Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin

Biophysical Chemistry

Volumn 150, Issue 1-3, 2010, Pages 73-79

  Sellin, Daniel ^a   Yan, Li Mei ^b   Kapurniotu, Aphrodite ^b   Winter, Roland ^a  

^a TU DORTMUND UNIVERSITY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Amyloid; ATR FTIR spectroscopy; Lipid bilayer; Peptide inhibitors; Protein aggregation

Indexed keywords

AMYLIN; HEXAPEPTIDE; INSULIN; ISLET AMYLOID POYLPEPTIDE GI; NFGAIL GI; POLYPEPTIDE; RAT ISLET AMYLOID POYLPEPTIDE; UNCLASSIFIED DRUG; (N-ME)G24, (N-ME)I26-IAPP; 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOGLYCEROL; 1,2-OLEOYLPHOSPHATIDYLCHOLINE; AMYLOID; LIPID BILAYER; PEPTIDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL;

AMINO TERMINAL SEQUENCE; ARTICLE; ATTENUATED TOTAL REFLECTION FOURIER TRANSFORM INFRARED SPECTROSCOPY; BETA SHEET; CELL MEMBRANE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG MECHANISM; EXTRACELLULAR MATRIX; INFRARED SPECTROSCOPY; LIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LIPID INTERACTION; SECRETORY GRANULE; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HUMAN; LIPID BILAYER; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; RAT;

AMINO ACID SEQUENCE; AMYLOID; ANIMALS; HUMANS; INSULIN; LIPID BILAYERS; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLGLYCEROLS; PROTEIN CONFORMATION; RATS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

RATTUS;

EID: 77953710075     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpc.2010.01.006     Document Type: Article

References (30)

1. Hull R.L., Westermark G.T., Westermark P., Kahn S.E. Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes. J. Clin. Endocrinol. Metab. 2004, 89:3629-3643.
2. Kahn S.E., D'Alessio D.A., Schwartz M.W., Fuijimoto W.Y., Ensinck J.W., Taborsky G.J., Porte D. Evidence of cosecretion of islet amyloid polypeptide and insulin by β-cells. Diabetes 1990, 39:634-638.
3. Knight J.D., Williamson J.A., Miranker A.D. Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin. Protein Sci. 2008, 17:1-7.
4. Rushing P.A., Hagen M.M., Seeley R.J., Lutz T.A., D'Alessio D.A., Air E.L., Woods S.C. Inhibition of central amylin signaling increase food intake and body adiposity in rats. Endocrinology 2001, 142:5035-5038.
5. Grudzielanek S., Smirnovas V., Winter R. The effects of various membrane physical-chemical properties on the aggregation kinetics of insulin. Chem. Phys. Lipids 2007, 149:28-39.
6. Knight J.D., Miranker A.D. Phospholipid catalysis of diabetic amyloid assembly. J. Mol. Biol. 2004, 341:1175-1187.
7. Jayasinghe S.A., Langen R. Lipid membranes modulate the structure of islet amyloid polypeptide. Biochemistry 2005, 44:12113-12119.
8. Knight J.D., Hebda J.A., Miranker A.D. Conserved and cooperative assembly of membrane-bound α-helical states of islet amyloid polypeptide. Biochemistry 2006, 45:9496-9508.
9. Engel M.F.M., Yigittop H., Elgersma R.C., Rijkers D.T.S., Liskamp R.M.J., de Kruiff B., Höppener J.W.M., Killian J.A. Islet amyloid polypeptide inserts into phospholipid monolayers as monomer. J. Mol. Biol. 2006, 356:783-789.
10. Lopes D.H.J., Meister A., Gohlke A., Hauser A., Blume A., Winter R. Mechanism of islet amyloid polypeptide fibrillation at lipid interfaces studied by infrared reflection absorption spectroscopy. Biophys. J. 2007, 93:3132-3141.
11. Domanov Y.A., Kinnunen P.K.J. Islet amyloid polypeptide forms rigid lipid-protein amyloid fibrils on supported phospholipid bilayers. J. Mol. Biol. 2008, 376:42-54.
12. Maarten F.M., Engel L.K., Kleijer C.C., Meeldijk H.J.D., Jacobs J., Verkleij A.J., de Kruijff B., Killian J.A., Höppener J.W.M. Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane. Proc. Natl Acad. Sci. USA 2008, 105:6033-6038.
13. Kayed R., Bernhagen J., Greenfield N., Sweimeh K., Brummer H., Voelter W., Kapurniotu A. Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid formation in vitro. J. Mol. Biol. 1999, 287:781-796.
14. Gilead S., Wolfenson H., Gazit E. Molecular mapping of the recognition interface between the islet amyloid polypeptide and insulin. Angew. Chem. Int. Ed. 2006, 45:6476-6480.
15. Singh G., Brovchenko I., Oleinikova A., Winter R. Peptide aggregation in finite systems. Biophys. J. 2008, 95:3208-3221.
16. Yan L.-M., Velkova A., Tatarek-Nossol M., Andreetto E., Kapurniotu A. IAPP mimic blocks Aβ cytotoxic self-assembly: cross-suppression of amyloid toxicity of Aβ and IAPP suggests a molecular link between Alzheimer's disease and type II diabetes. Angew. Chem. Int. Ed. 2007, 46:1246-1252.
17. Velkova A., Tatarek-Nossol M., Andreetto E., Kapurniotu A. Exploiting cross-amyloid interactions to inhibit protein aggregation but not function: nanomolar affinity inhibition of insulin aggregation by an IAPP mimic. Angew. Chem. Int. Ed. 2008, 47:7114-7118.
18. Mishra R., Bulic B., Sellin D., Jha S., Waldmann H., Winter R. Small-molecule inhibitors of islet amyloid polypeptide fibril formation. Angew. Chem. Int. Ed. 2008, 47:4679-4682.
19. Kapurniotu A. Amyloidogenicity and cytotoxicity of islet amyloid polypeptide. Biopolymers 2001, 60:438-459.
20. Kapurniotu A., Schmauder A., Tenidis K. Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity. J. Mol. Biol. 2002, 315:339-350.
21. Tatarek-Nossol M., Yan L.-M., Schmauder A., Tenidis K., Westermark G., Kapurniotu A. Inhibition of hIAPP amyloid-fibril formation and apoptotic cell death by a designed hIAPP amyloid-core-containing hexapeptide. Chem. Biol. 2005, 12:797-809.
22. Tenidis K., Waldner M., Bernhagen J., Fischle W., Bergmann M., Weber M., Merkle M.-L., Voelter W., Brunner H., Kapurniotu A. Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties. J. Mol. Biol. 2000, 295:1055-1071.
23. Yan M.-L., Tatarek-Nossol M., Velkova A., Kazantzis A., Kapurniotu A. Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis. Proc. Natl Acad. Sci. USA 2006, 103:2046-2051.
24. Grudzielanek S., Smirnovas V., Winter R. Solvation-assisted pressure tuning of insulin fibrillation: from novel aggregation pathways to biotechnological applications. J. Mol. Biol. 2006, 356:497-509.
25. Cordeiro Y., Kraineva J., Suarez M.C., Tempesta A.G., Kelly J.W., Silva J.L., Winter R., Foguel D. Fourier transform infared spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin. Biophys. J. 2006, 91:957-967.
26. Radovan D., Smirnovas V., Winter R. Effect of pressure on islet amyloid polypeptide aggregation: revealing the polymorphic nature of fibrillation process. Biochemistry 2008, 47:6352-6360.
27. Zein M., Winter R. Effect of temperature, pressure and lipid acyl-chain length on the structure and phase behaviour of phospholipid-gramicidin bilayers. Phys. Chem. Chem. Phys. 2000, 2:4545-4551.
28. Dzwolak W., Grudzielanek S., Smirnovas V., Ravindra R., Nicolini C., Jansen R., Loksztejn A., Porowski S., Winter R. Ethanol-perturbed amyloidogenic self-assembly of insulin: looking for origins of amyloid strains. Biochemistry 2005, 44:8948-8958.
29. Jha S., Sellin D., Seidel R., Winter R., Amyloidogenic R. propensities and conformational properties of ProIAPP and IAPP in the presence of lipid bilayer membranes. J. Mol. Biol. 2009, 389:907-920.
30. Evers F., Jeworrek C., Tiemeyer S., Weise K., Sellin D., Paulus M., Struth B., Tolan M., Winter R. Elucidating the mechanism of lipid membrane-induced IAPP fibrillogenesis and its inhibition by the red wine compound resveratrol. A synchrotron x-ray reflectivity study. J. Am. Chem. Soc. 2009, 131:9516-9521.