Epigenetics in polycystic ovary syndrome: a pilot study of global DNA methylation

Fertility and Sterility

Volumn 94, Issue 2, 2010, Pages

  Xu, Ning ^a   Azziz, Ricardo ^a,b   Goodarzi, Mark O ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA methylation; Epigenetics; polycystic ovary syndrome

Indexed keywords

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; FEMALE; HUMAN; HYPERANDROGENISM; INSULIN RELEASE; INSULIN RESISTANCE; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL;

EID: 77953709665     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2009.10.020     Document Type: Article

References (24)

1. Goodarzi M.O. Looking for polycystic ovary syndrome genes: rational and best strategy. Semin Reprod Med 26 (2008) 5-13
2. Shaw L.M., and Elton S. Polycystic ovary syndrome: a transgenerational evolutionary adaptation. Br J Obstet Gynecol 115 (2008) 144-148
3. Dumesic D.A., Abbott D.H., and Padmanabhan V. Polycystic ovary syndrome and its developmental origins. Rev Endocrin Metab Disord 8 (2007) 127-141
4. Abbott D.H., Barnett D.K., Bruns C.M., and Dumesic D.A. Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?. Hum Reprod Update 11 (2005) 357-374
5. Xita N., and Tsatsoulis A. Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies. J Clin Endocrinol Metab 91 (2006) 1660-1666
6. Waterland R.A. Is epigenetics an important link between early life events and adult disease?. Horm Res 71 Suppl 1 (2009) 13-16
7. Prins G.S., Birch L., Tang W.Y., and Ho S.M. Developmental estrogen exposures predispose to prostate carcinogenesis with aging. Reprod Toxicol 23 (2007) 374-382
8. Bromer J.G., Wu J., Zhou Y., and Taylor H.S. Hypermethylation of homeobox A10 by in utero diethylstilbestrol exposure: an epigenetic mechanism for altered developmental programming. Endocrinology 150 (2009) 3376-3382
9. Homburg R. Androgen circle of polycystic ovary syndrome. Hum Reprod 24 (2009) 1548-1555
10. Li Z., and Huang H. Epigenetic abnormality: a possible mechanism underlying the fetal origin of polycystic ovary syndrome. Med Hypoth 70 (2008) 638-642
11. Martin-Gronert M.S., and Ozanne S.E. Programming of appetite and type 2 diabetes. Early Hum Dev 81 (2005) 981-988
12. Ho S.M., Tang W.Y., Belmonte de Frausto J., and Prins G.S. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 66 (2006) 5624-5632
13. Hickey T.E., Legro R.S., and Norman R.J. Epigenetic modification of the X chromosome influences susceptibility to polycystic ovary syndrome. J Clin Endocrinol Metab 91 (2006) 2789-2791
14. Shah N.A., Antoine H.J., Pall M., Taylor K.D., Azziz R., and Goodarzi M.O. Association of androgen receptor CAG repeat polymorphism and polycystic ovary syndrome. J Clin Endocrinol Metab 93 (2008) 1939-1945
15. Hickey T., Chandy A., and Norman R.J. The androgen receptor CAG repeat polymorphism and X-chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome. J Clin Endocrinol Metab 87 (2002) 161-165
16. Feinberg A.P. Epigenetics at the epicenter of modern medicine. JAMA 299 (2008) 1345-1350
17. Campion J., Milagro F.I., and Martinez J.A. Individuality and epigenetics in obesity. Obes Rev 10 (2009) 383-392
18. Goodarzi M.O., Jones M.R., Chen Y.D., and Azziz R. First evidence of genetic association between AKT2 and polycystic ovary syndrome. Diabetes Care 31 (2008) 2284-2287
19. Azziz R., Woods K.S., Reyna R., Key T.J., Knochenhauer E.S., and Yildiz B.O. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 89 (2004) 2745-2749
20. Zawadzki J.K., and Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A., Givens J.R., Haseltine F., and Merriam G.R. (Eds). Polycystic Ovary Syndrome (1992), Blackwell Scientific Publications, Cambridge 377-384
21. Fraga M.F., Ballestar E., Paz M.F., Ropero S., Setien F., Ballestar M.L., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 102 (2005) 10604-10609
22. Song F., Mahmood S., Ghosh S., Liang P., Smiraglia D.J., Nagase H., et al. Tissue specific differentially methylated regions (TDMR): changes in DNA methylation during development. Genomics 93 (2009) 130-139
23. Bjornsson H.T., Sigurdsson M.I., Fallin M.D., Irizarry R.A., Aspelund T., Cui H., et al. Intra-individual change over time in DNA methylation with familial clustering. JAMA 299 (2008) 2877-2883
24. Shimabukuro M., Sasaki T., Imamura A., Tsujita T., Fuke C., Umekage T., et al. Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia. J Psychiatr Res 41 (2007) 1042-1046