Intermittent methylphenidate during adolescent development produces locomotor hyperactivity and an enhanced response to cocaine compared to continuous treatment in rats

Pharmacology Biochemistry and Behavior

Volumn 96, Issue 2, 2010, Pages 166-174

  Griggs, Richard ^a   Weir, Corey ^a   Wayman, Wesley ^a   Koeltzow, Timothy E ^a  

^a BRADLEY UNIVERSITY   (United States)

Author keywords

Adolescence; Attention deficit hyperactivity disorder; Cocaine; Extinction; Light dark chamber; Locomotion; Methylphenidate; Open field; Osmotic minipump; Reinstatement; Self administration; T maze

Indexed keywords

COCAINE; METHYLPHENIDATE;

ADOLESCENT; ADOLESCENT DEVELOPMENT; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INTERMITTENT THERAPY; DRUG MEGADOSE; DRUG SELF ADMINISTRATION; DRUG SENSITIZATION; EXPLORATORY BEHAVIOR; HYPERACTIVITY; INSTRUMENTAL CONDITIONING; LIGHT DARK CYCLE; LOCOMOTION; LOW DRUG DOSE; MALE; MAZE TEST; NONHUMAN; OPEN FIELD BEHAVIOR; OSMOTIC PUMP; PRIORITY JOURNAL; RAT; TREATMENT DURATION; TREATMENT INDICATION; AGE; ANIMAL; CHEMICALLY INDUCED; COMPARATIVE STUDY; DRUG ADMINISTRATION; DRUG EFFECTS; DRUG POTENTIATION; HYPERKINESIA; SPRAGUE DAWLEY RAT;

AGE FACTORS; ANIMALS; COCAINE; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG SYNERGISM; EXPLORATORY BEHAVIOR; HYPERKINESIS; MALE; MAZE LEARNING; METHYLPHENIDATE; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 77953707162     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.04.026     Document Type: Article

References (61)

1. Achat-Mendes C., Anderson K.L., Itzhak Y. Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood. Neuropharmacology 2003, 45:106-115.
2. Adriani W., Canese R., Podo F., Laviola G. 1H MRS-detectable metabolic brain changes and reduced impulsive behavior in adult rats exposed to methylphenidate during adolescence. Neurotoxicol Teratol 2007, 29:116-125.
3. Adriani W., Leo D., Greco D., Rea M., Di P.U., Laviola G., Perrone-Capano C. Methylphenidate administration to adolescent rats determines plastic changes on reward-related behavior and striatal gene expression. Neuropsychopharmacology 2006, 31:1946-1956.
4. Adriani W., Macri S., Pacifici R., Laviola G. Peculiar vulnerability to nicotine oral self-administration in mice during early adolescence. Neuropsychopharmacology 2002, 27:212-224.
5. Algahim M.F., Yang P.B., Wilcox V.T., Burau K.D., Swann A.C., Dafny N. Prolonged methylphenidate treatment alters the behavioral diurnal activity pattern of adult male Sprague-Dawley rats. Pharmacol Biochem Behav 2009, 92:93-99.
6. Andersen S.L., Arvanitogiannis A., Pliakas A.M., LeBlanc C., Carlezon W.A. Altered responsiveness to cocaine in rats exposed to methylphenidate during development. Nat Neurosci 2002, 5:13-14.
7. Augustyniak P.N., Kourrich S., Rezazadeh S.M., Stewart J., Arvanitogiannis A. Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder. Behav Brain Res 2006, 167:379-382.
8. Bolanos C.A., Barrot M., Berton O., Wallace-Black D., Nestler E.J. Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biol Psychiatry 2003, 54:1317-1329.
9. Botly L.C., Burton C.L., Rizos Z., Fletcher P.J. Characterization of methylphenidate self-administration and reinstatement in the rat. Psychopharmacology (Berl) 2008, 199:55-66.
10. Brandon C.L., Marinelli M., Baker L.K., White F.J. Enhanced reactivity and vulnerability to cocaine following mehtylphenidate treatment in adolescent rats. Neuropsychopharmacology 2001, 25:651-661.
11. Britton G.B., Bethancourt J.A. Characterization of anxiety-related responses in male rats following prolonged exposure to therapeutic doses of oral methylphenidate. Pharmacol Biochem Behav 2009, 93:451-459.
12. Carlezon W.A., Mague S.D., Andersen S.L. Enduring behavioral effects of early exposure to methylphenidate in rats. Biol Psychiatry 2003, 54:1330-1337.
13. Chefer V.I., Zakharova I., Shippenberg T.S. Enhanced responsiveness to novelty and cocaine is associated with decreased basal dopamine uptake and release in the nucleus accumbens: quantitative microdialysis in rats under transient conditions. J Neurosci 2003, 23:3076-3084.
14. Corkum P., Panton R., Ironside S., Macpherson M., Williams T. Acute impact of immediate release methylphenidate administered three times a day on sleep in children with attention-deficit/hyperactivity disorder. J Pediatr Psychol 2008, 33:368-379.
15. Crawford C.A., Villafranca S.W., Cyr M.C., Farley C.M., Reichel C.M., Gheorghe S.L., et al. Effects of early methylphenidate exposure on morphine- and sucrose-reinforced behaviors in adult rats: relationship to dopamine D2 receptors. Brain Res 2007, 1139:245-253.
16. Darredeau C., Barrett S.P., Jardin B., Pihl R.O. Patterns and predictors of medication compliance, diversion, and misuse in adult prescribed methylphenidate users. Hum Psychopharmacol 2007.
17. Deacon R.M., Rawlins J.N. T-maze alternation in the rodent. Nat Protoc 2006, 1:7-12.
18. Faraone S.V. Using meta-analysis to compare the efficacy of medications for attention-deficit/hyperactivity disorder in youths. P. T. 2009, 34:678-694.
19. Faraone S.V., Wilens T. Does stimulant treatment lead to substance use disorders?. J Clin Psychiatry 2003, 64(Suppl 11):9-13.
20. File S.E., Lippa A.S., Beer B., Lippa M.T. Animal tests of anxiety. Curr Protoc Neurosci 2004, Chapter 8: Unit.
21. Gray J.D., Punsoni M., Tabori N.E., Melton J.T., Fanslow V., Ward M.J., et al. Methylphenidate administration to juvenile rats alters brain areas involved in cognition, motivated behaviors, appetite, and stress. J Neurosci 2007, 27:7196-7207.
22. Greenhill L.L., Pliszka S., Dulcan M.K., Bernet W., Arnold V., Beitchman J., et al. Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 2002, 41:26S-49S.
23. Jensen P.S. Current concepts and controversies in the diagnosis and treatment of attention deficit hyperactivity disorder. Curr Psychiatry Rep 2000, 2:102-109.
24. King G.R., Kuhn C., Ellinwood E.H. Dopamine efflux during withdrawal from continuous or intermittent cocaine. Psychopharmacology (Berl) 1993, 111:179-184.
25. Koeltzow T.E., Vezina P. Locomotor activity and cocaine-seeking behavior during acquisition and reinstatement of operant self-administration behavior in rats. Behav Brain Res 2005, 160:250-259.
26. Koeltzow T.E., White F.J. Behavioral depression during cocaine withdrawal is associated with decreased spontaneous activity of ventral tegmental area dopamine neurons. Behav Neurosci 2003, 117:860-865.
27. Kollins S.H. ADHD, substance use disorders, and psychostimulant treatment: current literature and treatment guidelines. J Atten Disord 2008, 12:115-125.
28. Kuczenski R., Segal D.S. Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: relative roles of dopamine and norepinephrine. J Pharmacol Exp Ther 2001, 296:876-883.
29. LeBlanc-Duchin D., Taukulis H.K. Chronic oral methylphenidate administration to periadolescent rats yields prolonged impairment of memory for objects. Neurobiol Learn Mem 2007, 88:312-320.
30. Lynch W.J., Girgenti M.J., Breslin F.J., Newton S.S., Taylor J.R. Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes. Brain Res 2008, 1213:166-177.
31. Mague S.D., Andersen S.L., Carlezon W.A. Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats. Biol Psychiatry 2005, 57:120-125.
32. Mannuzza S., Klein R.G., Truong N.L., Moulton J.L., Roizen E.R., Howell K.H., et al. Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. Am J Psychiatry 2008, 165:604-609.
33. Marinelli M., White F.J. Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons. J Neurosci 2000, 20:8876-8885.
34. Markowitz J.S., Straughn A.B., Patrick K.S., Devane C.L., Pestreich L., Lee J., et al. Pharmacokinetics of methylphenidate after oral administration of two modified-release formulations in healthy adults. Clin Pharmacokinet 2003, 42:393-401.
35. McClung C.A., Sidiropoulou K., Vitaterna M., Takahashi J.S., White F.J., Cooper D.C., et al. Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci USA 2005, 102:9377-9381.
36. McFadyen M.P., Brown R.E., Carrey N. Subchronic methylphenidate administration has no effect on locomotion, emotional behavior, or water maze learning in prepubertal mice. Dev Psychobiol 2002, 41:123-132.
37. Moustgaard A., Hau J., Lind N.M. Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats. Behav Brain Funct 2008, 4:49.
38. Parasrampuria D.A., Schoedel K.A., Schuller R., Gu J., Ciccone P., Silber S.A., et al. Assessment of pharmacokinetics and pharmacodynamic effects related to abuse potential of a unique oral osmotic-controlled extended-release methylphenidate formulation in humans. J Clin Pharmacol 2007, 47:1476-1488.
39. Parasrampuria D.A., Schoedel K.A., Schuller R., Silber S.A., Ciccone P.E., Gu J., et al. Do formulation differences alter abuse liability of methylphenidate? A placebo-controlled, randomized, double-blind, crossover study in recreational drug users. J Clin Psychopharmacol 2007, 27:459-467.
40. Paulson P.E., Camp D.M., Robinson T.E. Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats. Psychopharmacology (Berl) 1991, 103:480-492.
41. Pelham W.E., Gnagy E.M., Burrows-Maclean L., Williams A., Fabiano G.A., Morrisey S.M., et al. Once-a-day Concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settings. Pediatrics 2001, 107:E105.
42. Poulin C. From attention-deficit/hyperactivity disorder to medical stimulant use to the diversion of prescribed stimulants to non-medical stimulant use: connecting the dots. Addiction 2007, 102:740-751.
43. Robinson T.E., Berridge K.C. Incentive-sensitization and addiction. Addiction 2001, 96:103-114.
44. Schmitz M., Cadore L., Paczko M., Kipper L., Chaves M., Rohde L.A., et al. Neuropsychological performance in DSM-IV ADHD subtypes: an exploratory study with untreated adolescents. Can J Psychiatry 2002, 47:863-869.
45. Schubiner H. Substance abuse in patients with attention-deficit hyperactivity disorder: therapeutic implications. CNS Drugs 2005, 19:643-655.
46. Schultz W. Predictive reward signal of dopamine neurons. J Neurophysiol 1998, 80:1-27.
47. Segovia G., Del A.A., Mora F. Environmental enrichment, prefrontal cortex, stress, and aging of the brain. J Neural Transm 2009, 116:1007-1016.
48. Sellings L.H., McQuade L.E., Clarke P.B. Characterization of dopamine-dependent rewarding and locomotor stimulant effects of intravenously-administered methylphenidate in rats. Neuroscience 2006, 141:1457-1468.
49. Shalev U., Grimm J.W., Shaham Y. Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol Rev 2002, 54:1-42.
50. Solinas M., Thiriet N., El R.R., Lardeux V., Jaber M. Environmental enrichment during early stages of life reduces the behavioral, neurochemical, and molecular effects of cocaine. Neuropsychopharmacology 2009, 34:1102-1111.
51. Spear L.P., Brake S.C. Periadolescence: age-dependent behavior and psychopharmacological responsivity in rats. Dev Psychobiol 1983, 16:83-109.
52. Thanos P.K., Michaelides M., Benveniste H., Wang G.J., Volkow N.D. Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents. Pharmacol Biochem Behav 2007, 87:426-433.
53. Valvassori S.S., Frey B.N., Martins M.R., Reus G.Z., Schimidtz F., Inacio C.G., et al. Sensitization and cross-sensitization after chronic treatment with methylphenidate in adolescent Wistar rats. Behav Pharmacol 2007, 18:205-212.
54. Vanderschuren L.J., Schoffelmeer A.N., Mulder A.H., De Vries T.J. Dopaminergic mechanisms mediating the long-term expression of locomotor sensitization following pre-exposure to morphine or amphetamine. Psychopharmacology (Berl) 1999, 143:244-253.
55. Vezina P., Lorrain D.S., Arnold G.M., Austin J.D., Suto N. Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine. J Neurosci 2002, 22:4654-4662.
56. Volkow N.D., Wang G.J., Fowler J.S., Ding Y.S. Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder. Biol Psychiatry 2005, 57:1410-1415.
57. Wenk G.L. Assessment of spatial memory using the T maze. Curr Protoc Neurosci 2001, Chapter 8: Unit.
58. Wiley M.D., Poveromo L.B., Antapasis J., Herrera C.M., Bolanos Guzman C.A. Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate. Neuropsychopharmacology 2009, 34:1339-1350.
59. Wolraich M.L., Doffing M.A. Pharmacokinetic considerations in the treatment of attention-deficit hyperactivity disorder with methylphenidate. CNS Drugs 2004, 18:243-250.
60. Yang P.B., Swann A.C., Dafny N. Chronic methylphenidate modulates locomotor activity and sensory evoked responses in the VTA and NAc of freely behaving rats. Neuropharmacology 2006, 51:546-556.
61. Zhuang X., Oosting R.S., Jones S.R., Gainetdinov R.R., Miller G.W., Caron M.G., et al. Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proc Natl Acad Sci USA 2001, 98:1982-1987.