Health-related quality of life, faecal continence and bowel function in rectal cancer patients after chemoradiotherapy followed by radical surgery

Supportive Care in Cancer

Volumn 18, Issue 5, 2010, Pages 601-608

  Pucciarelli, Salvatore ^a   Bianco, Paola Del ^b   Efficace, Fabio ^c   Toppan, Paola ^a   Serpentini, Samantha ^a   Friso, Maria Luisa ^b   Lonardi, Sara ^b   De Salvo, Gian Luca ^b   Nitti, Donato ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^c GIMEMA Data Centre   (Italy)

Author keywords

Bowel function; Chemoradiotherapy; Faecal incontinence; Health related quality of life; Rectal cancer

Indexed keywords

ENEMA; FLUOROURACIL; LAXATIVE;

AGED; ARTICLE; CANCER PATIENT; CANCER SURGERY; CANCER SURVIVOR; CONSTIPATION; CONTINUOUS INFUSION; CROSS-SECTIONAL STUDY; DEFECATION URGENCY; DIARRHEA; DISEASE ASSOCIATION; EXTERNAL BEAM RADIOTHERAPY; FECES ANALYSIS; FECES INCONTINENCE; FEMALE; HEALTH STATUS; HUMAN; INTESTINE FUNCTION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PREOPERATIVE PERIOD; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RECTUM CANCER; SOCIAL STATUS;

AGED; CHEMOTHERAPY, ADJUVANT; CROSS-SECTIONAL STUDIES; FECAL INCONTINENCE; FEMALE; HUMANS; ITALY; MALE; QUALITY OF LIFE; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS;

EID: 77953621046     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00520-009-0699-y     Document Type: Article

References (42)

1. National Comprehensive Cancer Network. Colon and RectalCancer. Treatment Guidelines for Patients. Version V /Octo ber2007. Last accessed June 2008. http://www.nccn.org/patients/default.asp
2. Sauer R, Becker H, Hohenberger W et al (2004) Preoperativeversus posto perative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731-1740
3. Bosset J-F, Collette L, Calaisg et al (2006) Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med355:1114-1123
4. Ǵrard J-P, Conroy T, Bonnetain F et al (2006) Preoperativeradiotherapy with or with out concurrent fluorouracil and leucovor in in T3-4 rectal cancer: Results of FFCD 9203. J Clinoncol24:4620-4625
5. Valentini V, Coco C, Cellini N et al (2001) Ten years of preoperativechemoradiation for extraperitoneal T3 rectal cancer: Acute to xicity,tumour response, and sph in cter preservation in three consecutivestudies. in t J Radiationoncology Biol Phys 5:371-383
6. Pucciarelli S, to ppan P, Friso ML et al (2004) Completepathologic response follow ing preoperative chemoradiation therapyfor middle to lower rectal cancer is not a prognostic facto r fora better outcome. Dis Colon Rectum 47:1798-1807
7. Bujko K, Nowacki MP, Nasierowska-Guttmejer A et al (2006) Long-term results of a randomized trial compar ing preoperativeshort-course radiotherapy with preoperative conventionally fractionatedchemoradiation for rectal cancer. Br J Surg 93:1215-1223
8. Sauer R, Fietkau R, Wittekind C et al (2003) Adjuvant vs.neoadjuvant radiochemotherapy for locally advanced rectalcancer: The German trial CAO/ARO/AIO-94. Colorectal Dis5:406-415
9. Pietrza K L, Mujko K, Novacki MP et al (2007) Quality of life,anorectal and sexual functions after preoperative radiotherapy forrectal cancer: Report of a randomized trial. Radiother Oncol84:217-225
10. Gervaz P, Wexner SD, Pemberton JH (2002) Pelvic radiation andanorectal function: In troduc ing the concept of sph in cterpreserv in gradiation therapy. J Am Coll Surg 195:387-394
11. Marijnem CAM, van de Velde CJH, Putter H et al (2005) Impact of short-term preoperative radiotherapy on health-related quality of life and sexual function ing in primary rectal cancer: Report of amulticenter randomized trial. J Clinoncol 23:1847-1858
12. Peeters KC, van de Velde CJ, Leer JW et al (2005) Late sideeffects of short-course preoperative radiotherapy comb in ed with to tal mesorectal excision for rectal cancer: Increased boweldysfunction in irradiated patients-A Dutch colorectal cancergroup study. J Clinoncol 23:6199-6206
13. Guren MG, Eriksen MT, Wiig JN et al (2005) Quality of life andfunctional outcome follow ing anterior or abdom inoper in ealresection for rectal cancer. Eur J Surg Oncol 31:735-742
14. Hassan I, Larson DW, Cima RR et al (2006) Long-term functionaland quality of life outcomes after coloanal anasto mosis for distalrectal cancer. Dis Colon Rectum 49:1266-1274
15. Hendren SK, O'Connor BI, Liu M et al (2005) Prevalence of maleand female sexual dysfunction is high follow ing surgery for rectalcancer. Ann Surg 242:212-223
16. Engel J, Kerr J, Schleisinger-Racib A et al (2003) Quality of life in rectal cancer patients: A four-year prospective study. Ann Surg238:203-213 (Pubitemid 38174494)
17. Rauch P, Miny J, Conroy T, Neyton L, Guillermin F (2004) Quality of life among disease-free survivors of rectal cancer. J Clinoncol 22:354-360
18. Neuman HB, Schrag D, Cabral C et al (2007) Can differences in bowel function after surgery for rectal cancer be identified by the Europeanorganization for research and treatment of cancer quality of life in struments? Ann Surg Oncol 14:1727-1734
19. Langenhoff BS, Krabbe PFM, Wobbes T, Ruer TJM (2001) Quality of life as anoutcome measure in surgical oncology. Br J Surg 88:643-652
20. Blazeby JM, Avery K, Sprangers M et al (2006) Health-relatedquality of life measurement in randomized clin ical trials in surgical oncology. J Clinoncol 24:3178-3186
21. Schulze T, Wurst P, Gellermann J et al (2006) in fluence of neoadjuvant radiochemotherapy comb in ed with hyperthermia onthe quality of life in rectum cancer patients. in t J Hyperthermia22:301-318
22. AJCC American Jo in t Committee on Cancer (1997) in : Flem in gDI, Cooper SJ, Henson ED et al (eds) AJCC cancer stag in gmanual, 5th edn. Lipp in cott-Raven, Philadelphia, pp 83-90
23. Urso E, Serpentini S, Pucciarelli S et al (2006) Complications,functional outcome and quality of life after in tensive preoperativechemoradiotherapy for rectal cancer. Eur J Surg Oncol 32:1201-1208
24. Aaronsonn K., Ahmedzai S, Bergman B et al (1993) the Europeanorganization for research and treatment of cancerQLQ-C30: A quality- of -life in strument for use in in ternationalclin ical trials inoncology. J Natl Cancer in st 85:365-376
25. Sprangers MAG, te Velde A, Aaronsonn K. (1999) the Construction and test ing of the EORTC colorectal cancerspecificquality of life questionnaire module (QLQ-CR38) .Europeanorganization for Research and Treatment of CancerStudy Group on Quality of Life. Eur J Cancer 35:238-247
26. Cull A, Sprangers M, Bjordal K, Aaronson N, West K, BottomleyA (2002) EORTC quality of life group translation procedure, 2ndedn. EORTC, Brussels
27. Vaizey CJ, Carapeti E, Cahill JA, Kamm MA (1999) Prospectivecomparisonof faecalin cont in ence graDing systems. Gut 44:77-80
28. Fazio WF, Zutshi M, Remzi FH et al (2007) A randomized trial to compare long-term functional outcome, quality of life, andcomplications of surgical procedures for low rectal cancers. Ann Surg 246:481-490
29. Fayers P, Aaronson N, Bjordal K, Curran D, Groenvold M (1999) EORTC QLQ-C30 scor ing manual, 2nd edn. EORTC Quality of Life Study Group, Brussels
30. Schwarz R, Hinz A (2001) Reference data for the quality of lifequestionnaire EORTC QLQ-C30 in the general German population.Eur J Cancer 37:1345-1351
31. Osoba D, Rodrigues G, Myles J, Zee B, Pater J (1998) in terpret ing the significance of changes in health-related quality of -life scores. J Clinoncol 16:139-144
32. Thiesen F, Kauer WKH, Nekarda H et al (2006) Neoadjuvantradiochemotherapy for patients with locally advanced rectalcancer leads to impairment of the anal sph in cter. J Gastro in test Surg 10:309-314
33. Pollack J, Holm T, Cedermark B, Holmstrom B, Mellgren A (2006) Long-term effect of preoperative radiation therapy onanorectal function. Dis Colon Rectum 49:345-352
34. Temple LK, Bacik J, Savatta SG et al (2005) the development of avalidated in strument to evaluate bowel function after sph in cterpreserv in gsurgery for rectal cancer. Dis Colon Rectum48:1353-1364
35. Pucciarelli S, Del Bianco P, to ppan P et al (2008) Health-related quality of life outcomes in disease-free survivors of mid-low rectalcancer after curative surgery. Ann Surg Oncol 15:1846-1854
36. Arndt V, Merx H, Stegmaier C, Ziegler H, Brenner H (2006) Restrictions in quality of life in colorectal cancer patients overthree years after diagnosis: A population based study. Eur J Cancer42:1848-1857
37. Arndt V, Merx H, Stegmaier C, Ziegler H, Brenner H (2004) Quality of life in patients with colorectal cancer 1 year afterdiagnosis compared with the general population: A populationbasedstudy. J Clinoncol 22:4829-4836
38. Guren MG, Dueland S, Skovlunde et al (2003) Quality of lifedur ing radiotherapy for rectal cancer. Eur J Cancer 39:587-594
39. Apolone G, Filiberti A, Cifani S, Ruggiata R, Mosconi P (1998) Evaluationof the EORTC QLQ-C30 questionnaire: A comparisonwith SF-36 health survey in a cohort of Italian long-survivalcancer patients. Annoncol 9:549-557
40. Coco C, Valentini V, Manno A et al (2007) Functional results afterradiochemotherapy and to tal mesorectal excision for rectal cancer. in t J Colorectal Dis 22:903-910
41. Sprangers MAG, Schwartz CE (1999) the challenge of responseshift for quality- of -life-based clin ical oncology research. Annoncol 10:747-749
42. Hagedoorn M, Sneeuw KCA, Aaronson N (2002) Changes in physical function ing and quality of life in patients with cancer:response shift and relative evaluationof one's condition. J Clinepidemiol 55:176-183