Turning cardiac excitation into cell contraction: The importance of sex differences

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 1, 2010, Pages

  Marsh, James D ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; SEX HORMONE;

ANDROPAUSE; CALCIUM TRANSPORT; EDITORIAL; EXCITATION; HEART CONTRACTION; HEART MUSCLE CELL; HUMAN; IN VIVO STUDY; MARATHON RUNNER; MENOPAUSE; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SEX DIFFERENCE;

ACTION POTENTIALS; ANIMALS; CALCIUM SIGNALING; EXCITATION CONTRACTION COUPLING; HEART VENTRICLES; HUMANS; KINETICS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; RATS; SARCOPLASMIC RETICULUM; SEX FACTORS;

EID: 77953767105     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00444.2010     Document Type: Editorial

References (18)

1. Adams K, Vincent LM, McAllister SM, el-Ashmawy H, Sheps DS. The influence of age and gender on left ventricular response to supine exercise in asymptomatic normal subjects. Am Heart J 113: 732-742, 1987.
2. Cheng S, Fernandes VR, Bluemke DA, McClelland RL, Kronmal RA, Lima JA. Age-related ventricular remodeling and associated risk for cardiovascular outcomes: the Multi-Ethnic Study of Atherosclerosis. Circ Cardiovasc Imaging 2: 191-198, 2009.
3. 2+ handling and contractile function. Physiol Res 58: 293-297, 2009.
4. Farrell SR, Ross JL, Howlett SE. Sex differences in mechanisms of cardiac excitation-contraction coupling in rat ventricular myocytes. Am J Physiol Heart Circ Physiol (May 7, 2010). doi:10.1152/ajpheart.00299.2010.
5. Golden KL, Marsh JD, Jiang Y, Brown T, Moulden J. Gonadectomy of adult male rats reduces contractility of isolated cardiac myocytes. Am J Physiol Endocrinol Metab 285: E449-E453, 2003. (Pubitemid 37010820)
6. Golden KL, Marsh JD, Jiang Y. Testosterone regulates mRNA levels of calcium regulatory proteins in cardiac myocytes. Horm Metab Res 36: 197-202, 2004.
7. 2+/calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ Res 99: 398-406, 2006.
8. Hanley PC, Zinsmeister AR, Clements IP, Bove AA, Brown ML, Gibbons RJ. Gender-related differences in cardiac response to supine exercise assessed by radionuclide angiography. J Am Coll Cardiol 13: 625-629, 1989.
9. Howlett SE. Age-associated changes in excitation-contraction coupling are more prominent in ventricular myocytes from male rats than in myocytes from female rats. Am J Physiol Heart Circ Physiol 298: H659-H670, 2010.
10. Liu L, Fan QI, El-Zaru MR, Vanderpool K, Hines RN, Marsh JD. Regulation of DHP receptor expression by elements in the 5′-flanking sequence. Am J Physiol Heart Circ Physiol 278: H1153-H1162, 2000.
11. 2+/calmodulin-dependent protein kinase II. Br J Pharmacol 157: 705-715, 2009.
12. Petre RE, Quaile MP, Rossman EI, Ratcliffe SJ, Bailey BA, Houser SR, Margulies KB. Sex-based differences in myocardial contractile reserve. Am J Physiol Regul Integr Comp Physiol 292: R810-R818, 2007.
13. Scheuer J, Malhotra A, Schaible TF, Capasso J. Effects of gonadectomy and hormonal replacement on rat hearts. Circ Res 61: 12-19, 1987. (Pubitemid 17123077)
14. Shakespeare W. Sonnet 20. In: The Works of William Shakespeare, Boston: Phillips Sampson, 1852.
15. Shakespeare W. Two gentlemen of verona. In: The Works of William Shakespeare, Boston: Phillips Sampson, 1852.
16. Vizgirda VM, Wahler GM, Sondgeroth KL, Ziolo MT, Schwertz DW. Mechanisms of sex differences in rat cardiac myocyte response to beta-adrenergic stimulation. Am J Physiol Heart Circ Physiol 282: H256-H263, 2002.
17. Wattanapermpool J, Reiser PJ. Differential effects of ovariectomy on calcium activation of cardiac and soleus myofilaments. Am J Physiol Heart Circ Physiol 277: H467-H473, 1999. (Pubitemid 29415958)
18. Yarnoz MJ, Curtis AB. More reasons why men and women are not the same (gender differences in electrophysiology and arrhythmias). Am J Cardiol 101: 1291-1296, 2008.