. Anesth. Analg. 94 (2002) 313-318 table of contents
13. Hill-Venning C., Belelli D., Peters J.A., and Lambert J.J. Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor. Br. J. Pharmacol. 120 (1997) 749-756
14. Horn T., Smith P.M., McLaughlin B.E., Bauce L., Marks G.S., Pittman Q.J., and Ferguson A.V. Nitric oxide actions in paraventricular nucleus: cardiovascular and neurochemical implications. Am. J. Physiol. 266 (1994) R306-R313
15. Kiedrowski L., Costa E., and Wroblewski J.T. Glutamate receptor agonists stimulate nitric oxide synthase in primary cultures of cerebellar granule cells. J. Neurochem. 58 (1992) 335-341
16. Krasowski M.D., and Harrison N.L. General anaesthetic actions on ligand-gated ion channels. Cell. Mol. Life Sci. 55 (1999) 1278-1303
17. Li Y.F., Mayhan W.G., and Patel K.P. NMDA-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide. Am. J. Physiol. Heart Circ. Physiol. 281 (2001) H2328-H2336
18. MacDermott A.B., Mayer M.L., Westbrook G.L., Smith S.J., and Barker J.L. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321 (1986) 519-522
19. Martin D.S., Segura T., and Haywood J.R. Cardiovascular responses to bicuculline in the paraventricular nucleus of the rat. Hypertension 18 (1991) 48-55
20. Martins-Pinge M.C., Garcia M.R., Zoccal D.B., Crestani C.C., and Pinge-Filho P. Differential influence of iNOS and nNOS inhibitors on rostral ventrolateral medullary mediated cardiovascular control in conscious rats. Auton. Neurosci. 131 (2007) 65-69
21. Meeker R.B., Greenwood R.S., and Hayward J.N. Glutamate receptors in the rat hypothalamus and pituitary. Endocrinology 134 (1994) 621-629
22. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. 2 ed (1986), Harcourt Brace Jovanovich, Sidney
23. Prast H., and Philippu A. Nitric oxide as modulator of neuronal function. Prog. Neurobiol. 64 (2001) 51-68
24. Pyner S., Cleary J., Buchan P.M., and Coote J.H. Tracing functionally identified neurones in a multisynaptic pathway in the hamster and rat using herpes simplex virus expressing green fluorescent protein. Exp. Physiol. 86 (2001) 695-702
25. Ranson R.N., Motawei K., Pyner S., and Coote J.H. The paraventricular nucleus of the hypothalamus sends efferents to the spinal cord of the rat that closely appose sympathetic preganglionic neurones projecting to the stellate ganglion. Exp. Brain Res. 120 (1998) 164-172
26. Resstel L.B., and Correa F.M. Injection of l-glutamate into medial prefrontal cortex induces cardiovascular responses through NMDA receptor - nitric oxide in rat. Neuropharmacology 51 (2006) 160-167
27. Sanna E., Mascia M.P., Klein R.L., Whiting P.J., Biggio G., and Harris R.A. Actions of the general anesthetic propofol on recombinant human GABAA receptors: influence of receptor subunits. J. Pharmacol. Exp. Ther. 274 (1995) 353-360
28. Shafton A.D., Ryan A., and Badoer E. Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat. Brain Res. 801 (1998) 239-243
29. Smolenski A., Burkhardt A.M., Eigenthaler M., Butt E., Gambaryan S., Lohmann S.M., and Walter U. Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch. Pharmacol. 358 (1998) 134-139
30. Stern J.E., Li Y., and Zhang W. Nitric oxide: a local signalling molecule controlling the activity of pre-autonomic neurones in the paraventricular nucleus of the hypothalamus. Acta Physiol. Scand. 177 (2003) 37-42
31. Swanson L.W., and Kuypers H.G. The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. J. Comp. Neurol. 194 (1980) 555-570
32. Swanson L.W., and Sawchenko P.E. Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms. Neuroendocrinology 31 (1980) 410-417
33. Tavares R.F., Resstel L.B., and Correa F.M. Interaction between glutamatergic and nitrergic mechanisms mediating cardiovascular responses to L-glutamate injection in the diagonal band of Broca in anesthetized rats. Life Sci. 81 (2007) 855-862
34. Wang X., and Robinson P.J. Cyclic GMP-dependent protein kinase and cellular signaling in the nervous system. J. Neurochem. 68 (1997) 443-456
35. Wang Y., Liu X.F., Cornish K.G., Zucker I.H., and Patel K.P. Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure. Am. J. Physiol. Heart Circ. Physiol. 288 (2005) H205-H213
36. Wood P.L., Emmett M.R., Rao T.S., Cler J., Mick S., and Iyengar S. Inhibition of nitric oxide synthase blocks N-methyl-D-aspartate-, quisqualate-, kainate-, harmaline-, and pentylenetetrazole-dependent increases in cerebellar cyclic GMP in vivo. J. Neurochem. 55 (1990) 346-348
37. Zhang K., and Patel K.P. Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: role of GABA. Am. J. Physiol. 275 (1998) R728-R734
38. Zhang K., Mayhan W.G., and Patel K.P. Nitric oxide within the paraventricular nucleus mediates changes in renal sympathetic nerve activity. Am. J. Physiol. 273 (1997) R864-R872