Therapeutic application of 20-kHz transcranial ultrasound in an embolic middle cerebral artery occlusion model in rats: Safety concerns

Stroke

Volumn 38, Issue 3, 2007, Pages 1031-1035

  Wilhelm Schwenkmezger, Thomas ^a   Pittermann, Patrick ^a   Zajonz, Katharina ^a   Kempski, Oliver ^a   Dieterich, Marianne ^a   Nedelmann, Max ^b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Efficacy; Safety; Stroke; Thrombolysis; Ultrasound

Indexed keywords

ALTEPLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN EMBOLISM; BRAIN INFARCTION; BRAIN INFARCTION SIZE; CAUSE OF DEATH; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; FIBRINOLYTIC THERAPY; FOLLOW UP; HISTOLOGY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC EXAMINATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECANALIZATION; SAFETY; SUBARACHNOID HEMORRHAGE; THERAPY EFFECT; ANIMAL; CEREBRAL ARTERY DISEASE; COMPARATIVE STUDY; DISEASE MODEL; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; ULTRASOUND THERAPY; WISTAR RAT;

ANIMALS; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; RATS; RATS, WISTAR; ULTRASONIC THERAPY;

EID: 33947525764     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000257966.32242.0b     Document Type: Article

References (22)

1. Mori E, Yoneda Y, Tabuchi M. Intravenous recombinant tissue plasminogen activator in acute carotid artery territory stroke. Neurology. 1992;42:976-982.
2. The ATLANTIS, ECASS, and NINDS rt-PA Study Group Investigators. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet. 2004;363:768-774.
3. Daffertshofer M, Hennerici MG. Ultrasound in the treatment of ischemic stroke. Lancet Neurol. 2003;2:283-290.
4. Alexandrov AV, Molina CA, Grotta JC, Garami Z, Ford SR, Alvarez-Sabin J, Montaner J, Saqqur M, Demchuk AM, Moyé LA, Hill MD, Wojner AW. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med. 2004;351:2170-2178.
5. Eggers J, Koch B, Meyer K, König I, Seidel G. Effect of ultrasound on thrombolysis of middle cerebral artery occlusion. Ann Neurol. 2003;53:797-800.
6. Molina CA, Ribo M, Rubiera M, Montaner J, Santamarina E, Delgado-Mederos R, Arenillas JF, Huertas R, Purroy F, Delgado P, Alvarez-Sabin J. Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke. 2006;37:425-429.
7. Ishibashi T, Akiyama M, Onoue H, Abe T, Furuhata H. Can transcranial ultrasonication increase recanalization flow with tissue plasminogen activator? Stroke. 2002;33:1399-1404.
8. Nedelmann M, Eicke BM, Lierke EG, Heimann A, Kempski O, Hopf HC. Low-frequency ultrasound induces nonenzymatic thrombolysis in vitro. J Ultrasound Med. 2002;21:649-656.
9. Suchkova VN, Baggs RB, Francis CW. Effect of 40-kHz ultrasound on acute thrombotic ischemia in a rabbit femoral artery thrombosis model. Circulation. 2000;101:2296-2301.
10. Suchkova V, Carstensen EL, Francis CW. Ultrasound enhancement of fibrinolysis at frequencies of 27 to 100 kHz. Ultrasound Med Biol. 2002;28:377-382.
11. Behrens S, Spengos K, Daffertshofer M, Schroeck H, Dempfle CE, Hennerici M. Transcranial ultrasound-improved thrombolysis: diagnostic vs. therapeutic ultrasound. Ultrasound Med Biol. 2001;27:1683-1689.
12. Nedelmann M, Brandt C, Schneider F, Eicke BM, Kempski O, Krummenauer F, Dieterich M. Ultrasound-induced blood clot dissolution without a thrombolytic drug is more effective with lower frequencies. Cerebrovasc Dis. 2005;20:18-22.
13. Daffertshofer M, Huang Z, Fatar M, Popolo M, Schroeck H, Kuschinsky W, Moskowitz MA, Hennerici MG. Efficacy of sonothrombolysis in a rat model of embolic ischemic stroke. Neurosci Lett. 2004;361:115-119.
14. Daffertshofer M, Gass A, Ringleb P, Sitzer M, Sliwka U, Els T, Sedlaczek O, Koroshetz WJ, Hennerici MG. Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia. Stroke. 2005;36:1441-1446.
15. Schneider F, Gerriets T, Walberer M, Mueller C, Rolke R, Eicke BM, Bohl J, Kempski O, Kaps M, Bachmann G, Dieterich M, Nedelmann M. Brain edema and intracerebral necrosis caused by transcranial low-frequency 20 kHz ultrasound: a safety study in rats. Stroke. 2006;37:1301-1306.
16. Zhang RL, Chopp M, Zhang ZG, Jiang Q, Ewing JR. A rat model of focal embolic cerebral ischemia. Brain Res. 1997;766:83-92.
17. Brambrink AM, Kopacz L, Astheimer A, Noga H, Heimann A, Kempski O. Control of brain temperature during experimental global ischaemia in rats. J Neurosci Methods. 1999;15:92:111-122.
18. Schueler OG, Plesnila N, Otto D, Baethmann AJ, Back T. Early thrombolysis inhibits peri-infarct depolarizations in embolic MCA occlusion. Neuroreport. 2001;12:3943-3946.
19. Reinhard M, Hetzel A, Krueger S, Kretzer S, Talazko J, Ziyeh S, Weber J, Els T. Blood-brain barrier disruption by low-frequency ultrasound. Stroke. 2006;37:1546-1548.
20. Fatar M, Stroick M, Griebe M, Alonso A, Hennerici M, Daffertshofer M. Brain temperature during 340-kHz pulsed ultrasound insonation: a safety study for sonothrombolysis. Stroke. 2006;37:1883-1887.
21. Schmid-Elsaesser R, Zausinger S, Hungerhuber E, Baethmann A, Reulen HJ. A critical reevaluation of the intraluminal thread model of focal cerebral ischemia. Stroke. 1998;29:2162-2170.
22. Krueger K, Busch E. Protocol of a thromboembolic stroke model in the rat: review of the experimental procedure and comparison of models. Invest Radiol. 2002;37:600-608.