Bolus delivery of mesenchymal stem cells to injured vasculature in the rabbit carotid artery produces a dysfunctional endothelium

Tissue Engineering - Part A

Volumn 16, Issue 5, 2010, Pages 1657-1665

  O'Shea, Ciara A ^a   Hynes, Sean O ^a   Shaw, Georgina ^a   Coen, Barbara A ^a   Hynes, Ailish C ^a   McMahon, Jill ^a   Murphy, Mary ^a   Barry, Frank ^a   O'Brien, Timothy ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; FLOWCHARTING; STEM CELLS;

CAROTID ARTERY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIALIZATION; ENGRAFTMENT; IN-VIVO; MESENCHYMAL STEM CELL; NEOINTIMAL FORMATION; NEOINTIMAL HYPERPLASIA; NEW ZEALAND WHITE RABBIT; PARACRINE; PLURIPOTENT; REPORTER GENE; VASCULATURE; VESSEL WALLS;

CELL CULTURE;

ORYCTOLAGUS CUNICULUS;

BETA GALACTOSIDASE;

ADENOVIRUS; ADRENERGIC SYSTEM; ANGIOGENESIS; ANIMAL; ARTICLE; CAROTID ARTERY; GENETIC TRANSDUCTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; INTIMA; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RABBIT; VASCULAR ENDOTHELIUM;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; CAROTID ARTERIES; ENDOTHELIUM, VASCULAR; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; NEOVASCULARIZATION, PHYSIOLOGIC; RABBITS; TRANSDUCTION, GENETIC; TUNICA INTIMA; VASOMOTOR SYSTEM;

EID: 77953854715     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2009.0468     Document Type: Article

References (24)

1. Lüscher, T.F., and Tanner, F.C. Endothelial regulation of vascular tone and growth. Am J Hypertens 6(7 Pt 2), 283S, 1993.
2. Shah, A.M. Paracrine modulation of heart cell functions by endothelial cells. Cardiovasc Res 31, 847, 1996.
3. He, T., Smith, L.A., Harrington, S., Nath, K.A., Caplice, N.M., and Katusic, Z.S. Transplantation of circulating en-dothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries. Stroke 35, 2378, 2004.
4. Pittenger, M.F., MacKay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., and Marshak, D.R. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143, 1999.
5. Sorrel, J.M., Baber, M.A., and Caplan, A.I. Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue Eng Part A 15, 10, 2009.
6. Chen, L., Tredget, E.E., Wu, P.Y., and Wu, Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS ONE 3, e1886, 2008.
7. Silva, G.V., Litovsky, V., Assad, J.A., Sousa, A.L., Martin, B.J., Vela, D., Coulter, S.C., Lin, J., Ober, J., Vaughn, W.K., Branco, R.V., Oliveira, E.M., He, R., Geng, Y.L., Willerson, J.T., and Perin, E.C. Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 111, 150, 2005.
8. Oswald, J., Boxberger, S., Jørgensen, B., Feldmann, S., Eh-ninger, G., Bornhäuser, M., and Werner, C. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 22, 377, 2004.
9. Wang, T., Xu, Z., Jiang, W., and Ma, A. Cell-to-cell contact induces mesenchymal stem cell to differentiate into cardio-myocyte and smooth muscle cell. Int J Cardiol 109, 74, 2006.
10. Abdi, R., Fiorina, P., Adra, C.N., Atkinson, M., and Sayegh, M.H. Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes. Diabetes 57, 1759, 2008.
11. Shimokaya, H., Aarhus, L.L., and Vanhoutte, P.M. Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. Circ Res 61, 256, 1987.
12. Carlson, C.A., Shayakhmetov, D.M., and Lieber, A. Restoration of a functional open reading frame by homologous recombination between two adenoviral vectors. Mol Ther 6, 99, 2002.
13. Gulati, R., Jevremovic, D., Peterson, T.E., Witt, T.A., Kleppe, L.S., Mueske, C.S., Lerman, A., Vile, R.G., and Simari, R.D. Autologous culture-modified mononuclear cells confer vascular protection after arterial injury. Circulation 108, 1520, 2003.
14. Kong, D., Melo, L.G., Mangi, A.A., Zhang, L., Lopez-Ilasaca, M., Perrella, M.A., Liew, C.C., Pratt, R.E., and Dzau, V.J. Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. Circulation 109, 1769, 2004.
15. Abedin, M., Tintut, Y., and Demer, L.L. Mesenchymal stem cells and the artery wall. Circ Res 95, 671, 2004.
16. Zisa, D., Shabbir, A., Suzuki, G., and Lee, T. Vascular endo-thelial growth factor (VEGF) as a key therapeutic trophic factor in bone marrow mesenchymal stem cell-mediated cardiac repair. Biochem Biophys Res Commun 390, 834, 2009.
17. Liu, J.W., Dunoyer-Geindre, S., Serre-Beinier, V., Mai, G., Lambert, J.F., Fish, R.J., Pernod, G., Buehler, L., Bounameaux, H., and Kruithof, E.K. Characterization of endothelial-like cells derived from human mesenchymal stem cells. J Thromb Haemost 5, 826, 2007.
18. Wu, X., Huang, L., Zhou, Q., Song, Y., Li, A., Jin, J., and Cui, B. Mesenchymal stem cells participating in ex vivo endo-thelium repair and its effect on vascular smooth muscle cells growth. Int J Cardiol 105, 274, 2005.
19. Kang, H.J., Kim, H.S., Zhang, S.Y., Park, K.W., Cho, H.J., Koo, B.K., Kim, Y.J., Soo Lee, D., Sohn, D.W., Han, K.S., Oh, B.H., Lee, M.M., and Park, Y.B. Effects of intracoronary infusion of peripheral blood stem cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cel randomised clinical trial. Lancet 363, 751, 2004.
20. Vulliet, P.R., Greeley, M., Halloran, S.M., MacDonald, K.A., and Kittleson, M.D. Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet 363, 783, 2004.
21. Wang, C.H., Cherng, W.J., Yang, N.I., Kuo, L.T., Hsu, C.M., Yeh, H.I., Lan, Y.J., Yeh, C.H., and Stanford, W.L. Late outgrowth endothelial cells attenuate intimal hyperplasia contributed by mesenchymal stem cells after vascular injury. Arterioscler Thromb Vasc Biol 28, 54, 2008.
22. Tanaka, K., Sata, M., Hirata, Y., and Nagai, R. Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries. Circ Res 93, 783, 2003.
23. Assmus, B., Walter, D.H., Lehmann, R., Honold, J., Martin, H., Dimmler, S., Zeiher, A.M., and Schachinger, V. Intracoronary infusion of progenitor cells is not associated with aggravated restenosis development or atherosclerotic disease progression in patients with acute myocardial infarction. Eur Heart J 27, 2989, 2006.
24. Kovacic, J.C., and Graham, R.M. Stem cell therapies for myocardial diseases. Lancet 363, 1735, 2004.