Assessing medication exposures and outcomes in the frail elderly: Assessing research challenges in nursing home pharmacotherapy

Medical Care

Volumn 48, Issue 6 SUPPL., 2010, Pages

  Crystal, Stephen ^a   Gaboda, Dorothy ^a,b   Lucas, Judith ^a   Gerhard, Tobias ^a,c   Chakravarty, Sujoy ^a,c  

^a The State University of New Jersey   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL ASSESSMENT; DRUG EXPOSURE; ELECTRONIC MEDICAL RECORD; FRAIL ELDERLY; HEALTH CARE FACILITY; INSURANCE; MEDICAID; MEDICARE; NURSING HOME; PRESCRIPTION; PRIORITY JOURNAL; REVIEW; TREATMENT OUTCOME; AGE; AGED; ARTICLE; COMPARATIVE EFFECTIVENESS; DRUG UTILIZATION; EPIDEMIOLOGY; HOME FOR THE AGED; HUMAN; INFORMATION PROCESSING; METHODOLOGY; SEX; SOCIOECONOMICS; STATISTICS; UNITED STATES;

PRESCRIPTION DRUG;

AGE FACTORS; AGED; COMPARATIVE EFFECTIVENESS RESEARCH; CONFOUNDING FACTORS (EPIDEMIOLOGY); DATA COLLECTION; DRUG UTILIZATION; HOMES FOR THE AGED; HUMANS; INSURANCE CLAIM REVIEW; MEDICAID; MEDICARE PART D; NURSING HOMES; PRESCRIPTION DRUGS; RESEARCH DESIGN; SEX; SOCIOECONOMIC FACTORS; UNITED STATES;

EID: 77953643851     PISSN: 00257079     EISSN: None     Source Type: Journal    
DOI: 10.1097/MLR.0b013e3181de9d10     Document Type: Review

References (45)

1. Avorn J. Powerful Medicines: The Benefits, Risks, and Costs of Prescription Drugs. New York: Vintage Books; 2005.
2. Kaufman DW, Kelly JP, Rosenberg L, et al. Recent patterns of medication use in the ambulatory adult population of the US: The Slone Survey. JAMA. 2002;287:337-344.
3. Simoni-Wastila L, Stuart BC, Shaffer T. Over-the-counter drug use by Medicare beneficiaries in nursing homes: implications for practice and policy. J Am Geriatr Soc. 2006;54:1543-1549.
4. Schneider LS, Olin JT, Lyness SA, et al. Eligibility of Alzheimer's disease clinic patients for clinical trials. J Am Geriatr Soc. 1997;45:923-928.
5. Gurwitz JH, Field TS, Avorn J, et al. Incidence and preventability of adverse drug events in nursing homes. Am J Med. 2000;109:87-94.
6. Lau D, Kasper J, Potter DEB, et al. HSR: Health Serv Res. 2004;39: 1257-1276.
7. Jeste DV, Blazer D, Casey D, et al. ACNP white paper: Update on use of antipsychotic drugs in elderly persons with dementia. Neuropsychopharmacology. 2008;33:957-970.
8. Schneeweiss S, Setoguchi S, Brookhart A, et al. Risk ofdeath associated with the use of conventional versus atypical antipsychotic drugs among elderly patients. CMAJ. 2007;176:627-632.
9. Wang PS, Schneeweiss S, Avorn J, et al. Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Engl J Med. 2005;353:2335-2341.
10. Harrington C, Carrillo H, LaCava C. Nursing Facilities, Staffing, Residents, and Facility Deficiencies, 1999 Through 2005. San Francisco, CA: Department of Social and Behavioral Sciences, University of California; 2006.
11. The Henry J. Kaiser Family Foundation. The Medicare Prescription Drug Benefit. Fact sheet #7044-10. 2009. Available at: http://www.kff.org. Accessed April 6, 2010.
12. Briesacher BA, Soumerai SB, Field TS, et al. Nursing home residents and enrollment in Medicare Part D. J Am Geriatr Soc. 2009;57:1902-1907.
13. Centers for Medicare and Medicaid Services. Interpretive guidelines for long-term facilities. In: State Operations Manual. Available at: http://www.cms.hhs.gov/SurveyCertificationGenInfo/. Accessed November 20, 2009.
14. Centers for Medicare and Medicaid Services. 2004. Revised Long-Term Care Facility Resident Assessment Instrument User's Manual. Version 2.0; 2008. Available at: http://www.cms.hhs.gov/MinimumDataSets20/025-ManualsAndForms.asp. Accessed November 20, 2009.
15. Mor V. A comprehensive clinical assessment tool to inform policy and practice: Applications of the Minimum Data Set. Med Care. 2004;42: 50-59.
16. Gruber-Baldini AL, Zimmerman SI, Mortimore E, et al. The validity of the Minimum Data Set in measuring the cognitive impairment ofpersons admitted to nursing homes. J Am Med Dir Assoc. 2000;48:1601-1606.
17. Mor V, Angelelli J. Jones R, et al. Inter-rater reliability of nursing home quality indicators in the US. BMC Health Serv Res. 2003;3:20.
18. Hawes C, Morris JN, Phillips CD, et al. Reliability estimates for the Minimum Data Set for nursing home resident assessment and care screening (MDS). Gerontologist. 1995;35:172-178.
19. Liperoti R, Pedrone C, Lapane K, et al. Venous thromboembolism among elderly patients treated with atypical and conventional antipsychotic agents. Arch Intern Med. 2005;165:2677-2682. (Pubitemid 41785068)
20. Liperoti R, Gambassi G, Lapane KL, et al. Conventional and atypical antipsychotics and the risk of hospitalization for ventricular arrhythmias or cardiac arrest. Arch Intern Med. 2005;165:696-701.
21. Jalbert J, Eaton C, Miller S, Lapane K. Antipsychotic use and the risk of hip fracture among older adults afflicted with dementia. J Am Med Dir Assoc. 2010;11:120-127.
22. Saliba D, Buchanan J. Development & Validation of a Revised Nursing Home Assessment Tool: MDS 3.0; 2008. Available at: http://cms.hhs. gov/NursingHomeQualityInits. Accessed December 13, 2009.
23. Harrington C, Zimmerman D, Karon SL, et al. Nursing home staffing and its relationship to deficiencies. J Gerontol Soc Sci. 2000;55B:S278-S287.
24. Feng Z, Katz PR, Intrator O, et al. Physician and nurse staffing in nursing homes: The role and limitations of the Online Survey Certification and Reporting (OSCAR) system. J Am Med Dir Assoc. 2005;6:27-33.
25. Lapane KL, Hughes CM. Which organizational characteristics are associated with increased management ofdepression using antidepressants in US nursing homes? Med Care. 2004;42:992-1000.
26. Levin CA, Wei W, Akincigil A, et al. Prevalence and treatment of diagnosed depression among elderly nursing home residents in Ohio. J Am Med Dir Assoc. 2007;8:585-594.
27. Mor V, Berg K, Angelelli J, et al. The quality of quality measurement in US nursing homes. Gerontologist. 2003;43:37-46.
28. O'Neill C, Harrington C, Kitchener M, et al. Quality of care in nursing homes: An analysis of relationships among profit, quality, and ownership. Medical Care. 2003;41:1318-1330.
29. Hughes CM, Lapane KL, Mor V. Influence of facility characteristics on use of antipsychotic medications in nursing homes. Med Care. 2000;38: 1164-1173.
30. Gerhard T, Lucas JA, Olfson M, et al. Effect of regulatory warnings on antipsychotic prescribing for nursing home residents with dementia. PDS Pharmacoepidemiol Drug Saf. 2008;17:S120-S121.
31. Intrator O, Castle NG, Mor V. Facility characteristics associated with hospitalization of nursing home residents: Results of a national study. Med Care. 1999;37:228-237.
32. Crystal S, Akincigil A, Bilder S, et al. Studying prescription drug use and outcomes with Medicaid claims data: strengths, limitations, and strategies. Med Care. 2007;45:S58-S65.
33. Gruneir A, Miller SC, Feng Z, et al. Relationship between state Medicaid policies, nursing home racial composition, and the risk of hospitalization for black and white residents. Health Serv Res. 2008;43:869-881.
34. Intrator O, Zinn J, Mor V. Nursing home characteristics and potentially preventable hospitalizations of long-stay residents. J Am Geriatr Soc. 2004;52:1730-1736.
35. Lapane KL, Spooner JJ, Mucha L, et al. Effect of nonsteroidal antiinflammatory drug use on the rate of gastrointestinal hospitalizations among people living in long-term care. J Am Geriatr Soc. 2001;49:577-584.
36. Quilliam BJ, Lapane KL. Clinical correlates and drug treatment of residents with stroke in long-term care. Stroke. 2001;32:1385-1393.
37. Lucas JA, Bowblis J, Gerhard T, Chakravarty S, Crystal S. Antipsychotic medication (APM) use among nursing home residents: Appropriate or Inappropriate? PDS: Pharmacoepidemiology Drug Saf. 2009;18:S143.
38. American Medical Directors Association. Clinical Practice Guidelines in the Long Term Care Setting. AMDA; 2003.
39. American Geriatrics Society (AGS) and American Association for Geriatric Psychiatry (AAGP). Consensus statement on improving the quality of mental health care in U.S. nursing homes: Management of depression and behavioral symptoms associated with dementia. J Am Geriatr Soc. 2003;51:1287-1298.
40. Shin JH, Scherer Y. Advantages and disadvantages of using MDS data in nursing research. J Gerontol Nurs. 2009;35:7-17.
41. Fisher SE, Burgio LD, Thorn BE, et al. Pain assessment and management in cognitively impaired nursing home residents: Association of certified nursing assistance pain report, Minimum Data Set pain report, and analgesic medication use. J Am Geriatr Soc. 2002;50: 152-156.
42. McCurran C. Assessment for depression among nursing home elders: Evaluation of the MDS mood assessment. Geriatr Nurs. 2002;23:103-108.
43. Engle VF, Graney MJ, Chan A. Accuracy and bias of licensed practical nurse and nursing assistant ratings of nursing home residents' pain. J Gerontol A Bio Sci Med Sci. 2001;56:M405-M411.
44. Bharucha AJ, Vasilescu M, Dew MA, et al. Prevalence of behavioral symptoms: comparison of the Minimum Data Set assessment with research instruments. J Am Med Dir Assoc. 2008;9:244-250.
45. Swanson MW. Care plan assessment for visual status and evaluated vision among nursing home residents. Optom Vis Sci. 1995;72:151-154.