Application of arginine as an efficient eluent in cation exchange chromatographic purification of a PEGylated peptide

Journal of Chromatography A

Volumn 1217, Issue 24, 2010, Pages 3783-3793

  Annathur, Gopinath V ^a   Buckley, John J ^a   Muthurania, Kevin ^a   Ramasubramanyan, Natrajan ^a  

^a PFIZER INC   (United States)

Author keywords

Arginine; Chromatography; Hindered diffusion; PEGylation; Peptide; PYY 3 36

Indexed keywords

CATION EXCHANGE CHROMATOGRAPHY; CATION EXCHANGES; CATIONIC AMINO ACIDS; CHROMATOGRAPHIC PERFORMANCE; CHROMATOGRAPHIC PURIFICATION; CONCENTRATION OF; HIGHER YIELD; HINDERED DIFFUSION; HYDRODYNAMIC VOLUMES; IN-PROCESS; MASS TRANSFER RESISTANCES; MOLECULAR SIZE; PEGYLATION; REACTION MIXTURE;

CHROMATOGRAPHY; ORGANIC ACIDS; PEPTIDES; POSITIVE IONS; PURIFICATION; SODIUM CHLORIDE;

AMINO ACIDS;

AMINO ACID; ARGININE; PEPTIDE YY [3-36]; SODIUM CHLORIDE;

ANALYTIC METHOD; ARTICLE; CONCENTRATION PROCESS; CONTROLLED STUDY; HORMONE DETERMINATION; HORMONE STRUCTURE; HYDRODYNAMICS; INTERMETHOD COMPARISON; ION EXCHANGE CHROMATOGRAPHY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; SCALE UP;

ARGININE; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HISTIDINE; HUMANS; LIGHT; LYSINE; PARTICLE SIZE; PEPTIDE YY; POLYETHYLENE GLYCOLS; SCATTERING, RADIATION; SODIUM CHLORIDE; UREA;

EID: 77953602550     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.04.019     Document Type: Article

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