A semi-mechanistic model of CP-690,550-induced reduction in neutrophil counts in patients with rheumatoid arthritis

Journal of Clinical Pharmacology

Volumn 50, Issue 6, 2010, Pages 679-687

  Gupta, Pankaj ^a   Friberg, Lena E ^b   Karlsson, Mats O ^b   Krishnaswami, Sriram ^a   French, Jonathan ^a  

^a PFIZER INC   (United States)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Absolute neutrophil count (ANC); JAK3; Mean transit time (MTT); Rheumatoid arthritis; Semi mechanistic model

Indexed keywords

4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; PLACEBO;

ADULT; AGED; ARTICLE; CELL COMPARTMENTALIZATION; CELL MATURATION; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DOSE RESPONSE; DRUG ACTIVITY; FEMALE; FOLLOW UP; HUMAN; INFLAMMATION; MALE; NEUTROPHIL COUNT; PHASE 2 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; STEM CELL; TREATMENT DURATION;

ADOLESCENT; ADULT; AGED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; NEUTROPENIA; PYRIMIDINES; PYRROLES; TIME FACTORS;

EID: 77953775745     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270009346060     Document Type: Article

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