Heparin and oversulfated heparin byproduct induce thrombin generation through contact system activation in plasma of patients with HIT

Clinical and Applied Thrombosis/Hemostasis

Volumn 16, Issue 3, 2010, Pages 251-260

  Qian, Yi ^a   Pan, Jing ^a   Zhou, Xiaodong ^a   Weiser, Peter ^a   Lu, Hong ^a   Shih, Fei F ^b   Porche Sorbet, Rhonda ^a   Eby, Charles ^a   Zhang, Lijuan ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

Contact system; Contaminated heparin; Heparin induced thrombocytopenia; Kallikrein; Thrombin

Indexed keywords

AUTOANTIBODY; FC RECEPTOR; HEPARIN; IMMUNOGLOBULIN G; THROMBIN; THROMBOCYTE FACTOR 4;

ADULT; AGED; ANAPHYLAXIS; ANIMAL CELL; ARTICLE; CLINICAL ARTICLE; DEATH; DRUG CONTAMINATION; FEMALE; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; INCIDENCE; LIMB AMPUTATION; MALE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STROKE; THROMBOCYTE ACTIVATION; THROMBOSIS;

ADULT; AGED; AGED, 80 AND OVER; ANAPHYLAXIS; ANIMALS; ANTICOAGULANTS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; CHO CELLS; CHONDROITIN SULFATES; CRICETINAE; CRICETULUS; DISEASE OUTBREAKS; DRUG CONTAMINATION; ENZYME ACTIVATION; FEMALE; HEPARIN; HUMANS; IMMUNOGLOBULIN G; KALLIKREINS; MALE; MIDDLE AGED; PLATELET ACTIVATION; PLATELET FACTOR 4; PREKALLIKREIN; PROTHROMBIN; THROMBIN; THROMBOCYTOPENIA;

EID: 77953641923     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/1076029610362072     Document Type: Article

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