Triterpenoid cynarasaponins from Cynara cardunculus L. reduce chemically induced mutagenesis in vitro

Phytomedicine

Volumn 11, Issue 7-8, 2004, Pages 673-678

  Krizkova L ^a   Mucaji P ^a   Nagy, M ^a   Krajcovic J ^a  

^a Physics and Informatics   (Slovakia)

Author keywords

Acridine orange; Antimutagenicity; Cynarasaponins; Euglena gracilis; Ofloxacin

Indexed keywords

ACRIDINE ORANGE; CHLOROPLAST DNA; CYNARA CARDUNCULUS EXTRACT; CYNARASAPONIN; OFLOXACIN; PLANT EXTRACT; TRITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; CARDOON; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; DNA DAMAGE; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; EUGLENA GRACILIS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

CYNARA CARDUNCULUS; EUGLENA GRACILIS; MASTIGOPHORA (FLAGELLATES);

EID: 10844239135     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2003.09.001     Document Type: Article

References (29)

1. Bader, G., Hiller, K., 1987. New findings on the structure and biological activity of triterpene saponins. Pharmazie 42, 577-597.
2. Cramer, M., Myers, J., 1952. Growth and photosynthetic characteristic of Euglena gracilis. Arch. Microbiol. 17, 384-402.
3. Ebringer, L., Dobias, J., Krajčovič, J., Polónyi, J., Križková, L., Lahitová, N., 1996. Antimutagens reduce ofloxacin-induced bleaching in Euglena gracilis. Mutat. Res. 359, 85-93.
4. Elias, R., De Meo, M., Vidal-Ollivier, E., Laget, M., Balansard, G., Cumenil, G., 1990. Antimutagenic activity of some saponins isolated from Calendula officinalis L., C. arvensis L., and Hedera helix L. Mutagenesis 5, 327-331.
5. Ferguson, L.R., Denny, W.A., 1991. The genetic toxicology of acridines. Mutat. Res. 258, 123-160.
6. Hooper, D.C., Wolfson, J.S., 1993. Mechanisms of quinolone action and bacterial killing. In: Hooper, D.C., Wolfson, J.S. (Eds.), Quinolone Antimicrobial Agents, Second ed.. American Society for Microbiology, Washington, DC, pp. 53-75.
7. Hostettmann, K., Marston, A., 1995. Saponins. Cambridge University Press.
8. Khalil, A.H., El-Adaway, T.A., 1994. Isolation, identification and toxicity of saponins from different legumes. Food Chem. 50, 197-201.
9. Kim, S.E., Leem, Y.H., Park, J.H., Lee, S.K., 1999. Ginsenoside-Rs(3), a new diol-type ginseng saponin, selectively elevates protein level of p53 and p21 (WAF1) leading to induction of apoptosis in SK-HEP-1 cells. Anticancer Res. 19, 487-491.
10. Konoshima, T., Kokumai, M., Kozuka, M., Tokudam, H., Nishio, H., Iwashima, A., 1992. Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys. J. Nat. Prod. 55, 1776-1778.
11. Koratker, R., Rao, A.V., 1997. Effect of soya bean saponins on azoxymethane-induced preneoplastic lesion in colon of mice. Nutr. Cancer 27, 206-209.
12. Krajcovic, J., Ebringer, L., Schwartzbach, S.D., 2001. Reversion of endosymbiosis? The case of bleaching in Euglena. In: Seckbach, J. (Ed.), Symbiosis. Kluwer Academic Publishers, The Netherlands, pp. 185-206.
13. Križkova, L., Horniak, L., Sláviková, S., Ebringer, L., 1996. Protective effects of sodium selenite on ofloxacin-induced loss of chloroplast DNA in Euglena gracilis. Folia Microbiol. 41, 329-332.
14. Križková, L., Nagy, M., Polónyi, J., Ebringer, L., 1998. The effect of flavonoids on ofloxacin-induced mutagenicity in Euglena gracilis. Mutat. Res. 416, 85-92.
15. Križkova, L., Lopes, M.H., Polónyi, J., Belicová, A., Dobias, J., Ebringer, L., 1999. Antimutagenicity of a suberin extract from Quercus suber cork. Mutat. Res. 446, 225-230.
16. Križková, L., Polónyi, J., Košiková, B., Dobias, J., Belicová, A., Krajčovič, J., Ebringer, L., 2000a. Lignin reduces ofloxacin-induced mutagenicity in Euglena assay. Anticancer Res. 29, 833-836.
17. Križková, L., Nagy, M., Polónyi, J., Dobias, J., Belicová, A., Grančai, D.; Krajčovič, J., 2000b. Phenolic acid inhibit chloroplast mutagenesis in Euglena gracilis. Mutat. Res. 469, 107-114.
18. Križková, L., Ďuračková, Z., Šandula, J., Sasinková, V., Krajčovič, J., 2001. Antioxidative and antimutagenic activity of yeast cell wall mannans in vitro. Mutat. Res. 497, 213-222.
19. Lacaille-Dubois, M.A., Wagner, H., 1996. A review of the biological and pharmacological activities of saponins. Phytomedicine 2, 363-386.
20. Mučaji, P., Grančai, D., Nagy, M., Buděš insky, M., Ubik, K., 1999. Triterpenoid saponins from Cynara cardunculus L. Pharmazie 54, 714-716.
21. Mučaji, P., Grančai, D., Nagy, M., Buděš insky, M., Ubik, K., 2001. Monodesmosidic saponins from Cynara cardunculus L. Čes. slov. Farm. 50, 277-279.
22. Okubo, K., Kudou, S., Uchida, T., Yoshiki, Y., Yoshikoshi, M., Tonomura, M., 1994. Soybean saponin isoflavonoids: structure and antiviral activity against human immunodeficiency virus in vitro. In: Huang, M.T., Osawa, T., Ho, T.C., Rosen, R.T. (Eds.), Food phytochemicals for cancer protection I: Fruits and Vegetables. American Chemical Society, Washington, DC, pp. 330-339.
23. Oshite, H., Oda, M., Nguyen, V.C., 1996. Desmutagenicity of soybean after heating. Biosci. Biotechnol. Biochem. 60, 1152-1155.
24. Rao, A.V., Sung, M.K., 1995. Saponins as anticarcinogens. J. Nutr. 125, 717S-724S.
25. Sugano, M., Goto, S., Yamada, Y., Yoshida, K., Hashimoto, Y., Matsuo, T., Kimoto, T., 1990. Cholesterol-lowering activity of various undigested fractions of soybean protein in rats. J. Nutr. 120, 977-985.
26. Sung, M.K., Kendall, C.W.C., Rao, A.V., 1995. Effect of soybean saponins on morphology of colon carcinoma cells in culture. Food Chem. Toxicol. 33, 357-366.
27. Umezawa, N., Arakane, K., Ryu, A., Matshiko, S., Hirobe, N., Nagano, T., 1997. Participation of reactive oxygen species in photoxicity induced by quinolone antibacterial agents. Arch. Biochem. Biophys. 342, 275-281.
28. Yoshiki, Y., Kinumi, M., Kahara, T., Okubo, K., 1996. Chemiluminescence of soybean saponins in the presence of active oxygen species. Plant. Sci. 116, 125-129.
29. Yoshiki, Y., Kudou, S., Okubo, K., 1998. Relationship between chemical structures and biological activities of triterpenoid saponins from soybean. Biosci. Biotechnol. Biochem. 62, 2291-2299.