Effect of antihypertensive therapy with α-methyldopa on uterine artery Doppler in pregnancies with hypertensive disorders

Ultrasound in Obstetrics and Gynecology

Volumn 35, Issue 6, 2010, Pages 688-694

  Khalil, A ^a   Harrington, K ^b   Muttukrishna, S ^a   Jauniaux, E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b HOMERTON UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Alpha methyldopa; Antihypertensive; Preeclampsia; Pregnancy; Uterine artery Doppler

Indexed keywords

ANTIHYPERTENSIVE AGENT; METHYLDOPA;

ADULT; ARTICLE; COLOR ULTRASOUND FLOWMETRY; CROSS-SECTIONAL STUDY; DRUG EFFECT; ECHOGRAPHY; FEMALE; FETUS ECHOGRAPHY; HUMAN; MATERNAL HYPERTENSION; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PLACENTA CIRCULATION; PREGNANCY; PROSPECTIVE STUDY; UTERINE ARTERY;

ADULT; ANTIHYPERTENSIVE AGENTS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPERTENSION, PREGNANCY-INDUCED; METHYLDOPA; PLACENTAL CIRCULATION; PREGNANCY; PROSPECTIVE STUDIES; ULTRASONOGRAPHY, DOPPLER, COLOR; ULTRASONOGRAPHY, PRENATAL; UTERINE ARTERY;

EID: 77953599594     PISSN: 09607692     EISSN: 14690705     Source Type: Journal    
DOI: 10.1002/uog.7611     Document Type: Article

References (41)

1. Lewis G (ed). The Confidential Enquiry into Maternal and Child Health (CEMACH). Saving Mothers' Lives: reviewing maternal deaths to make motherhood safer - 2003-2005. The Seventh Report on Confidential Enquiries into Maternal Deaths in the United Kingdom. CEMACH: London, 2007.
2. Sibai B, Dekker G, Kupferminc M. preeclampsia. Lancet 2005; 365: 785-799.
3. Why Mothers Die. Confidential Enquiry Into Maternal And Child Health. Improving the health of mothers, babies and children. The sixth report of the confidential enquiries into maternal deaths in the United Kingdom. RCOG Press: London, 2004; 79-85.
4. Sibai BM, Caritis S, Hauth J. What we have learned about preeclampsia. Semin Perinatol 2003; 27: 239-246.
5. Irgens HU, Reisaeter L, Irgens LM, Lie RT. Long term mortality of mothers and fathers after preeclampsia: population based cohort study. BMJ 2001; 323: 1213-1217.
6. Bellamy L, Casas JP, Hingorani AD, Williams DJ. preeclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ 2007; 335: 974.
7. Roberts JM, Cooper DW. Pathogenesis and genetics of preeclampsia. Lancet 2001; 357: 53-56.
8. Walker JJ. preeclampsia. Lancet 2000; 356: 1260-1265.
9. von Dadelszen P, Magee LA, Roberts JM. Subclassification of preeclampsia. Hypertens Pregnancy 2003; 22: 143-148.
10. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science 2005; 308: 1592-1594.
11. Robertson WB, Brosens I, Landells WN. Abnormal placentation. Obstet Gynecol Annu 1985; 14: 411-426.
12. Khong TY, De Wolf F, Robertson WB, Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by preeclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol 1986; 93: 1049-1059.
13. Meekins JW, Pijnenborg R, Hanssens M, McFadyen IR, van Asshe A. A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies. Br J Obstet Gynaecol 1994; 101: 669-674.
14. Hung TH, Skepper JN, Burton GJ. In vitro ischemia-reper-fusion injury in term human placenta as a model for oxidative stress in pathological pregnancies. Am J Pathol 2001; 159: 1031-1043.
15. Tamura H, Miwa I, Taniguchi K, Maekawa R, Asada H, Taketani T, Matsuoka A, Yamagata Y, Ishikawa H, Sugino N. Different changes in resistance index between uterine artery and uterine radial artery during early pregnancy. Hum Reprod 2008; 23: 285-289.
16. Tekay A, Martikainen H, Jouppila P. Blood flow changes in uterine and ovarian vasculature, and predictive value of transvaginal pulsed colour Doppler ultrasonography in an in-vitro fertilization programme. Hum Reprod 1995; 10: 688-693.
17. Schulman H, Fleischer A, Farmakides G, Bracero L, Rochelson B, Grunfeld L. Development of uterine artery compliance in pregnancy as detected by Doppler ultrasound. Am J Obstet Gynecol 1986; 155: 1031-1036.
18. Pearce JM, Campbell S, Cohen-Overbeek T, Hackett G, Hernandez J, Royston JP. References ranges and sources of variation for indices of pulsed Doppler flow velocity waveforms from the uteroplacental and fetal circulation. Br J Obstet Gynaecol 1988; 95: 248-256.
19. Bower S, Bewley S, Campbell S. Improved prediction of preeclampsia by two-stage screening of uterine arteries using the early diastolic notch and color Doppler imaging. Obstet Gynecol 1993; 82: 78-83.
20. Ochi H, Matsubara K, Kusanagi Y, Taniguchi H, Ito M. Significance of a diastolic notch in the uterine artery flow velocity waveform induced by uterine embolisation in the pregnant ewe. Br J Obstet Gynaecol 1998; 105: 1118-1121.
21. Wallenburg H. Haemodynamics in hypertensive pregnancy. In Handbook of Hypertension, vol. 21, Rubin P (ed.). Elsevier Science Publishers: Amsterdam, 2000; 181-220.
22. Khedun SM, Moodley J, Naicker T, Maharaj B. Drug management of hypertensive disorders of pregnancy. Pharmacol Ther 1997; 74: 221-258.
23. Günenç O, Ciçek N, Görkemli H, Celik C, Acar A, Akyürek C. The effect of methyldopa treatment on uterine, umbilical and fetal middle cerebral artery blood flows in preeclamptic patients. Arch Gynecol Obstet 2002; 266: 141-144.
24. Montan S, Anandakumar C, Arulkumaran S, Ingemarsson I, Ratnam SS. Effects of methyldopa on uteroplacental and fetal hemodynamics in pregnancy-induced hypertension. Am J Obstet Gynecol 1993; 168: 152-156.
25. Montan S, Anandakumar C, Arulkumaran S, Ingemarsson I, Ratnam S. Randomised controlled trial of methyldopa and isradipine in preeclampsia - effects on uteroplacental and fetal hemodynamics. J Perinat Med 1996; 24: 177-184.
26. Rey E. Effects of methyldopa on umbilical and placental artery blood flow velocity waveforms. Obstet Gynecol 1992; 80: 783-787.
27. Roberts JM, Pearson G, Cutler J, Lindheimer M; NHLBI Working Group on Research on Hypertension During Pregnancy. Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy. Hypertension 2003; 41: 437-445.
28. Fleischer A, Schulman H, Farmakides G, Bracero L, Grunfeld L, Rochelson B, Koenigsberg M. Uterine artery Doppler velocimetry in pregnant women with hypertension. Am J Obstet Gynecol 1986; 154: 806-813.
29. McCowan LM, Ritchie K, Mo LY, Bascom PA, Sherret H. Uterine artery flow velocity waveforms in normal and growth-retarded pregnancies. Am J Obstet Gynecol 1988; 158: 499-504.
30. Boito SM, Struijk PC, Pop GA, Visser W, Steegers EA, Wladimiroff JW. The impact of maternal plasma volume expansion and antihypertensive treatment with intravenous dihydralazine on fetal and maternal hemodynamics during preeclampsia: a clinical, echo-Doppler and viscometric study. Ultrasound Obstet Gynecol 2004; 23: 327-332.
31. Joern H, Rath W. Comparison of Doppler sonographic examinations of the umbilical and uterine arteries in high-risk pregnancies. Fetal Diagn Ther 1998; 13: 150-153.
32. van Asselt K, Gudmundsson S, Lindqvist P, Marsal K. Uterine and umbilical artery velocimetry in preeclampsia. Acta Obstet Gynecol Scand 1998; 77: 614-619.
33. Hauth JC, Ewell MG, Levine RJ, Esterlitz JR, Sibai B, Curet LB, Catalano M, Morris CD. Pregnancy outcomes in healthy nulli-paras who developed hypertension. Calcium for Preeclampsia Prevention Study Group. Obstet Gynecol 2000; 95: 24-28.
34. Ferrazzani S, Caruso A, De Carolis S, Martino IV, Mancuso S. Proteinuria and outcome of 444 pregnancies complicated by hypertension. Am J Obstet Gynecol 1990; 162: 366-371.
35. Buchbinder A, Sibai BM, Caritis S, MacPherson C, Hauth J, Lindheimer MD, Klebanoff M, Vandorsten P, Landon M, Paul R, Miodovnik M, Meis P, Thurnau G; National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia. Am J Obstet Gynecol 2002; 186: 66-71.
36. Frusca T, Soregaroli M, Platto C, Enterri L, Lojacono A, Valcamonico A. Uterine artery velocimetry in patients with gestational hypertension. Obstet Gynecol 2003; 102: 136-140.
37. Andersch B, Svensson A, Hansson L. Characteristics of hypertension in pregnancy. A retrospective study of 261 consecutive cases. Acta Obstet Gynecol Scand Suppl 1984; 118: 33-38.
38. Abalos E, Duley L, Steyn DW, Henderson-Smart DJ. Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev 2007; CD002252.
39. Khalil A, Muttukrishna S, Harrington K, Jauniaux E. Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders. PLoS One 2008; 3: e2766.
40. Khalil A, Jauniaux E, Harrington K, Muttukrishna S. Placental production and maternal serum and urine levels of inhibin A and activin A are modified by antihypertensive therapy in hypertensive disorders of pregnancy. Clin Endocrinol 2009; 70: 924-931.
41. Khalil A, Jauniaux E, Harrington K. Antihypertensive therapy and central hemodynamics in women with hypertensive disorders in pregnancy. Obstet Gynecol 2009; 113: 646-654.