Electroosmotic transport of mannitol across human nail during constant current iontophoresis

Journal of Pharmacy and Pharmacology

Volumn 62, Issue 6, 2010, Pages 721-729

  Dutet, Julie ^a   Delgado Charro, M Begoña ^a  

^a University of Bath   (United Kingdom)

Author keywords

Electroosmosis; Iontophoresis; Mannitol; Nail; Permselectivity

Indexed keywords

CARBON 14; GLUCOSE; MANNITOL;

ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DRUG ACCUMULATION; DRUG DIFFUSION; ELECTROOSMOSIS; HUMAN; HUMAN TISSUE; IONTOPHORESIS; NAIL; PASSIVE TRANSPORT; PH; STATISTICS; ADULT; FEMALE; IN VITRO STUDY; METABOLISM; TOPICAL DRUG ADMINISTRATION; TRANSPORT AT THE CELLULAR LEVEL; YOUNG ADULT;

ADMINISTRATION, TOPICAL; ADULT; BIOLOGICAL TRANSPORT; ELECTROOSMOSIS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; IN VITRO TECHNIQUES; IONTOPHORESIS; MANNITOL; NAILS; YOUNG ADULT;

EID: 77953594289     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.62.06.0008     Document Type: Article

References (27)

1. Schlefman BS. Onychomycosis: A compendium of facts and a clinical experience. J Foot Ankle Surg 2009 38: 290 302.
2. Debruyne D, Coquerel A. Pharmacokinetics of antifungal agents in onychomycosis. Clin Pharmacokinet 2001 40: 441 472.
3. Crawford F, Hollis S. Topical treatments for fungal infections of the skin and nails of the foot (Review). The Cochrane Library 2007 3: 1 122.
4. Murdan S. Drug delivery to the nail following topical application. Int J Pharm 2002 236: 1 26.
5. Elkeeb R et al. Transungual drug delivery: current status. Int J Pharm 2010 384: 1 8.
6. Hao SJ, Li SK. Transungual iontophoretic transport of polar neutral and positively charged model permeants: effects of electrophoresis and electroosmosis. J Pharm Sci 2008 97: 893 905.
7. Hao J et al. Chemical method to enhance transungual transport and iontophoresis efficiency. Int J Pharm 2008 357: 61 69.
8. Hao SJ, Li SK. Mechanistic study of electroosmostic transport across hydrated nail plates: effects of pH and ionic strength. J Pharm Sci 2008 97: 5186 5197.
9. Murthy SN et al. Iontophoretic permselective property of human nail. J Derm Sci 2007 46: 150 152.
10. Murthy SN et al. Iontophoretic drug delivery across human nail. J Pharm Sci 2007 96: 305 311.
11. Delgado-Charro MB, Guy RH. Transdermal iontophoresis for drug delivery and non-invasive monitoring. STP Pharma Sciences 2001 11: 403 414.
12. Pikal MJ. The role of electroosmotic flow in transdermal iontophoresis. Adv Drug Deliv Rev 1992 9: 201 237.
13. Marro D et al. Contributions of electromigration and electroosmosis in iontophoretic drug delivery. Pharm Res 2001 18: 1701 1708.
14. Kim A et al. Convective solvent flow across the skin during iontophoresis. Pharm Res 1993 10: 1315 1320.
15. Green PG et al. Iontophoretic delivery of amino acids and amino acid derivatives across the skin in vitro. Pharm Res 1991 8: 1113 1120.
16. Zar JH. Biostatistical analysis, 2nd edn.
17. Marro D et al. Characterization of the iontophoretic permselectivity properties of human and pig skin. J Control Release 2001 70: 213 217.
18. López-Castellanos A et al. Effect of area on the iontophoretic transport of phenylalanine and propranolol across the skin. In: Proceedings of the 26th International Symposium on Controlled Release of Bioactive Material, 1999: 405 406.
19. Dutet J, Delgado-Charro MB. In vivo transungual iontophoresis: effect of DC current application on ionic transport and on transonychial water loss. J Control Release 2009 140: 117 125.
20. Dawder RPR et al. Science of the nail apparatus. In Baran R et al eds. Baran and Dawder's Diseases of the Nail and their Management.
21. Gunt H, Kasting GB. Hydration effect on human nail permeability. J Cosmet Sci 2006 57: 183 184.
22. Khengar RH et al. Nail swelling as a pre-formulation screen for the selection and optimisation of ungual penetration enhancers. Pharm Res 2007 24: 2207 2212.
23. Hao J et al. Time-dependent electrical properties of human nail upon hydration in vivo. J Pharm Sci 2010 99: 107 118.
24. Wessel S et al. Hydration of human nails investigated by NIR-FR-Raman spectroscopy. Biochim Biophys Acta 1999 1433: 210 216.
25. Hui X et al. Enhanced human nail drug delivery: nail inner drug content assayed by new unique method. J Pharm Sci 2002 91: 189 195.
26. Leyden J. Pharmacokinetics and pharmacology of terbinafine and itraconazole. J Am Acad Dermatol 1998 38: S42 S47.
27. Dutet J et al. Transungual iontophoresis: in vitro and in vivo studies. In: Proceedings of the 36th Annual Meeting and Exposition of the Controlled Release Society, 2009