Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin

Journal of Natural Medicines

Volumn 64, Issue 3, 2010, Pages 388-391

  Yasukawa, Ken ^a   Matsubara, Hideki ^a   Sano, Yuri ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Artichoke; Cancer chemoprevention; Cynara cardunculus; Two stage carcinogenesis

Indexed keywords

ALPHA AMYRIN; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; BETA AMYRIN; CYNARA CARDUNCULUS EXTRACT; INDOMETACIN; METHANOL; PHORBOL 13 ACETATE 12 MYRISTATE; PLANT EXTRACT; PSI TAXASTEROL; PSI TAXASTEROL ACETATE; TARAXASTEROL; TARAXASTEROL ACETATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CARDOON; CHEMOPROPHYLAXIS; EDEMA; FEMALE; FLOWER; MOUSE; NONHUMAN; SKIN CARCINOGENESIS;

ACETATES; ALCOHOLS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CYNARA SCOLYMUS; FEMALE; FLOWERS; INFLAMMATION; MICE; MICE, INBRED ICR; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TRITERPENES;

EID: 77953649283     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-010-0403-z     Document Type: Article

References (15)

1. KriẑkováL, Muĉaji PM, Nagy M, Krajĉoviĉ J (2004) Triterpenoid cynarasaponins from Cynara cardunculus L. reduce chemically induced mutagenesis in vitro. Phytomedicine 11:673-678
2. Akihisa T, Yasukawa K (2001) Antitumor-promoting and antiinflammatory activities of triterpenoids and sterols from plants and fungi. In: Atta-ur-Rahman (ed) Studies in natural product chemistry. Bioactive natural products. Part F, vol 25. Elsevier Science, Amsterdam, pp 43-87
3. Akihisa T, Yasukawa K, Tokuda H (2003) Potentially cancer chemopreventive and anti-inflammatory terpenoids from natural sources. In: Atta-ur-Rahman (ed) Studies in natural product chemistry. Bioactive natural products. Part J, vol 29. Elsevier Science, Amsterdam, pp 73-136
4. Akihisa T, Oinuma H, Yasukawa K, Kasahara Y, Kimura Y, Takase S, Tamanouchi S, Takido M, Kumaki K, Tamura T (1996) Helianol [3,4-seco-19(10 → 9)abeo-8a,9b,10a-eupha-4,24-dien- 3-ol], a novel triterpene alcohol from the tabular flowers of Helianthus annuus L. Chem Pharm Bull (Tokyo) 44:1255-1257
5. Yasukawa K, Akihisa T, Oinuma H, Kasahara Y, Kimura Y, Yamanouchi S, Kumaki K, Tamura T, Takido M (1996) Inhibitory effect of di- and trihydroxy triterpenes from the flowers of Compositae on 12-O-tetradecanoylphorbol-13- acetate-induced inflammation in mice. Biol Pharm Bull (Tokyo) 19:1329-1331
6. Akihisa T, Yasukawa K, Oinuma H, Kasahara Y, Yamanouchi S, Takido M, Kumaki K, Tamura T (1996) Triterpene alcohols from the flowers of Compositae and their anti-inflammatory effects. Phytochemistry 43:1255-1260
7. Yu S, Yasukawa K, Takido M (1994) Atractylodis Rhizoma extract and its component, atractylon, inhibit tumor promotion in mouse skin two-stage carcinogenesis. Phytomedicine 1:55-58
8. Kasahara Y, Kumaki K, Katagiri S, Yasukawa K, Yamanouchi S, Takido M, Akihisa T, Tamura T (1994) Carthami Flos extract and its component, stigmasterol, inhibit tumor promotion in mouse skin two-stage carcinogenesis. Phytother Res 8:327-331
9. Takasaki M, Konoshima T, Tokuda H, Masuda K, Arai Y, Shiojima K, Ageta H (1999) Anti-carcinogenic activity of Taraxacum plant. I. Biol Pharm Bull 22:602-605
10. Yasukawa K, Takido M, Takeuchi M, Nakagawa S (1989) Effect of chemical constituents from plants on 12-O-tetradecanoylphorbol- 13-acetate-induced inflammation in mice. Chem Pharm Bull 37:1071-1073
11. Yasukawa K, Akihisa T, Oinuma H, Kaminaga T, Kanno H, Kasahara Y, Tanuma T, Kumaki K, Yamanouchi S, Takido M (1996) Inhibitory effect of taraxastane-type triterpenes on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology 53:341-344 (Pubitemid 26237230)
12. Takasaki M, Konoshima T, Tokuda H, Masuda K, Arai Y, Shiojima K, Ageta H (1999) Anti-carcinogenic activity of Taraxacum plant. II. Biol Pharm Bull 22:606-610
13. Vitor CE, Figueiredo CP, Hara DB, Bento AF, Mazzuco TL, Calixto JB (2009) Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, a- and b-amyrin, in a mouse model of colitis. Br J Pharmacol 157:1034-1044
14. Medeiros R, Otuki MF, Avellar MCW, Calixto JB (2007) Mechanisms underlying the inhibitory actions of the pentacyclic triterpene a-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13- acetate. Eur J Pharmacol 559:227-235
15. Ding Y, Nguyen HT, Kim SI, Kim HW, Kim YH (2009) The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris. Bioorg Med Chem Lett 19:3607-3610