Toxicokinetics of 1,2,4-trimethylbenzene in humans exposed to vapours of white spirit: Comparison with exposure to 1,2,4-trimethylbenzene alone

Archives of Toxicology

Volumn 72, Issue 8, 1998, Pages 483-491

  Jarnberg J ^a,b   Johanson, G ^a,b   Lof A ^a   Stahlbom B ^c  

^a NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Dimethylhippuric acid; n Decane; n Undecane; Toxicokinetics; Trimethylbenzene

Indexed keywords

1,2,4 TRIMETHYLBENZENE; BENZENE DERIVATIVE; DRUG METABOLITE; PETROLEUM DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; DRUG MIXTURE; DRUG URINE LEVEL; EXPIRED AIR; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NEUROTOXICITY; NORMAL HUMAN; PRIORITY JOURNAL; QUESTIONNAIRE; TOXICOKINETICS; URINALYSIS; VAPOR;

ADULT; AREA UNDER CURVE; BENZENE DERIVATIVES; CENTRAL NERVOUS SYSTEM DISEASES; HALF-LIFE; HEART RATE; HUMANS; HYDROCARBONS; IRRITANTS; MALE; MIDDLE AGED; RESPIRATORY MECHANICS; SOLVENTS;

EID: 0031857426     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050532     Document Type: Article

References (20)

1. Åstrand I, Kilbom Å, Övrum P (1975) Exposure to white spirit. 1. Concentration in alveolar air and blood during rest and exercise. Scand J Work Environ Health 1: 15-30
2. Bakke O, Scheline R (1970) Hydroxylation of aromatic hydrocarbons in the rat. Toxicol Appl Pharmacol 16: 691-700
3. Busini S, Bavazzano P (1992) High-performance liquid Chromatographic determination of 3,5-dimethylhippuric acid in the occupational exposure to trimethylbenzenes. J Chromatogr 577: 180-184
4. Carpenter CP, Kinkead ER, Geary Jr, DL, Sullivan LJ, King JM (1975) Petroleum hydrocarbon toxicity studies III. Animal and human response to vapors of Stoddard solvent. Toxicol Appl Pharmacol 32: 282-297
5. Cohr K-H, Stokholm J, Bruhn P (1980) Neurologic response to white spirit exposure. Dev Toxicol Environ Sci 8: 95-102
6. Fukaya Y, Saito I, Matsumotot T, Takeuchi Y, Tokudome S (1994) Determination of 3,4-dimethylhippuric acid as a biological monitoring index for trimethylbenzene exposure in transfer printing workers. Int Arch Occup Environ Health 65: 295-297
7. Huo J-Z, Aldous S, Campbell K, Davies N (1989) Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat. Xenobiotica 19: 2, 161-170
8. Hutchinson TC, Hellebust JA, Tam D, Mackay D, Mascarenhas RA, Shiu WY (1980) Hydrocarbon and halogenated hydrocarbons in the aqueous environment. Afghan BK, Mackay D (eds), Plenum Press, New York
9. Ichiba M, Hama H, Yukitake S, Kubota M, Kawasaki S, Tomokuni K (1992) Urinary excretion of 3,4-dimethylhippuric acid in workers exposed to 1,2,4-trimethylbenzene. Int Arch Occup Health 64: 325-327
10. Järnberg J, Johanson G (1995) Liquid air partition coefficients of the trimethylbenzenes. Toxicol Ind Health 11(1): 81-88
11. Järnberg J, Johanson G, Löf A (1996) Toxicokinetics of inhaled trimethylbenzenes in man. Toxicol Appl Pharmacol 140: 281-288
12. Järnberg J, Johanson G, Löf A, Ståhlbom B (1997) Urinary excretion of dimethylhippuric acids in humans after exposure to trimethylbenzenes. Int Arch Occup Environ Health 69: 491-497
13. Kostrewski P, Wiaderna-Brycht A (1995) Kinetics of elimination of mesitylene and 3,5-dimethylbenzoic acid after experimental human exposure. Toxicol Lett 77: 259-264
14. Laham S, Potvin M (1988) Identification and determination of mesitylenic acidic metabolites in rabbit urine. Toxicol Environ Chem 24: 57-69
15. Lide DR (1993-1994). Handbook of chemistry and physics. CRC Press, Boca Raton
16. Milling Pedersen L, Cohr K-H (1984) Biochemical pattern in experimental exposure of humans to white spirit. I. The effects of a 6 hours single dose. Acta Pharmacol Toxicol 55: 317-324
17. Pfäffli P, Savolainen H (1985) Urinary dimethylbenzoic acid excretion as an indicator of occupational exposure to while spirit. J Chromatogr 337: 146-150
18. Raymer JH, Pellizzari ED, Thomas KW (1991) Elimination of volatile organic compounds in breath after exposure to occupational and environmental microenvironments. J Exp Anal Environ Epidemiol 1: 4, 439-451
19. Ståhlbom B, Järnberg J, Söderkvist P, Lindmark D (1996) Determination of dimethylhippuric acid isomers in urine by HPLC. Int Arch Occup Environ Health 69: 147-150
20. Stokholm J, Cohr K-H (1979) Exposure of humans to white spirit. III: Concentrations in alveolar air and venous blood during experimental conditions (In Danish with English summary). Arbejdstilsynet Arbejdsmiljøinstituttet, Report no 3 79