Impact of hyperlipidemia on plasma protein binding and hepatic drug transporter and metabolic enzyme regulation in a rat model of gestational diabetes

Journal of Pharmacology and Experimental Therapeutics

Volumn 334, Issue 1, 2010, Pages 21-32

  Anger, Gregory J ^a   Piquette Miller, Micheline ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CYTOCHROME P450; CYTOCHROME P450 2A1; CYTOCHROME P450 2B9; CYTOCHROME P450 2D3; GLIBENCLAMIDE; INSULIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; SAQUINAVIR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG MECHANISM; ENZYME REGULATION; FEMALE; HYPERLIPIDEMIA; LIPID METABOLISM; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEOMICS; RAT; STREPTOZOCIN DIABETES; ULTRAFILTRATION; UPREGULATION;

ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DIABETES MELLITUS, EXPERIMENTAL; DIABETES, GESTATIONAL; DOWN-REGULATION; FEMALE; GESTATIONAL AGE; GLYBURIDE; HYPERLIPIDEMIAS; INSULIN; LIPID METABOLISM; LIPIDS; LIVER; PREGNANCY; PROTEIN BINDING; PROTEOMICS; RATS; RATS, SPRAGUE-DAWLEY; SAQUINAVIR; STREPTOZOCIN; TANDEM MASS SPECTROMETRY; UP-REGULATION;

EID: 77953754772     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.165639     Document Type: Article

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