The Evolving Challenge of Evaluating Older Renal Transplant Candidates

Advances in Chronic Kidney Disease

Volumn 17, Issue 4, 2010, Pages 358-367

  Hartmann, Erica L ^a   Wu, Christine ^a  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

Geriatric aging comorbidity; Kidney evaluation assessment; Transplantation

Indexed keywords

CHRONIC KIDNEY DISEASE; COGNITION; COMORBIDITY; GERIATRIC PATIENT; GRAFT RECIPIENT; HUMAN; KIDNEY GRAFT; PATIENT ASSESSMENT; PRIORITY JOURNAL; REVIEW;

AGE FACTORS; AGED; AGED, 80 AND OVER; COMORBIDITY; DEMOGRAPHY; GERIATRIC ASSESSMENT; HUMANS; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MIDDLE AGED; PATIENT SELECTION;

EID: 77953776667     PISSN: 15485595     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ackd.2010.03.012     Document Type: Review

References (67)

1. Jager K.J., van Dijk P.C., Dekker F.W., et al., ERA-EDTA Registry Committee. The epidemic of aging in renal replacement therapy: An update on elderly patients and their outcomes. Clin Nephrol 60 (2003) 352-360
2. Danovitch G.M., Cohen D.J., Weir M.R., et al. Current status of kidney and pancreas transplantation in the United States, 1994-2003. Am J Transplant 5 4 Pt 2 (2005) 904-915
3. Port F.K., Merion R.M., Goodrich N.P., et al. Recent trends and results for organ donation and transplantation in the United States, 2005. Am J Transplant 6 5 Pt 2 (2006) 1095-1100
4. Wolfe R.A., Merion R.M., Roys E.C., et al. Trends in organ donation and transplantation in the United States, 1998-2007. Am J Transplant 9 4 Pt 2 (2009) 869-878
5. Rebollo P., Ortega F., Baltar J.M., et al. Health-related quality of life (HRQOL) in end stage renal disease (ESRD) patients over 65 years. Geriatr Nephrol Urol 8 (1998) 85-94
6. Oniscu G.C., Brown H., and Forsythe J.L. How great is the survival advantage of transplantation over dialysis in elderly patients?. Nephrol Dial Transplant 19 (2004) 945-951
7. Rao P.S., Merion R.M., Ashby V.B., et al. Renal transplantation in elderly patients older than 70 years of age: Results from the scientific registry of transplant recipients. Transplantation 83 (2007) 1069-1074
8. Wolfe R.A., Ashby V.B., Milford E.L., et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 341 (1999) 1725-1730
9. Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 1998-2007. Rockville, MD, Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation; Richmond, VA, United Network for Organ Sharing; Ann Arbor, MI, University Renal Research and Education Association, 2008
10. Delmonico F.L., and McBride M.A. Analysis of the wait list and deaths among candidates waiting for a kidney transplant. Transplantation 86 (2008) 1678-1683
11. Kauffman H.M., McBride M.A., Cors C.S., et al. Early mortality rates in older kidney recipients with comorbid risk factors. Transplantation 83 (2007) 404-410
12. Schold J.D., Srinivas T.R., Kayler L.K., et al. The overlapping risk profile between dialysis patients listed and not listed for renal transplantation. Am J Transplant 8 (2008) 58-68
13. Centers for Medicare and Medicaid Services: Final Rule: Hospital Conditions of Participation: Requirements for Approval and Re-approval of Transplant Centers to Perform Organ Transplants. Woodlawn, MD, Centers for Medicare and Medicaid Services. Available at: http://www.cms.hhs.gov/CertificationandComplianc/Downloads/Transplantfin al.pdf
14. Kasiske B.L., Cangro C.B., Hariharan S., et al. The evaluation of renal transplantation candidates: Clinical practice guidelines. Am J Transplant 1 Suppl 2 (2001) 3-95
15. Schold J.D., and Meier-Kriesche H.U. Which renal transplant candidates should accept marginal kidneys in exchange for a shorter waiting time on dialysis?. Clin J Am Soc Nephrol 1 (2006) 532-538
16. Oniscu G.C., Schalkwijk A.A.H., Johnson R.J., et al. Equity of access to renal transplant waiting list and renal transplantation in Scotland: Cohort Study. BMJ 327 (2003) 1-5
17. Knoll G., Cockfield S., Blydt-Hansen T., et al. Canadian society of transplantation consensus guidelines on eligibility for kidney transplantation. CMAJ 173 (2005) 1181-1184
18. Jassal S.V., Schaubel D.E., and Fenton S.S. Predicting mortality after kidney transplantation: A clinical tool. Transplant Int 18 (2005) 1248-1257
19. Danovitch G., and Savransky E. Challenges in the counseling and management of older kidney transplant candidates. Am J Kidney Dis 47 4 Suppl 2 (2006) S86-S97
20. Levey A.S., Stevens L.A., Schmid C.H., et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 150 (2009) 604-612
21. U.S. Renal Data System, USRDS 2008 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Bethesda, MD, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2008
22. Keith D.S., Nichols G.A., Gullion C.M., et al. Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 164 (2004) 659-663
23. Foley R.N., Murray A.M., Li S., et al. Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999. J Am Soc Nephrol 16 (2005) 489-495
24. O'Hare A.M., Choi A.I., Bertenthal D., et al. Age affects outcomes in chronic kidney disease. J Am Soc Nephrol 18 (2007) 2758-2765
25. Meier-Kriesche H.U., Ojo A.O., Hanson J.A., et al. Exponentially increased risk of infectious death in older renal transplant recipients. Kidney Int 59 (2001) 1539-1543
26. Ramos E.L., Kasiske B.L., Alexander S.R., et al. The evaluation of candidates for renal transplantation. The current practice of U.S. transplant centers. Transplantation 57 (1994) 490-497
27. Fritsche L., Vanrenterghem Y., Nordal K.P., et al. Practice variations in the evaluation of adult candidates for cadaveric kidney transplantation: A survey of the European Transplant Centers. Transplantation 70 (2000) 1492-1497
28. Wu C., Shapiro R., Tan H., et al. Kidney transplantation in elderly people: The influence of recipient comorbidity and living kidney donors. J Am Geriatr Soc 56 (2008) 231-238
29. Charlson M.E., Pompei P., Ales K.L., et al. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 40 (1987) 373-383
30. Beddhu S., Bruns F.J., Saul M., et al. A simple comorbidity scale predicts clinical outcomes and costs in dialysis patients. Am J Med 108 (2000) 609-613
31. Fried L., Bernardini J., and Piraino B. Charlson comorbidity index as a predictor of outcomes in incident peritoneal dialysis patients. Am J Kidney Dis 37 (2001) 337-342
32. van Manen J.G., Korevaar J.C., Dekker F.W., et al. How to adjust for comorbidity in survival studies in ESRD patients: A comparison of different indices. Am J Kidney Dis 40 (2002) 82-89
33. Hemmelgarn B.R., Manns B.J., Quan H., et al. Adapting the Charlson Comorbidity Index for use in patients with ESRD. Am J Kidney Dis 42 (2003) 125-132
34. Jassal S.V., Schaubel D.E., and Fenton S.S. Baseline comorbidity in kidney transplant recipients: A comparison of comorbidity indices. Am J Kidney Dis 46 (2005) 136-142
35. Jassal S.V., Krahn M.D., and Naglie G. Kidney transplantation in the elderly: A decision analysis. J Am Soc Nephrol 14 (2003) 187-196
36. Heldal K., Hartmann A., and Leivestad T. Clinical outcomes in elderly kidney transplant recipients are related to acute rejection episodes rather than pretransplant comorbidity. Transplantation 87 (2009) 1045-1051
37. Inouye S.K., Studenski S., Tinetti M.E., et al. Geriatric syndromes: Clinical, research and policy implications of a core geriatric concept. J Am Geriatr Soc 55 (2007) 780-791
38. Prince Market Research. Attitudes of Seniors and Baby Boomers on Aging in Place (2007), Prince Market Research, Nashville, TN
39. Katz S., Ford A.B., Moskowitz R.W., et al. Studies of illness in the aged. The index of ADL: A standardized measure of biological and psychosocial function. JAMA 185 (1963) 914-919
40. Lawton M.P., and Brody E.M. Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist 9 (1969) 179-186
41. Nasreddine Z.S., Phillips N.A., Bédirian V., et al. The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53 (2005) 695-699
42. Johansen K.L., Chertow G.M., Ng A.V., et al. Physical activity levels in patients on hemodialysis and healthy sedentary controls. Kidney Int 57 (2000) 2564-2570
43. Johansen K.L., Chertow G.M., da S.M., et al. Determinants of physical performance in ambulatory patients on hemodialysis. Kidney Int 60 (2001) 1586-1591
44. Bohannon R.W., Hull D., and Palmeri D. Muscle strength impairments and gait performance deficits in kidney transplantation candidates. Am J Kidney Dis 24 (1994) 480-485
45. Blake C., and O'Meara Y.M. Subjective and objective physical limitations in high-functioning renal dialysis patients. Nephrol Dial Transplant 19 (2004) 3124-3129
46. Kempeneers G., Noakes T.D., van Zyl-Smit R., et al. Skeletal muscle limits the exercise tolerance of renal transplant recipients: Effects of a graded exercise training program. Am J Kidney Dis 16 (1990) 57-65
47. Painter P. The importance of exercise training in rehabilitation of patients with end-stage renal disease. Am J Kidney Dis 24 1 Suppl 1 (1994) S2-S9
48. Painter P., Carlson L., Carey S., et al. Low-functioning hemodialysis patients improve with exercise training. Am J Kidney Dis 36 (2000) 600-608
49. Sui X., Laditka J.N., Hardin J.W., et al. Estimated functional capacity predicts mortality in older adults. J Am Geriatr Soc 55 (2007) 1940-1947
50. Rolland Y., Lauwers-Cances V., Cesari M., et al. Physical performance measures as predictors of mortality in a cohort of community-dwelling older French women. Eur J Epidemiol 21 (2006) 113-122
51. Ostir G.V., Kuo Y.F., Berges I.M., et al. Measures of lower body function and risk of mortality over 7 years of follow-up. Am J Epidemiol 166 (2007) 599-605
52. Newman A.B., Simonsick E.M., Naydeck B.L., et al. Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability. JAMA 295 (2006) 2018-2026
53. Stack A.G., Molony D.A., Rives T., et al. Association of physical activity with mortality in the US dialysis population. Am J Kidney Dis 45 (2005) 690-701
54. Kutner N.G., Zhang R., Bowles T., et al. Pretransplant physical functioning and kidney patients' risk for posttransplantation hospitalization/death: Evidence from a national cohort. Clin J Am Soc Nephrol 1 (2006) 837-843
55. Studenski S., Perera S., Wallace D., et al. Physical performance measures in the clinical setting. J Am Geriatr Soc 51 (2003) 314-322
56. Cesari M., Kritchevsky S.B., Penninx B.W., et al. Prognostic value of usual gait speed in well-functioning older people-Results from the health, aging and body composition study. J Am Geriatr Soc 53 (2005) 1675-1680
57. Cesari M., Penninx B.W., Newman A.B., et al. Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study). Am J Cardiol 92 (2003) 522-528
58. Hartmann E.L., Kitzman D., Rocco M., et al. Physical function in older candidates for renal transplantation: An impaired population. Clin J Am Soc Nephrol 4 (2009) 588-594
59. Fazekas G., Fazekas F., Schmidt R., et al. Brain MRI findings and cognitive impairment in patients undergoing chronic hemodialysis treatment. J Neurol Sci 134 (1995) 83-88
60. Sehgal A.R., Grey S.F., DeOreo P.B., et al. Prevalence, recognition, and implications of mental impairment among hemodialysis patients. Am J Kidney Dis 30 (1997) 41-49
61. Thornton W.L., Shapiro R., Deria S., et al. Differential impact of age on verbal memory and executive functioning in chronic kidney disease. J Int Neuropsychol Soc 13 (2007) 344-353
62. Kurella M., Chertow G.M., Fried L.F., et al. Chronic kidney disease and cognitive impairment in the elderly: The health, aging, and body composition study. J Am Soc Nephrol 16 (2005) 2127-2133
63. Pereira A.A., Weiner D.E., Scott T., et al. Subcortical cognitive impairment in dialysis patients. Hemodial Int 11 (2007) 309-314
64. Murray A.M., Tupper D.E., Knopman D.S., et al. Cognitive impairment in hemodialysis patients is common. Neurology 67 (2006) 216-223
65. Seliger S.L., and Sarnak M.J. Subclinical vascular disease of the brain in dialysis patients. Am J Kidney Dis 50 (2007) 8-10
66. Rakowski D.A., Caillard S., Agodoa L.Y., et al. Dementia as a predictor of mortality in dialysis patients. Clin J Am Soc Nephrol 1 (2006) 1000-1005
67. Murray A.M. Cognitive impairment in the agingdialysis and chronic kidney disease populations: An occult burden. Adv Chronic Kidney Dis 15 (2008) 123-132