Neurobehavioral effects of acute exposure to aromatic hydrocarbons

International Journal of Toxicology

Volumn 29, Issue 3, 2010, Pages 277-290

  McKee, Richard H ^a   Lammers, J H C M ^b   Muijser, H ^b   Owen, D E ^c   Kulig, B M ^b  

^a EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

^b TNO   (Netherlands)

^c Shell Chemicals Ltd   (United Kingdom)

Author keywords

Aromatic hydrocarbon; Central nervous system depression; Neurotoxicology; Occupational exposure limits; Trimethyl benzene

Indexed keywords

1,2,4 TRIMETHYLBENZENE; ALKYL GROUP; AROMATIC HYDROCARBON; CARBON 11;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DEPRESSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GAIT; MALE; MOLECULAR WEIGHT; MOTOR ACTIVITY; NEUROTOXICITY; NEUROTOXICOLOGY; NONHUMAN; OCCUPATIONAL EXPOSURE; RAT; VISUAL DISCRIMINATION;

ANIMALS; AROUSAL; BENZENE DERIVATIVES; BODY TEMPERATURE REGULATION; BODY WEIGHT; BRAIN; CENTRAL NERVOUS SYSTEM; CONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GAIT; HYDROCARBONS, AROMATIC; INHALATION EXPOSURE; MALE; MOTOR ACTIVITY; NEUROMUSCULAR AGENTS; RANDOM ALLOCATION; RATS; RATS, WISTAR; RESPIRATORY SYSTEM; SOLVENTS; TIME FACTORS; VISUAL PERCEPTION;

EID: 77953865946     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581810365089     Document Type: Article

References (37)

1. McKee R., Lammers J., Hoogendijk E., et al. Model studies for evaluating the acute neurobehavioral effects of complex hydrocarbon solvents. I. Validation of methods with ethanol. Neurotoxicology. 2006 ; 27 (6). 1064-1079.
2. Lammers J., Emmen H., Muijser H., et al. Model studies for evaluating the acute neurobehavioral effects of complex hydrocarbon solvents. II. Neurobehavioral effects of white spirit in rat and human. Neurotoxicology. 2007 ; 28 (4). 736-750. (Pubitemid 47058573)
3. Hissink A., Krüse J., Kulig B., et al. Model studies for evaluating the acute neurobehavioral effects of complex hydrocarbon solvents III. PBPK modeling of white spirit constituents as a tool for integrating animal and human test data. Neurotoxicology. 2007 ; 28 (4). 751-760.
4. Lammers J., Emmen H., Muijser H., et al. Neurobehavioral effects of cyclohexane in rat and human. Int J Toxicol. 2009 ; 28 (6). 488-497.
5. Hissink A., Kulig B., Kruse J., et al. Physiologically based pharmacokinetic modeling of cyclohexane as a tool for integrating animal and human test data. Int J Toxicol. 2009 ; 28 (6). 498-509.
6. Ridgway P., Nixon T., Leach J. -P. Occupational exposure to organic solvents and long-term nervous system damage detectable by brain imaging, neurophysiology or histopathology. Food Chem Toxicol. 2003 ; 41 (2). 153-187.
7. Hau K., Connell D., Richardson B. A study of the biological partitioning behavior or n-alkanes and n-alkanols in causing anesthetic effects. Regul Toxicol Pharmacol. 2001 ; 35 (2 pt 1). 273-279.
8. McKee R., Medeiros A., Daughtrey W. A proposed methodology for setting occupational exposure limits for hydrocarbon solvents. J Occupat Environ Hyg. 2005 ; 2 (10). 524-542.
9. Scheffers T., Jongeneelen F., Bragt P. Development of effect-specific limit values (ESLVs) for solvent mixtures in painting. Ann Ind Hygiene. 1985 ; 29 (2). 191-199.
10. Dick R. Short duration exposures to organic solvents. The relationship between neurobehavioral test results and other indicators. Neurotoxicol Teratol. 1988 ; 10 (1). 39-50.
11. Grandjean P. Neurobehavioural Methods in Occupational and Environmental Health. Reports from the Second International Symposium, Copenhagen, August 6-9, 1985. Copenhagen: World Health Organization ; 1985.
12. Anderson N., Lundquist G., Molhave L., et al. Human response to controlled levels of toluene in six-hour exposures. Scand J Environ Health. 1983 ; 9 (5). 405-418.
13. Baelum J., Lundqvist G., Molhave L., Anderson NT Human response to varying concentrations of toluene. Int Arch Occup Environ Health. 1990 ; 62 (1). 65-71.
14. Echeverria D., Fine L., Langolf G., Schork A., Sampaio C. Acute neurobehavioral effects of toluene. Br J Ind Med. 1989 ; 46 (7). 83-95.
15. Lammers J., Meuling W., Muijser H., Freidig A., Bessems J. Neurobehavioural evaluation and kinetics of inhalation of constant or fluctuating toluene concentrations in human volunteers. Environ Toxicol Pharmacol. 2005 ; 20 (3). 431-442. (Pubitemid 41318056)
16. Lammers J., Van Asperen J., De Groot D., Pels Rijcken W. Behavioral effects and kinetics in brain in response to constant or fluctuating inhalatory exposure to toluene in the rat. Environ Toxicol Pharmacol. 2005 ; 19 (3). 625-634.
17. Savolainen K., Riihimaki V., Laine A., Kekoni J. Short-term exposure of human subjects to m-xylene and 1,1,1-trichloroethane. Int Arch Environ Health. 1981 ; 49 (1). 89-98.
18. Tegeris J., Balster R. A comparison of the acute behavioral effects of alkyl benzenes using a functional observation battery. Fund Appl Toxicol. 1994 ; 22 (2). 240-250.
19. Moser V., Becking G., MacPhail R., Kulig B. The IPCS collaborative study on neurobehavioral screening methods. Fund Appl Toxicol. 1997 ; 35 (2). 143-151.
20. Moser V., MacPhail R. International validation of a neurobehavioral screening battery: the IPCS/WHO collaborative study. Toxicol Lett. 1992 ; 64/65: 217-223.
21. Moser V., Tilson H., MacPhail R., et al. The IPCS collaborative study on Neurobehavioral Screening Methods II. Protocol design and testing procedures. Neurotoxicology. 1997 ; 18 (4). 929-938. (Pubitemid 28087272)
22. Zahlsen K., Nilsen A., Eide I., Nilsen O. Accumulation and distribution of aliphatic (n-nonane), aromatic (1,2,4-trimethylbenzene) and naphthenic (1,2,4-trimethylcyclohexane) hydrocarbons in the rat after repeated inhalation. Pharmacol Toxicol. 1990 ; 67 (5). 436-440.
23. Zahlsen K., Eide I., Nilsen O. Inhalation kinetics of C6 to C10 aliphatic, aromatic, and naphthenic hydrocarbons in rat after repeated exposures. Pharmacol Toxicol. 1992 ; 71 (2). 144-149.
24. Korsak Z., Rydzynski K. Neurotoxic effects of acute and subchronic inhalation exposure to trimethylbenzene isomers (pseudocumene, mesitylene, hemimellitene) in rats. Int J Occupat Med Environ Health. 1996 ; 9 (4). 341-349.
25. Clark D., Butterworth S., Martin J., Roderick H., Bird M. Inhalation toxicity of high flash aromatic naphtha. Toxicol Ind Health. 1989 ; 5 (3). 415-428.
26. Cushman J., Norris J., Dodd D., Darmer K., Morris C. Chronic inhalation toxicity and neurotoxicity assessment of cumene in Fischer 344 rats. J Am Coll Toxicol. 1995 ; 14 (2). 129-147.
27. Gralewicz S., Wiaderna D. Behavioral effects following subacute inhalation exposure to m-xylene or trimethylbenzene in the rat. A comparative study. Neurotoxicology. 2001 ; 22 (1). 79-89.
28. Gralewicz S., Wiaderna D., Tomas T., Rydzynski K. Behavioral changes following 4-week inhalation exposure to pseudocumene (1,2,4-trimethylbenzene) in the rat. Neurotoxicol Teratol. 1997 ; 19 (4). 327-333.
29. Wiaderna D., Gralewicz S., Tomas T. Assessment of long term-term neurotoxic effects of exposure to mesitylene (1,3,5-trimethylbenzene) based on the analysis of selected behavioral responses. Int J Occup Med Environ Health. 2002 ; 15 (4). 385-391.
30. Douglas J., McKee R., Cagen S., et al. Neurotoxicity assessment of high flash aromatic naphtha. Toxicol Ind Health. 1993 ; 9 (6). 1047-1058.
31. Carpenter C., Geary D., Myers R., et al. Petroleum hydrocarbon toxicity studies. XIV. Animal and human responses to vapors of 'high aromatic solvent. '' Toxicol Appl Pharmacol. 1977 ; 41 (2). 235-249. (Pubitemid 8172964)
32. Jarnberg J., Johanson G., Lof A. Toxicokinetics of inhaled trimethylbenzenes in man. Toxicol Appl Pharmacol. 1996 ; 140 (2). 281-288.
33. Jarnberg J., Johanson G., Lof A., Stahlbom B. Inhalation toxicokinetics of 1,2,4-trimethylbenzene in volunteers: comparison between exposure to white spirit and 1,2,4-trimethylbenzene alone. Sci Total Environ. 1997 ; 199 (1-2). 65-71.
34. Jarnberg J., Johanson A., Lof A., Stahlbom B. Toxicokinetics of 1,2,4-trimethylbenzene in humans exposed to vapours of white spirit: comparison with exposure to 1,2,4-trimethylbenzene alone. Arch Toxicol. 1998 ; 72 (8). 483-491.
35. Jones K., Meldrum M., Baird E., et al. Biological monitoring for trimethylbenzene exposure: A human volunteer study and a practical example in the workplace. Ann Occupat Hyg. 2006 ; 50 (6). 593-598.
36. Korsak Z., Majcherek W., Rydzynski K. Toxic effects of acute inhalation exposure to 1-methylnaphthalene and 2-methylnaphthalene in experimental animals. Int J Occupat Med Environ Health. 1998 ; 11 (4). 335-342. (Pubitemid 29077416)
37. Carpenter C., Kinkead E., Geary D., Sullivan L., King J. Petroleum hydrocarbon toxicity studies VII. Animal and human response to vapors of '70 solvent. '' Toxicol Appl Pharmacol. 1975 ; 34 (3). 395-412.