Angiogenic blockade and radiotherapy in hepatocellular carcinoma

International Journal of Radiation Oncology Biology Physics

Volumn 78, Issue 1, 2010, Pages 188-193

  Chi, Kwan Hwa ^a,b   Liao, Chao Sheng ^a   Chang, Chih Chia ^a   Ko, Hui Ling ^a   Tsang, Yuk Wah ^a   Yang, Kuo Ching ^a   Mehta, Minesh P ^c  

^a Shin Kong Memorial Hospital   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Antiangiogenic; Hepatocellular carcinoma; Radiotherapy; Sunitinib; Tomotherapy

Indexed keywords

ACUTE TOXICITY; ANTIANGIOGENIC; CONTROL GROUPS; DISEASE PROGRESSION; EVALUATION CRITERIA; FETOPROTEIN; HELICAL TOMOTHERAPY; HEPATIC LESIONS; HEPATOCELLULAR CARCINOMA; HIGH RESPONSE; MEDIAN SURVIVAL; MEDIAN TARGET; MULTI VARIATE ANALYSIS; RADIATION THERAPY; RADIOLOGIC RESPONSE; RANDOMIZED TRIAL; RESPONSE RATE; SIGNIFICANT FACTORS; SOLID TUMORS; SUNITINIB; SURVIVAL RATE; THROMBOCYTOPENIA; TOMOTHERAPY; UPPER GASTROINTESTINAL;

MULTIVARIANT ANALYSIS; RADIOTHERAPY;

MAINTENANCE;

ALPHA FETOPROTEIN; ANGIOGENESIS INHIBITOR; SUNITINIB;

ADULT; AGED; ANTIANGIOGENIC THERAPY; ARTICLE; CANCER GROWTH; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; FATIGUE; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; LIVER CELL CARCINOMA; MAINTENANCE THERAPY; MALE; NAUSEA; PANCREATITIS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SIDE EFFECT; SURVIVAL RATE; THROMBOCYTOPENIA; TOMOTHERAPY;

ADULT; AGED; ALPHA-FETOPROTEINS; ANALYSIS OF VARIANCE; ANGIOGENESIS INHIBITORS; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; COMBINED MODALITY THERAPY; DOSE FRACTIONATION; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMANS; INDOLES; LIVER NEOPLASMS; MALE; MIDDLE AGED; PYRROLES; RADIOTHERAPY, INTENSITY-MODULATED; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 77953653712     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.07.1725     Document Type: Article

References (34)

1. X.D. Zhou, Z.Y. Tang, and B.H. Yang Experience of 1000 patients who underwent hepatectomy for small hepatocellular carcinoma Cancer 91 2001 1479 1486
2. J.H. Wang, C.S. Changchien, and T.H. Hu The efficacy of treatment schedules according to Barcelona Clinic Liver Cancer staging for hepatocellular carcinoma: Survival analysis of 3892 patients Eur J Cancer 44 2008 1000 1006
3. K. Takayasu, S. Arii, and I. Ikai Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients Gastroenterology 131 2006 461 469
4. J.M. Llovet, and J. Bruix Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival Hepatology 37 2003 429 442
5. R.V. Tse, C. Guha, and L.A. Dawson Conformal radiotherapy for hepatocellular carcinoma Crit Rev Oncol Hematol 67 2008 113 123
6. J.W. Ho, R.W. Pang, and C. Lau Significance of circulating endothelial progenitor cells in hepatocellular carcinoma Hepatology 44 2006 836 843
7. A.X. Zhu, D.V. Sahani, and E. di Tomaso A phase II study of sunitinib in patients with advanced hepatocellular carcinoma [Abstract] J Clin Oncol 25 Suppl 2007 231s-231s
8. G.K. Abou-Alfa, L. Schwartz, and S. Ricci Phase II study of sorafenib in patients with advanced hepatocellular carcinoma J Clin Oncol 24 2006 4293 4300
9. S.J. Faivre, E. Raymond, and J. Douillard Assessment of safety and drug-induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC) [Abstract] J Clin Oncol 25 Suppl 2007 3546s-3546s
10. J.M. Llovet, S. Ricci, and V. Mazzaferro Sorafenib in advanced hepatocellular carcinoma N Engl J Med 359 2008 378 390
11. A.L. Cheng, Y.K. Kang, and Z. Chen Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial Lancet Oncol 10 2009 25 34
12. K.C. Cuneo, L. Geng, and A. Fu SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation Int J Radiat Oncol Biol Phys 71 2008 873 879
13. D.G. Duda, R.K. Jain, and C.G. Willett Antiangiogenics: The potential role of integrating this novel treatment modality with chemoradiation for solid cancers J Clin Oncol 25 2007 4033 4042
14. A.J. Schueneman, E. Himmelfarb, and L. Geng SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models Cancer Res 63 2003 4009 4016
15. P. Therasse, S.G. Arbuck, and E.A. Eisenhauer New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst 92 2000 205 216
16. Y.Q. Yu, D.B. Xu, and X.D. Zhou Experience with liver resection after hepatic arterial chemoembolization for hepatocellular carcinoma Cancer 71 1993 62 65
17. T. Higuchi, M. Kikuchi, and M. Okazaki Hepatocellular carcinoma after transcatheter hepatic arterial embolization: A histopathologic study of 84 resected cases Cancer 73 1994 2259 2267
18. J. Seong, H.C. Park, and K.H. Han Clinical results and prognostic factors in radiotherapy for unresectable hepatocellular carcinoma: A retrospective study of 158 patients Int J Radiat Oncol Biol Phys 55 2003 329 336
19. Z.C. Zeng, Z.Y. Tang, and J. Fan A comparison of chemoembolization combination with and without radiotherapy for unresectable hepatocellular carcinoma Cancer J 10 2004 307 316
20. D.H. Wu, L. Liu, and L.H. Chen Therapeutic effects and prognostic factors in three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for hepatocellular carcinoma World J Gastroenterol 10 2004 2184 2189
21. W.J. Guo, E.X. Yu, and L.M. Liu Comparison between chemoembolization combined with radiotherapy and chemoembolization alone for large hepatocellular carcinoma World J Gastroenterol 9 2003 1697 1701
22. T.H. Kim, D.Y. Kim, and J.W. Park Three-dimensional conformal radiotherapy of unresectable hepatocellular carcinoma patients for whom transcatheter arterial chemoembolization was ineffective or unsuitable Am J Clin Oncol 29 2006 568 575
23. T. Chiba, K. Tokuuye, and Y. Matsuzaki Proton beam therapy for hepatocellular carcinoma: A retrospective review of 162 patients Clin Cancer Res 11 2005 3799 3805 (Pubitemid 40685599)
24. J. Jeong Won, K. Chul Seung, and Y. Chan Ran Simultaneous multitarget irradiation using helical tomotherapy for advanced hepatocellular carcinoma with multiple extrahepatic metastases Int J Radiat Oncol Biol Phys 74 2009 412 418
25. A.M. Shannon, and K.J. Williams Antiangiogenics and radiotherapy J Pharm Pharmacol 60 2008 1029 1036
26. Y.L. Chung, J.J. Jian, and S.H. Cheng Sublethal irradiation induces vascular endothelial growth factor and promotes growth of hepatoma cells: Implications for radiotherapy of hepatocellular carcinoma Clin Cancer Res 12 2006 2706 2715
27. R.T. Poon, C. Lau, and R. Pang High serum vascular endothelial growth factor levels predict poor prognosis after radiofrequency ablation of hepatocellular carcinoma: Importance of tumor biomarker in ablative therapies Ann Surg Oncol 14 2007 1835 1845
28. C.H. Chou, P.J. Chen, and P.H. Lee Radiation-induced hepatitis B virus reactivation in liver mediated by the bystander effect from irradiated endothelial cells Clin Cancer Res 13 2007 851 857
29. J.H. Kim, J.W. Park, and T.H. Kim Hepatitis B virus reactivation after three-dimensional conformal radiotherapy in patients with hepatitis B virus-related hepatocellular carcinoma Int J Radiat Oncol Biol Phys 69 2007 813 819
30. J.C. Cheng, J.K. Wu, and P.C. Lee Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease Int J Radiat Oncol Biol Phys 60 2004 1502 1509
31. R.P. Dings, M. Loren, and H. Heun Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization Clin Cancer Res 13 2007 3395 3402
32. M.R. Mancuso, R. Davis, and S.M. Norberg Rapid vascular regrowth in tumors after reversal of VEGF inhibition J Clin Invest 116 2006 2610 2621
33. R.K. Jain Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy Science 307 2005 58 62
34. F. Winkler, S.V. Kozin, and R.T. Tong Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases Cancer Cell 6 2004 553 563