Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression

European Heart Journal

Volumn 31, Issue 12, 2010, Pages 1529-1537

  Couvreur, Nicolas ^a,b,c   Tissier, Renaud ^a,b,c   Pons, Sandrine ^a,b   Chetboul, Valérie ^a,c   Gouni, Vassiliky ^c   Bruneval, Patrick ^e   Mandet, Chantal ^e   Pouchelon, Jean Louis ^a,c   Berdeaux, Alain ^a,b,c,d   Ghaleh, Bijan ^a,b,c,d  

^a INSERM   (France)

^b FACULTÉ DE MÉDECINE   (France)

^c ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^d Groupe Hospitalier Albert Chenevier   (France)

^e PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

Author keywords

Calcium handling; Chronic heart rate reduction; If channel; Infarction; Ivabradine; Left ventricular dysfunction

Indexed keywords

CALCIUM; CALSEQUESTRIN; FKBP12 PROTEIN; IVABRADINE; PHOSPHOLAMBAN; PROTEIN; RYANODINE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; SODIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEART EJECTION FRACTION; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART RATE; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION; SINGLE DRUG DOSE; SYSTOLE; TREATMENT DURATION;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BENZAZEPINES; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; CORONARY OCCLUSION; HEART RATE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION; RABBITS; STROKE VOLUME; TACROLIMUS BINDING PROTEIN 1A; VENTRICULAR DYSFUNCTION, LEFT;

EID: 77953745901     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehp554     Document Type: Article

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