Low-frequency therapeutic ultrasound with varied duty cycle: Effects on the ischemic brain and the inner ear

Ultrasound in Medicine and Biology

Volumn 36, Issue 7, 2010, Pages 1188-1195

  Reuter, Peter ^a   Masomi, Julia ^b   Kuntze, Holger ^b   Fischer, Ilka ^b   Helling, Kai ^b   Sommer, Clemens ^b   Alessandri, Beat ^b   Heimann, Axel ^b   Gerriets, Tibo ^a   Marx, Juergen ^b   Kempski, Oliver ^b   Nedelmann, Max ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Duty cycle; Rat model; Safety; Sonothrombolysis; Stroke

Indexed keywords

ACUTE STROKE; ADVERSE EFFECT; AUDITORY SYSTEMS; CONTINUOUS WAVES; DUTY CYCLES; EVOKED POTENTIALS; HIGH RATE; IN-LINE; IN-VITRO; INNER EAR; INSONATION; LOW FREQUENCY; MIDDLE CEREBRAL ARTERY; PARAMETER SETTING; PULSED PARAMETERS; RAT MODEL; SAFETY ISSUES; SIDE EFFECT; SONOTHROMBOLYSIS; SUBARACHNOID HEMORRHAGES; THERAPEUTIC ULTRASOUND; TRANSCRANIAL;

ANIMALS; AUDITION; ELECTROPHYSIOLOGY; ULTRASONICS;

RATS;

ALTEPLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CONTINUOUS INFUSION; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; EVOKED AUDITORY RESPONSE; HEARING IMPAIRMENT; HISTOPATHOLOGY; LOW FREQUENCY THERAPEUTIC ULTRASOUND; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MORTALITY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT; SAFETY; ULTRASOUND THERAPY;

ANIMALS; AUDITORY THRESHOLD; BRAIN ISCHEMIA; EAR, INNER; HEARING DISORDERS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; RATS; RATS, WISTAR; ULTRASONIC THERAPY;

EID: 77953895323     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2010.04.013     Document Type: Article

References (21)

1. Alexandrov A.V., Molina C.A., Grotta J.C., Garami Z., Ford S.R., Alvarez-Sabin J., Montaner J., Saqqur M., Demchuk A.M., Moye L.A., Hill M.D., Wojner A.W. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med 2004, 351:2170-2178.
2. Ammi A.Y., Mast T.D., Huang I.H., Abruzzo T.A., Coussios C.C., Shaw G.J., Holland C.K. Characterization of ultrasound propagation through ex vivo human temporal bone. Ultrasound Med Biol 2008, 34:1578-1589.
3. Behrens S., Spengos K., Daffertshofer M., Schroeck H., Dempfle C.E., Hennerici M. Transcranial ultrasound-improved thrombolysis: Diagnostic vs. therapeutic ultrasound. Ultrasound Med Biol 2001, 27:1683-1689.
4. Daffertshofer M., Hennerici M. Sonothrombolysis: Experimental evidence. Front Neurol Neurosci 2006, 21:140-149.
5. Daffertshofer M., Gass A., Ringleb P., Sitzer M., Sliwka U., Els T., Sedlaczek O., Koroshetz W.J., Hennerici M.G. Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: Increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: Results of a phase II clinical trial. Stroke 2005, 36:1441-1446.
6. Datta S., Coussios C.C., Ammi A.Y., Mast T.D., de Courten-Myers G.M., Holland C.K. Ultrasound-enhanced thrombolysis using Definity as a cavitation nucleation agent. Ultrasound Med Biol 2008, 34:1421-1433.
7. Eggers J., Konig I.R., Koch B., Handler G., Seidel G. Sonothrombolysis with transcranial color-coded sonography and recombinant tissue-type plasminogen activator in acute middle cerebral artery main stem occlusion: Results from a randomized study. Stroke 2008, 39:1470-1475.
8. Evans J.A., Tavakoli M.B. Ultrasonic attenuation and velocity in bone. Phys Med Biol 1990, 35:1387-1396.
9. Fry F.J., Barger J.E. Acoustical properties of the human skull. J Acoust Soc Am 1978, 63:1576-1590.
10. Heinrich U.R., Fischer I., Brieger J., Rumelin A., Schmidtmann I., Li H., Mann W.J., Helling K. Ascorbic acid reduces noise-induced nitric oxide production in the guinea pig ear. Laryngoscope 2008, 118:837-842.
11. Ishibashi T., Akiyama M., Onoue H., Abe T., Furuhata H. Can transcranial ultrasonication increase recanalization flow with tissue plasminogen activator?. Stroke 2002, 33:1399-1404.
12. Joshi C.N., Jain S.K., Murthy P.S. An optimized triphenyltetrazolium chloride method for identification of cerebral infarcts. Brain Res Brain Res Protoc 2004, 13:11-17.
13. Meunier J.M., Holland C.K., Lindsell C.J., Shaw G.J. Duty cycle dependence of ultrasound enhanced thrombolysis in a human clot model. Ultrasound Med Biol 2007, 33:576-583.
14. Myers M.R. Transient temperature rise due to ultrasound absorption at a bone/soft-tissue interface. J Acoust Soc Am 2004, 115:2887-2891.
15. Nedelmann M., Eicke B.M., Lierke E.G., Heimann A., Kempski O., Hopf H.C. Low-frequency ultrasound induces nonenzymatic thrombolysis in vitro. J Ultrasound Med 2002, 21:649-656.
16. Nedelmann M., Brandt C., Schneider F., Eicke B.M., Kempski O., Krummenauer F., Dieterich M. Ultrasound-induced blood clot dissolution without a thrombolytic drug is more effective with lower frequencies. Cerebrovasc Dis 2005, 20:18-22.
17. Nedelmann M., Stolz E., Gerriets T., Baumgartner R.W., Malferrari G., Seidel G., Kaps M. Consensus recommendations for transcranial color-coded Duplex sonography for the assessment of intracranial arteries in clinical trials on acute stroke. Stroke 2009, 40:3238-3244.
18. Nedelmann M., Wilhelm-Schwenkmezger T., Alessandri B., Heimann A., Schneider F., Eicke B.M., Dieterich M., Kempski O. Cerebral embolic ischemia in rats: Correlation of stroke severity and functional deficit as important outcome parameter. Brain Res 2007, 1130:188-196.
19. Nedelmann M., Reuter P., Walberer M., Sommer C., Alessandri B., Schiel D., Ritschel N., Kempski O., Kaps M., Mueller C., Bachmann G., Gerriets T. Detrimental effects of 60 kHz sonothrombolysis in rats with middle cerebral artery occlusion. Ultrasound Med Biol 2008, 34:2019-2027.
20. Suchkova V., Carstensen E.L., Francis C.W. Ultrasound enhancement of fibrinolysis at frequencies of 27 to 100 kHz. Ultrasound Med Biol 2002, 28:377-382.
21. Wilhelm-Schwenkmezger T., Pittermann P., Zajonz K., Kempski O., Dieterich M., Nedelmann M. Therapeutic application of 20-kHz transcranial ultrasound in an embolic middle cerebral artery occlusion model in rats: Safety concerns. Stroke 2007, 38:1031-1035.