Pharmacokinetics of pseudoephedrine in rats, dogs, monkeys and its pharmacokinetic-pharmacodynamic relationship in a feline model of nasal congestion

Drug Metabolism Letters

Volumn 4, Issue 2, 2010, Pages 56-61

  Palamanda, Jairam R ^a   Mei, Hong ^a   Morrison, Richard ^a   McLeod, Robbie L ^a   McCormick, Kevin ^b   Corboz, Michel ^a   Xu, Xiaoying ^a   Korfmacher, Walter ^a   Broske, Lisa ^a   Nomeir, Amin A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Chemical Research   (United States)

Author keywords

Lc MS MS; Pharmacodynamics; Pharmacokinetics; Preclinical; Pseudoephedrine

Indexed keywords

PSEUDOEPHEDRINE; DECONGESTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAT; COLON; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STRUCTURE; EXPERIMENTAL MODEL; ILEUM; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MONKEY; NONHUMAN; NOSE CONGESTION; PRIORITY JOURNAL; ANIMAL; AREA UNDER THE CURVE; BIOAVAILABILITY; COMPARATIVE STUDY; FEMALE; HALF LIFE TIME; HUMAN; MACACA FASCICULARIS; NASAL OBSTRUCTION; RAT; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT;

ANIMALIA; CANIS FAMILIARIS; FELIDAE; RATTUS;

ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CATS; DOGS; FEMALE; HALF-LIFE; HUMANS; MACACA FASCICULARIS; MALE; NASAL DECONGESTANTS; NASAL OBSTRUCTION; PSEUDOEPHEDRINE; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

EID: 77953802169     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231210791292762     Document Type: Article

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