Synthesis and anti-HIV activity of 2′-deoxy-2′-fluoro-4′-C-ethynyl nucleoside analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 14, 2010, Pages 4053-4056

  Wang, Qiang ^a   Li, Yanfeng ^a   Song, Chuanjun ^a   Qian, Keduo ^b   Chen, Chin Ho ^c   Lee, Kuo Hsiung ^b   Chang, Junbiao ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b UNC Hamner Institute for Drug Safety Sciences   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

2 Deoxy 2 fluoro 4 C ethynyl nucleosides; Anti HIV activity

Indexed keywords

1 (2' DEOXY 2' FLUORO 4' C ETHYNYL BETA DEXTRO ARABINOFURANOSYL)CYTOSINE; 1 (2' DEOXY 2' FLUORO 4' C ETHYNYL BETA DEXTRO ARABINOFURANOSYL)THYMINE; 1 (2' DEOXY 2' FLUORO 4' C ETHYNYL BETA DEXTRO ARABINOFURANOSYL)URACIL; ANTIVIRUS AGENT; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; NONHUMAN; VIRUS REPLICATION; VIRUS STRAIN; WILD TYPE;

ANTI-HIV AGENTS; CELL LINE; DEOXYRIBONUCLEOSIDES; HIV-1; HUMANS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77953873094     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.05.090     Document Type: Article

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