Class Pi glutathione transferase unfolds via a dimeric and not monomeric intermediate: Functional implications for an unstable monomer

Biochemistry

Volumn 49, Issue 24, 2010, Pages 5074-5081

  Gildenhuys, Samantha ^a   Wallace, Louise A ^a   Burke, Jonathan P ^a   Balchin, David ^a   Sayed, Yasien ^a   Dirr, Heini W ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC; C-JUN N-TERMINAL KINASE; CATALYTIC FUNCTIONALITIES; CONFORMATIONAL STABILITIES; CYTOSOLIC; DIMERIC STRUCTURE; DRUG RESISTANCE; GLUTATHIONE TRANSFERASE; INTRINSIC STABILITY; MONOMERIC FORMS; MONOMERIC INTERMEDIATE; PROTEIN KINASE; UNFOLDING KINETICS; WILD TYPES; WILD-TYPE PROTEINS;

DETOXIFICATION; PROTEINS;

MONOMERS;

GLUTATHIONE TRANSFERASE P1; MONOMER;

ARTICLE; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN FOLDING;

ENZYME STABILITY; GLUTATHIONE S-TRANSFERASE PI; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; THERMODYNAMICS;

EID: 77953654496     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100552d     Document Type: Article

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