Age-related changes in P2 odorant receptor mapping in the olfactory bulb

Chemical Senses

Volumn 35, Issue 5, 2010, Pages 417-426

  Costanzo, Richard M ^a   Kobayashi, Masayoshi ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Aging; Glomeruli; Olfactory bulb; Olfactory discrimination; Receptor mapping

Indexed keywords

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; MALE; MEASUREMENT; MOUSE; NERVE FIBER; NONHUMAN; OLFACTORY BULB; OLFACTORY DISCRIMINATION; OLFACTORY RECEPTOR; PRIORITY JOURNAL; SMELLING;

AGED; ANIMALS; BRAIN MAPPING; FEMALE; HUMANS; MALE; MICE; MICE, TRANSGENIC; ODORS; OLFACTORY BULB; OLFACTORY RECEPTOR NEURONS; RECEPTORS, ODORANT;

MUS;

EID: 77953880797     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjq029     Document Type: Article

References (22)

1. Cain WS, Stevens JC. 1989. Uniformity of olfactory loss in aging. Ann N Y Acad Sci. 561:29-38.
2. Chehrehasa F, Key B, St John JA. 2007. The shape of the olfactory bulb influences axon targeting. Brain Res. 1169:17-23.
3. Conley DB, Robinson AM, Shinners MJ, Kern RC. 2003. Age-related olfactory dysfunction: cellular and molecular characterization in the rat. Am J Rhinol. 17:169-175.
4. Cutforth T, Moring L, Mendelsohn M, Nemes A, Shah NM, Kim MM, Frisen J, Axel R. 2003. Axonal ephrin-As and odorant receptors: coordinate determination of the olfactory sensory map. Cell. 114: 311-322.
5. Doty RL, Shaman P, Applebaum SL, Giberson R, Siksorski L, Rosenberg L. 1984. Smell identification ability: changes with age. Science. 226: 1441-1443.
6. Elsner RJ. 2001a. Environment and medication use influence olfactory abilities of older adults. J Nutr Health Aging. 5:5-10.
7. Elsner RJ. 2001b. Odor threshold, recognition, discrimination and identification in centenarians. Arch Gerontol Geriatr. 33: 81-94.
8. Hinds JW, McNelly NA. 1981. Aging in the rat olfactory system: correlation of changes in the olfactory epithelium and olfactory bulb. J Comp Neurol. 203:441-453.
9. Johnson BA, Leon M. 2000. Modular representations of odorants in the glomerular layer of the rat olfactory bulb and the effects of stimulus concentration. J Comp Neurol. 422:496-509.
10. Lee AC, Tian H, Grosmaitre X, Ma M. 2009. Expression patterns of odorant receptors and response properties of olfactory sensory neurons in aged mice. Chem Senses. 34:695-703.
11. Meisami E, Mikhail L, Baim D, Bhatnagar KP. 1998. Human olfactory bulb: aging of glomeruli and mitral cells and a search for the accessory olfactory bulb. Ann N Y Acad Sci. 855:708-715.
12. Mombaerts P, Wang F, Dulac C, Chao SK, Nemes A, Mendelsohn M, Edmondson J, Axel R. 1996. Visualizing an olfactory sensory map. Cell. 87:675-686.
13. Murphy C, Schubert CR, Cruickshanks KJ, Klein BE, Klein R, Nondahl DM. 2002. Prevalence of olfactory impairment in older adults. JAMA. 288: 2307-2312.
14. Rawson NE. 2006. Olfactory loss in aging. Sci Aging Knowledge Environ. 2006:e6.
15. Ressler KJ, Sullivan SL, Buck LB. 1994. Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell. 79:1245-1255.
16. Royal SJ, Key B. 1999. Development of P2 olfactory glomeruli in P2- internal ribosome entry site-tau-LacZ transgenic mice. J Neurosci. 19: 9856-9864.
17. Salcedo E, Zhang C, Kronberg E, Restrepo D. 2005. Analysis of training- induced changes in ethyl acetate odor maps using a new computational tool to map the glomerular layer of the olfactory bulb. Chem Senses. 30:615-626.
18. R.M. Costanzo and M. Kobayashi Schaefer ML, Finger TE, Restrepo D. 2001. Variability of position of the P2 glomerulus within a map of the mouse olfactory bulb. J Comp Neurol. 436:351-362.
19. Schwarting G.A., Raitcheva D., Crandall J.E., Burkhardt C., Puschel A.W. 2004. Semaphorin 3A-mediated axon guidance regulates convergence and targeting of P2 odorant receptor axons. Eur J Neurosci. 19: 1800-1810.
20. Stevens JC, Cain WS. 1987. Old-age deficits in the sense of smell as gauged by thresholds, magnitude matching, and odor identification. Psychol Aging. 2:36-42.
21. Sullivan SL, Ressler KJ, Buck LB. 1995. Spatial patterning and information coding in the olfactory system. Curr Opin Genet Dev. 5:516-523.
22. Weiler E, Farbman AI. 1998. Proliferation decrease in the olfactory epithelium during postnatal development. Ann N Y Acad Sci. 855:230-234.