Coagulation and inflammation biomarkers may help predict the severity of community-acquired pneumonia

Respirology

Volumn 15, Issue 5, 2010, Pages 796-803

  Agapakis, Dimitrios I ^a   Tsantilas, Dionissios ^b   Psarris, Panagiotis ^b   Massa, Eleni V ^a   Kotsaftis, Panagiotis ^a   Tziomalos, Konstantinos ^a   Hatzitolios, Apostolos I ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b Georgios Gennimatas General Hospital   (Greece)

Author keywords

antithrombin III; C reactive protein; community acquired pneumonia; D dimer; protein C

Indexed keywords

ANTITHROMBIN III; C REACTIVE PROTEIN; D DIMER; PROTEIN C;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; BREATHING RATE; COMMUNITY ACQUIRED PNEUMONIA; COMPARATIVE STUDY; CONFUSION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HOSPITALIZATION; HUMAN; HYPOTENSION; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; UREMIA;

AGED; ANTITHROMBIN III; BIOLOGICAL MARKERS; BLOOD COAGULATION; C-REACTIVE PROTEIN; COMMUNITY-ACQUIRED INFECTIONS; CONFUSION; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; HYPOTENSION; MALE; MIDDLE AGED; PNEUMONIA, BACTERIAL; PROSPECTIVE STUDIES; PROTEIN C; RESPIRATORY RATE; SEVERITY OF ILLNESS INDEX; UREMIA;

EID: 77953864015     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2010.01773.x     Document Type: Article

References (31)

1. Mortensen EM, Coley CM, Singer DE et al. Causes of death for patients with community-acquired pneumonia: results from the Pneumonia Patient Outcomes Research Team cohort study. Arch. Intern. Med. 2002 162: 1059 64.
2. Woodhead M, Blasi F, Ewig S et al. Guidelines for the management of adult lower respiratory tract infections. Eur. Respir. J. 2005 26: 1138 80.
3. Stolz D, Christ-Crain M, Gencay MM et al. Diagnostic value of signs, symptoms and laboratory values in lower respiratory tract infection. Swiss Med. Wkly. 2006 136: 434 40.
4. British Thoracic Society Pneumonia Guidelines Committee. BTS guidelines for the management of community-acquired pneumonia in adults. 2004 update. [Accessed 30 Apr 2004.] Available from URL: http://www.brit-thoracic.org.uk
5. Barlow G, Nathwani D, Davey P. The CURB65 pneumonia severity score outperforms generic sepsis and early warning scores in predicting mortality in community-acquired pneumonia. Thorax 2007 62: 253 9.
6. Jimenez-Castro D, Perez-Rodriguez E, Montaner L et al. Diagnostic value of D-dimer in pulmonary embolism and pneumonia. Respiration 2001 68: 371 5.
7. Clyne B, Olshaker JS. The C-reactive protein. J. Emerg. Med. 1999 17: 1019 25.
8. Wells PS, Ginsberg JS, Anderson DR et al. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann. Intern. Med. 1998 129: 997 1005.
9. Ruiz M, Ewig S, Torres A et al. Severe community-acquired pneumonia. Risk factors and follow-up epidemiology. Am. J. Respir. Crit. Care Med. 1999 160: 923 9.
10. American Thoracic Society. Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am. J. Respir. Crit. Care Med. 2001 163: 1730 54.
11. Proietta M, Pulignano I, Porto F et al. Antithrombin III metabolism in the pulmonary vessel endothelium. Blood Coagul. Fibrinolysis 2007 18: 237 40.
12. Idell S. Coagulation, fibrinolysis and fibrin deposition in acute lung injury. Crit. Care Med. 2003 31: S213 20.
13. Levi M, Schultz MJ, Rijneveld AW et al. Bronchoalveolar coagulation and fibrinolysis in endotoxemia and pneumonia. Crit. Care Med. 2003 31: S238 42.
14. Choi G, Scultz MJ, van Till JWO et al. Disturbed alveolar fibrin turnover during pneumonia is restricted to the site of infection. Eur. Respir. J. 2004 24: 786 9.
15. Powars D, Larsen R, Johnson J et al. Epidemic meningococcemia and purpura fulminans with induced protein C deficiency. J. Infect. Dis. 1993 17: 254 61.
16. Gutovitz S, Papa L, Jimenez E et al. Protein C as an early biomarker to distinguish pneumonia from sepsis. Ann. Emerg. Med. 2008 52: S53.
17. Shorr AF, Hnatiuk OW. Circulating D-dimer in patients with sarcoidosis. Chest 2000 117: 1012 16.
18. Shorr AF, Thomas SJ, Alkins SA et al. D-dimer correlates with proinflammatory cytokine levels and outcomes in critically ill patients. Chest 2002 121: 1262 8.
19. Pettila V, Hynninen M, Takkunen O et al. Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis. Intensive Care Med. 2002 28: 1220 5.
20. Abraham E. Coagulation abnormalities in acute lung injury and sepsis. Am. J. Respir. Cell Mol. Biol. 2000 22: 401 4.
21. Günther A, Mosavi P, Heinemann S et al. Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Am. J. Respir. Crit. Care Med. 2000 161: 454 62.
22. Bone RC, Grodzin CJ, Balk RA. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 1997 112: 235 43.
23. Querol-Ribelles JM, Tenias JM, Grau E et al. Plasma D-dimer levels correlate with outcomes in patients with community-acquired pneumonia. Chest 2004 126: 1087 92.
24. Michelin E, Snijders D, Conte S et al. Procoagulant activity in children with community acquired pneumonia, pleural effusion and empyema. Pediatr. Pulmonol. 2008 43: 472 5.
25. Castell JV, Gomez-Lechon MJ, David M et al. Acute phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology 1990 12: 1179 86.
26. Almirall J, Bolibar I, Toran P et al. Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia. Chest 2004 125: 1335 42.
27. Hedlund J. Community-acquired pneumonia requiring hospitalisation: factors of importance for the short-and long term prognosis. Scand. J. Infect. Dis. Suppl. 1995 97: 1 60.
28. Seppa Y, Bloigu A, Honkanen PO et al. Severity assessment of lower respiratory tract infection in elderly patients in primary care. Arch. Intern. Med. 2001 161: 2709 13.
29. Chalmers JD, Singanayagam A, Hill AT. C-reactive protein is an independent predictor of severity in community-acquired pneumonia. Am. J. Med. 2008 121: 219 25.
30. illi A, Özdemir T, Özbudak Ö et al. Risk factors for the development of community-acquired pneumonia in young adults. Turk. Respir. J. 2001 2: 3 7.
31. Almirall J, Gonzalez CA, Balanzo X et al. Proportion of community-acquired pneumonia cases attributable to tobacco smoking. Chest 1999 116: 375 9.